免疫时代肿瘤放疗值得关注的研究方向

betway必威登陆网址（betway.com ）学报››2021,Vol. 42››Issue (5): 327-332.DOI:10.3969/j.issn.2097-0005.2021.05.002

免疫时代肿瘤放疗值得关注的研究方向

刘成新, 李宝生

betway必威登陆网址附属肿瘤医院放疗科,山东济南 250117

收稿日期:2021-04-09出版日期:2021-05-25发布日期:2021-08-31
通讯作者:李宝生,E-mail:bsli@sdfmu.edu.cn。
作者简介:刘成新,主治医师,博士,主要从事肿瘤放射治疗学工作。李宝生,betway必威登陆网址附属肿瘤医院副院长,研究员,医学博士,博士生导师,享受国务院特殊津贴专家,山东省肿瘤医院知名专家。中华医学会放射肿瘤治疗学分会委员会候任主任委员,中国医师协会放射肿瘤治疗医师分会会长, 中国医师协会毕业后医学教育放射肿瘤科专业委员会主任委员,中国抗癌协会肿瘤放疗分会副主委,中国临床肿瘤学会食管癌专家委员会委员,山东省医学会肿瘤学分会委员会候任主任委员, 山东省医学会肺癌多学科联合委员会主席, 山东省医师协会肿瘤放疗医师分会委员会主任委员, 中国北方肿瘤放射治疗协作组委员会主席。擅长胸部肿瘤的放射治疗及综合治疗,以第一或通讯作者发表SCI论文百余篇,以第一完成人获国家科技进步二等奖1项,以第二和第三完成人获国家科技进步二等奖各1项,以第一完成人获山东省科技进步一等奖2项,二等奖2项,三等奖1项,以第一完成人获中华医学科技奖二等奖1项,三等奖1项。主持国家级课题6项,省部级课题12项,培养博士研究生29名,博士后8名。
基金资助:
国家自然科学基金(81874224);山东省自然科学基金(ZR2013HM080)。

Research directions worth paying attention to in tumor radiotherapy in the immune era

Liu Chengxin, Li Baosheng

Department of Radiation Oncology, Affiliated Tumor Hospital of Shandong First Medical University, Jinan 250117,China

Received:2021-04-09Online:2021-05-25Published:2021-08-31

摘要/Abstract

摘要：免疫治疗在肿瘤治疗中的地位日益重要,其中免疫检查点抑制剂表现尤为突出,然而其单独应用的有效率较低,而与肿瘤传统治疗的联合常常能产生协同抗肿瘤效应,尤其与放射治疗的联合非常值得期待。放疗可通过多种方式调控免疫反应进而直接或间接作用于肿瘤细胞,如诱导免疫原性细胞死亡或改变肿瘤微环境中的免疫细胞浸润等。而免疫治疗则可通过调节肿瘤微环境中浸润的免疫细胞、血管正常化等方面影响放疗的效果。本文重点阐述免疫治疗和放疗之间的相互作用,并详细阐述了不同放疗剂量分割、时机对免疫治疗的影响,展望放疗在免疫时代需要解决的问题和未来发展方向。

关键词:放射治疗,免疫治疗,肿瘤微环境

Abstract:Immunotherapy plays an increasingly important role in cancer treatment, especially immune checkpoint inhibitor therapy. However, due to low immunotherapy efficiency, a synergistic anti-tumor response may be produced through combined application with traditional tumor treatment methods. Among them immune combined radiotherapy is highly anticipated. Radiotherapy can directly or indirectly act on tumor cells by regulating the immune response in a variety of ways, such as inducing immunogenic cell death or changing the immune cell infiltration in the tumor microenvironment. Immunotherapy can also affect the effect of radiotherapy by regulating the infiltrating immune cells in the tumor microenvironment and the normalization of blood vessels. This article focuses on the interaction and theoretical basis between immunotherapy and radiotherapy, then analyzes in detail the effects of different doses and timely radiotherapy on immune response, and finally summarizes the problems and future development directions of radiotherapy under the influence of immunotherapy.

Key words:radiotherapy,immunotherapy,tumor microenvironment

中图分类号:

R730.55

刘成新, 李宝生. 免疫时代肿瘤放疗值得关注的研究方向[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(5): 327-332.

Liu Chengxin, Li Baosheng. Research directions worth paying attention to in tumor radiotherapy in the immune era[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(5): 327-332.

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