Journal of International Oncology››2012,Vol. 39››Issue (6): 462-464.

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Effect of cyclooxygenase-2 inhibitor in anti-leukemia

XIE Xia*, HAO Hong-ling

  1. Department of Clinical Laboratory, Hebei People's Hospital, Shijiazhuang 050051, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:HAO Hong-ling, E-mail: h0707@163.com E-mail:h0707@163.com

Abstract:Cyclooxygenase-2 (COX-2) plays an important role in the development of leukemia. COX-2 inhibitor plays a certain antileukemia role in the process. Many studies show that COX-2 inhibitor plays antileukemia role by inhibiting the proliferation of leukemia cell, promoting apoptosis, affecting cell cycle, inhibiting cell metastasis and reversing cell drug resistance and so on. Therefore, the researches about the antileukemia mechanisms of COX-2 inhibitor will provide a new target in clinical prevention and treatment of leukemia.

Key words:Leukemia,Cell cycle,Apoptosis