动脉瘤性蛛网膜下腔出血患者脑脊液MIF水平与迟发性脑缺血的关系

betway必威登陆网址（betway.com ）学报››2021,Vol. 42››Issue (1): 46-48.DOI:10.3969/j.issn.1004-7115.2021.01.011

动脉瘤性蛛网膜下腔出血患者脑脊液MIF水平与迟发性脑缺血的关系

王伟

betway必威登陆网址附属泰安第一人民医院,山东泰安 271000

收稿日期:2020-09-25发布日期:2021-09-01
作者简介:王伟,主治医师,主要从事神经内科工作,E-amil:378604534@qq.com。

Changes of cerebrospinal fluid MIF level in patients with aneurismal subarachnoid hemorrhage and its relationship with delayed cerebral ischemia

WANG Wei

The First People's Hospital of Taian Affiliated to Shandong First Medical University, Taian 271000,China

Received:2020-09-25Published:2021-09-01

摘要/Abstract

摘要：目的探讨动脉瘤性蛛网膜下腔出血(aneurysmal subarachnoid hemorrhage, aSAH)患者脑脊液巨噬细胞游走抑制因子(macrophage migration inhibitory factor, MIF)水平变化与迟发性脑缺血的关系。方法纳入71名aSAH患者,分析临床一般资料。蛛网膜下腔出血后第0~3天、4~6天和7~9天从脑室外引流收集脑脊液样品,使用ELISA试剂盒测定MIF浓度。结果 27名aSAH患者并发迟发性脑缺血,其Hunt-Hess分级、WFNS分级及改良Fisher分级明显增加,脑脊液中MIF浓度显著增加。出血后3天内的MIF浓度与DCI的等级显著相关。结论 aSAH患者的脑脊液MIF水平与DCI相关。

关键词:动脉瘤蛛网膜下腔出血,巨噬细胞游走抑制因子,迟发性脑缺血

Abstract:Objective: To investigate the relationship between cerebrospinal fluid(CSF) macrophage migration inhibitory factor (MIF) levels and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: Seventy-one aSAH patients were included and the general clinical data. CSF samples collected from the external ventricular drainage at day 0-3, 4-6 and 7-9 after aSAH were analyzed. The MIF concentration was measured with ELISA kit. Results: Twenty-seven SAH patients developed DCI. The Hunt-Hess grade, WFNS grade, modified Fisher grade, and the MIF concentration in the cerebrospinal fluid increased significantly in aSAH patients with DCI. The MIF concentration within 3 days following hemorrhage significantly correlated with the grade of DCI. Conclusion: CSF level of MIF is correlated with DCI in aSAH patients.

Key words:aneurysmal subarachnoid hemorrhage,macrophage migration inhibitory factor,delayed cerebral ischemia

中图分类号:

R651.1

王伟. 动脉瘤性蛛网膜下腔出血患者脑脊液MIF水平与迟发性脑缺血的关系[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(1): 46-48.

WANG Wei. Changes of cerebrospinal fluid MIF level in patients with aneurismal subarachnoid hemorrhage and its relationship with delayed cerebral ischemia[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(1): 46-48.

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