Journal of International Oncology››2013,Vol. 40››Issue (3): 170-173.

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Oncogenic mechanism and biological effect of Evi-1 gene

DING Xiang-Ping, ZHANG Jin-Hua

  1. Department ofGastroenterology, Second People’s Hospital of GansuProvince , Lanzhou 730030, China
  • Online:2013-03-08Published:2013-02-25
  • Contact:ZHANG Jin-hua, E-mail: zjh51272@163.com E-mail:zjh51272@163.com

Abstract:Ecotropic viral integration site-1 (Evi-1) gene is first identified as a binding site for retrovirus in murine myeloid leukemia. The humanhomologue withthe murine in leukemia oncogene Evi-1 is about 91% of nuclear sequence and 94% of amino acid. Evi-1 gene is high expressed in myeloid malignancies and other tumors. The main tumorigenic mechanisms of Evi-1 gene include inhibiting TGF-β signal path by depressing Smad3, adjusting cell cycle, promoting angiogenesis, inhibiting JNK, activating AP-1, and so on.

Key words:Evi-1 gene,Smad3 protein,Leukemia,TGF-&beta,signal transduction,Neoplasms