Journal of International Oncology››2012,Vol. 39››Issue (6): 439-442.

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DNA methylation in Barrett esophagus and esophageal adenocarcinoma

LI Bo, LING Zhi-qiang, MAO Wei-min

  1. Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:MAO Wei-min, E-mail: maowm1218@163.com E-mail:maowm1218@163.com

Abstract:In recent years, a large number of researches show that the tumor related gene promoter hypermethylation is an important reason of esophageal adenocarcinoma and closely associated with the differentiation, invasion, metastasis, staging and prognosis of tumors. It might be used as a new target for the clinical detection and therapy of esophageal adenocarcinoma.

Key words:DNA methylation,Barrett′s esophagus,Esophageal neoplasms,Adenocarcinoma