肠道3型固有淋巴细胞研究进展

betway必威登陆网址（betway.com ）学报››2021,Vol. 42››Issue (5): 347-357.DOI:10.3969/j.issn.2097-0005.2021.05.005

王新, 陈正涛, 唐华

betway必威登陆网址 (betway.com )科创中心,山东泰安 250117

收稿日期:2021-01-22出版日期:2021-05-25发布日期:2021-08-31
通讯作者:唐华,E-mail:tanghuazhang218@163.com。
作者简介:王新,硕士研究生,研究方向:细胞免疫,E-mail:13038092719@163.com;陈正涛,讲师,研究方向:黏膜免疫,E-mail:cztd_666@163.com。王新和陈正涛为共同第一作者。唐华,二级教授, 浙江大学肿瘤学博士,美国EMORY大学博士后,中国免疫学会会员,山东免疫学会第六届常务理事。山东省引进海外高层次创新人才、泰山学者海外特聘专家、山东省有突出贡献的中青年专家、山东省留学人员回国创业奖获得者。多年来从事树突状细胞的研究,特别关注该细胞对获得性免疫的调控在人类重大免疫相关性疾病中的作用。2010年底回国到betway必威登陆网址泰安校区(原泰山医学院)组建研究团队,2021年被聘为betway必威登陆网址医学科技创新中心PI。指导团队累计获得24项国家级课题,其中包括其本人主持的“973”课题1项、国家自然科学基金重大研究计划1项和国家自然科学基金面上项目3项。获国家发明专利2项,以第一作者或通讯作者在Nature Immunology、Nature Communications、Blood、Cancer Letters、eBiomedicine等杂志上发表SCI论文多篇。
基金资助:
国家重大betway必威亚洲计划(2015CB943203);国家自然科学基金(81971552,81272315);betway必威登陆网址学术提升计划(2019QL007)。

Research progress of intestinal type 3 innate lymphoid cells

Wang Xin, Chen Zhengtao, Tang Hua

Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China

Received:2021-01-22Online:2021-05-25Published:2021-08-31

摘要/Abstract

摘要：固有淋巴细胞(innate lymphoid cells,ILCs)是十多年前才发现的免疫系统“新兵”,是一类新型固有免疫细胞,是免疫系统的重要组成部分。它们在调节机体组织区域免疫反应和稳态维持方面发挥重要作用。根据ILCs表达的转录因子和分泌的细胞因子的不同可以将其分为三个不同类群:ILC1s、ILC2s以及ILC3s。其中ILC3s主要存在于肠道,并通过参与促进淋巴器官形成、维持上皮屏障完整、调节肠道炎症、促进抗菌反应等方面来维持肠道黏膜区域免疫的稳态。本文将对ILC3s的发育、特性以及在肠道区域免疫系统中的病理生理功能做一综述,概括当前ILC3s的主要研究进展。

关键词:3型固有淋巴细胞,发育,肠道免疫稳态

Abstract:Innate lymphoid cells (ILCs) are a new class of innate immune cells that are an important component of the immune system and were discovered more than a decade ago. They play an important role in regulating the immune response and homeostasis. According to the different transcription factors expressed and cytokines secreted by ILCs, they can be divided into three distinct groups: ILC1s, ILC2s and ILC3s. Among them, ILC3s mainly exist in the intestinal tract, and maintain the immune homeostasis of the intestinal mucosa by participating in promoting the formation of lymphatic organs, maintaining the integrity of the epithelial barrier, regulating intestinal inflammation, and promoting antibacterial response. The author of this article reviews the development, characteristics and pathophysiological functions of ILC3s in the immune system of the intestine and summarizes the main research progress of ILC3s.

Key words:type 3 innate lymphoid cells,development,intestinal immune homeostasis

中图分类号:

R392

王新, 陈正涛, 唐华. 肠道3型固有淋巴细胞研究进展[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(5): 347-357.

Wang Xin, Chen Zhengtao, Tang Hua. Research progress of intestinal type 3 innate lymphoid cells[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(5): 347-357.

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