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Research progress of Wnt/β-catenin signaling pathway in tumor immunity Huanhuan ZHANG, Lei ZHANG, Jie CUI, Yinpan LIANG, Shuying YI Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 716-720. DOI:10.3969/j.issn.2097-0005.2023.09.016 Abstract（ 253） HTML（ 21） PDF（pc）（421KB）（ 67） Knowledge map Save The Wnt/β-catenin signaling pathway is a highly conserved pathway that regulates cell proliferation， differentiation， apoptosis， stem cell self-renewal， tissue homeostasis， and wound healing. Dysregulation of the Wnt pathway is involved in almost all stages of tumorigenesis in various cancers.Abnormal activation of Wnt/β-catenin signal transduction contributes to immune rejection and inhibits T cell-mediated antitumor immune responses through direct or indirect effects on immune cells. In this review， we summarize the processes by which Wnt/β-catenin signaling influences tumor progression and immune surveillance， as well as strategies for targeting this signaling pathway at different levels for cancer therapy. Reference|Related Articles|Metrics|Comments（0）

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Research progress of sepsis associated encephalopathy Wenyu LI, Hongna YANG, Wei FANG, Xuan SONG, Chunting WANG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 707-711. DOI:10.3969/j.issn.2097-0005.2023.09.014 Abstract（ 245） PDF（pc）（464KB）（ 151） Knowledge map Save Sepsis associated encephalopathy （SAE） is a nervous system complication caused by systemic inflammatory reaction of sepsis， which is an important reason for the high mortality and poor long-term recovery of patients with sepsis. Clinically， it is divided into acute phase and chronic phase. The main clinical manifestations in the acute phase are changes in the level of consciousness， including attention deficit， delirium， lethargy and coma. In the chronic phase， cognitive dysfunction and even dementia occur. The clinical diagnosis of SAE lacks a unified clinical standard. Researchers should strive to better understand the pathophysiological mechanism of sepsis and explore possible effective intervention and treatment measures. This article reviews the pathophysiological mechanism， diagnosis， treatment and prevention of SAE. Reference|Related Articles|Metrics|Comments（0）

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Effects of recombinant human growth hormone on palmitic acid induced lipid deposition in HepG2 cells Fang ZHANG, Liyuan RAN, Jinjin ZHANG, Yingjie WU Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 641-646. DOI:10.3969/j.issn.2097-0005.2023.09.001 Abstract（ 197） HTML（ 744） PDF（pc）（4018KB）（ 150） Knowledge map Save ObjectiveTo explore the effect of recombinant human growth hormone （rhGH） on the lipid metabolism of fatty liver cell model induced in vitro， and to provide theoretical support for further expanding the application of rhGH in clinical practice.MethodsPalmitic acid （PA） was combined to induce lipid accumulation in HepG2 cells， and a fatty liver cell model was constructed. The cell model was treated with different concentrations of rhGH， and CCK8 assay was used to detect the effects of different concentrations of PA and rhGH on the survival of HepG2 cells. The lipid accumulation level in HepG2 cells was evaluated by oil red O staining， the expression levels of genes and proteins related to lipid metabolism in HepG2 cell lines were evaluated by RT-qPCR and Western blot， and the mechanism of action of rhGH was preliminarily explored.ResultsIn this study， 0.2 mmol/L PA successfully induced a fatty liver cell model， which showed significant accumulation of lipid droplets in the cytoplasm. After being stimulated by rhGH， the accumulation of intracellular lipid droplets decreased with the increase of rhGH concentration， and the rhGH concentration of 40 ng/mL achieved a significant lipid-lowering effect. The results of RT-qPCR and Western blot showed that the expression of genes and proteins related to lipid synthesis in cells were significantly down-regulated after rhGH treatment， while the expressions of genes and proteins related to lipolysis had no significant changes.ConclusionrhGH can alleviate the lipid deposition in HepG2 cells induced by PA by inhibiting the de novo fatty acid synthesis pathway. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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A new way of lung cancer treatment： immunogenic cell death Zengming WANG, Shuangqing CHEN, Dahu REN, Bin ZHAO, Hongzhen ZHAO, Guochen DUAN Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences 2024, 45 (5): 310-314. DOI:10.3969/j.issn.2097-0005.2024.05.011 Abstract（ 189） HTML（ 11） PDF（pc）（553KB）（ 49） Knowledge map Save Lung cancer is one of the malignant tumors with the fastest increase in morbidity and mortality and the greatest threat to human life worldwide. Patients diagnosed with lung cancer usually receive a variety of treatments， including surgery， chemotherapy and/or radiation therapy， immunotherapy， and targeted therapy； However， the five-year survival rate for lung cancer remains low， especially when the cancer has reached an advanced stage or distant metastasis has occurred. Therefore， more effective and novel technologies must be developed to solve this problem. Inducer application of immunogenic cell death （ICD） has been proved to enhance immunity in patients receiving various types of therapy. The term ICD refers to a type of cell death that triggers an immune response to dead cell antigens， especially antigens derived from cancer cells. It was originally proposed about the effects of anti-cancer chemotherapy with traditional cytotoxic drugs. The purpose of this study is to review and discuss the role and mechanism of ICD as a promising combination immunotherapy for lung cancer. Reference|Related Articles|Metrics|Comments（0）

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Application of biologic regimens combination in antiphospholipid syndrome Xiaoyu ZHANG, Qiang SHU Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 881-889. DOI:10.3969/j.issn.2097-0005.2023.12.001 Abstract（ 163） HTML（ 7） PDF（pc）（590KB）（ 114） Knowledge map Save The current consensus guidelines for the prevention and treatment of APS are mainly based on the use of low-dose aspirin， vitamin K antagonists and heparin， and the management of the clinical manifestations of NC-APS. The concept of NC-APS came out in recent years and not much high-level consensus guidelines have been developed. If the patients with antiphospholipid antibodies（aPL） positive combined with other diseases， pregnancy， surgery or infection， they could develop to recurrent and dangerous catastrophic APS （CAPS）. This article focuses on the mechanisms of aPL production，clinical manifestations of APS，treatment of related symptoms，especially rituximab，belimumab and telitacicept. New strategies of biologic regimens combination for refractory APS is demonstrates at last. Reference|Related Articles|Metrics|Comments（0）

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Clinical pathological and prognostic significance of PD-L1 expression in lung adenocarcinoma in bioinformatics Nana DU, Lu ZHANG, Jingting MIN, Ran AN, Zhenghong LI Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences 2024, 45 (4): 193-197. DOI:10.3969/j.issn.2097-0005.2024.04.001 Abstract（ 154） HTML（ 11） PDF（pc）（1960KB）（ 26） Knowledge map Save ObjectiveTo evaluate the clinical pathological and prognostic significance of PD-L1 expression in lung adenocarcinoma with bioinformatics， and to validate its expression and clinical pathology with immunohistochemistry.MethodsUsing the GEPIA database to analyze the quantitative expression of PD-L1 mRNA in the database， and validate it with immunohistochemical methods； Using Te Kaplan Meier Plotter to evaluate the impact of PD-L1 expression on the prognostic value of lung adenocarcinoma； Analyzing immune cell infiltration in lung adenocarcinoma with Timer2.0； Differential analysis of the expression of different subtypes of PD-L1 in lung adenocarcinoma was performed by the TCGA module of the UALCAN database.ResultsBioinformatics showed that the expression of PD-L1 in cancer tissue was significantly lower than that in normal tissue. Immunohistochemical results showed that PD-L1 was highly expressed in lung adenocarcinoma tissue， but low or no expression was observed in adjacent tissues. The expression of PD-L1 was not significantly different by age， sex， clinical stage and lymph node metastasis， but its expression was significantly correlated with the overall survival OS and first progressive survival FP of patients.ConclusionPD-L1 expression affects the survival prognosis of lung adenocarcinoma patients. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Recent advances in the treatment of Helicobacter pylori infection Ruirui WANG, yan LU Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 687-690. DOI:10.3969/j.issn.2097-0005.2023.09.010 Abstract（ 148） HTML（ 6） PDF（pc）（486KB）（ 54） Knowledge map Save Helicobacter pylori （HP） is a kind of gram-negative bacteria that can cause gastritis， peptic ulcer， gastric cancer and lymphatic tissue lymphoma associated with gastric mucosa and other diseases. Its presense increases the incidence of gastric diseases， therefore， the treatment of HP infection has become a research hotspot of many scholars. This article summarizes the treatment progress of HP based on the latest literature. The results show that potassiumcompetitive acid blocker， probiotics， vitamin D， traditional Chinese medicine and myricetin have significant advantages in anti-HP or synergistic anti-HP Reference|Related Articles|Metrics|Comments（0）

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Comparative analysis of the predictive value of quick Pitt bacteremia score and early clinical failure criteria in secondary bloodstream infection caused by urinary tract infection Changxiu LI, Jing WANG, Heqin DANG, Jin LI, Beibei LIU, Dapeng HOU Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 652-658. DOI:10.3969/j.issn.2097-0005.2023.09.003 Abstract（ 144） HTML（ 5） PDF（pc）（840KB）（ 105） Knowledge map Save ObjectiveTo compare the predictive value of qpitt score and ECFC in the prognosis and death of patients with secondary bloodstream infection caused by urinary tract infection.MethodsThe medical record data of patients aged ≥ 18 years with secondary bloodstream infection caused by urinary tract infection treated in our hospital from January 2018 to December 2020 were collected retrospectively. ROC curve was used to evaluate the predictive efficacy of qPitt score and ECFC for poor prognosis and death.ResultsA total of 266 patients， 116 males and 150 females， aged from 27 to 91 years， with an average age of （63.92 ± 14.52） years， were included. The pathogens of blood culture accounted for 77.44% of Gram-negative bacteria， 19.55% of Gram-positive bacteria and 3.01% of fungi. ECFC had good predictive value for death and poor prognosis （the areas under ROC curve were 0.964 and 0.772， respectively，P< 0.001）. The value of qpitt score in predicting death and poor prognosis was ordinary （the areas under ROC curve were 0.890 and 0.648， respectively，P< 0.001）. The results of consistency test showed that ECFC ≥ 2 had good predictive value for poor prognosis and death （Kappa values were 0.503 and 0.580， respectively）. For patients with qpitt ≥ 2 and ECFC ≥ 2， the mortality of carbapenem antibiotics used at 72-96 hours after admission was significantly reduced （χ2= 6.769，P= 0.014）.ConclusionFor patients with secondary bloodstream infection caused by urinary tract infection， ECFC is better than qPitt score in predicting death and adverse prognosis. ECFC ≥ 2 as a critical value has some guiding significance in predicting death. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Efficacy and safety of TCH neoadjuvant chemotherapy in Chinese patients with HER2 positive breast cancer： a Meta-analysis Yihao ZHAO, Dongbin ZHANG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 659-664. DOI:10.3969/j.issn.2097-0005.2023.09.004 Abstract（ 133） HTML（ 8） PDF（pc）（2990KB）（ 32） Knowledge map Save ObjectiveTo systematically evaluate the efficacy and safety of docetaxel combined with carboplatin and trastuzumab （TCH） neoadjuvant chemotherapy in Chinese patients with HER2 positive breast cancer.MethodsThis study was done througth the registeration of INPLASY website （DOI：10.37766/inplasy2022.10.0003）. PubMed， Embase， Cochrane Library， Wanfang， CNKI and other databases were searched. Randomized controlled trials （RCT） of TCH neoadjuvant chemotherapy in Chinese patients with HER2 positive breast cancer were included， the retrieval period was from the establishment of the database to September 2022， and RevMan5.3 was used for statistical analysis.ResultsNine articles were collected， including 731 patients. The total effective rate of trastuzumab combined with neoadjuvant chemotherapy in Chinese patients with HER2 positive breast cancer was significantly better than that of docetaxel combined with carboplatin （TC） alone （OR= 3.07， 95%CI： 2.11 ? 4.46，P< 0.001）， and subgroup analysis showed that there was no difference in the improvement of total effective rate between northern and southern regions in China. Consequences also showed that the negative rate of HER2 and pathological effective rate in the observation groups were better than those in the control groups （OR= 2.73， 95%CI： 1.48 ? 5.03，P= 0.001） and （OR= 2.68， 95%CI： 1.59 ? 4.52，P <0.001）.ConclusionCompared with neoadjuvant chemotherapy alone， TCH chemotherapy can significantly improve the efficacy of HER2 positive breast cancer patients in China without increasing the incidence of adverse events. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Relationship between physiologic capacity and surgical stress score on perioperative complications of radical hepatectomy in patients with primary hepatocellular carcinoma Lijun TIAN, Yujie SANG, Xueyan LI, Wanhui XU, Jiaqi JIANG, Chengyong QIN, Jianni QI Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences 2024, 45 (6): 321-325. DOI:10.3969/j.issn.2097-0005.2024.06.001 Abstract（ 128） HTML（ 77） PDF（pc）（477KB）（ 80） Knowledge map Save ObjectiveTo study the relationship between physiologic ability and surgical stress score （E-PASS） and perioperative complications of radical hepatectomy in patients with primary liver cancer.Methods124 primary hepatocellular carcinoma patients admitted to our hospital from March 2022 to May 2023 were retrospectively selected as the study subjects， all of whom underwent radical hepatectomy in our hospital. The perioperative complications of these patients were statistically analyzed， and then they were divided into two groups based on the presence or absence of complications， namely the occurrence group （n= 29） and the non-occurrence group （n= 95）. The clinical data and disease-related characteristics of the two groups of patients were compared and E-PASS evaluation was conducted. The multifactorial Logistic regression equation was taken to analyze the relationship between perioperative complications of radical hepatectomy and various indictors， and then ROC curve graphs were drawn to predict the value of E-PASS in evaluating perioperative complications of radical hepatectomy in patients with primary liver cancer.ResultsA total of 124 patients were included in this paper who underwent radical hepatectomy， and 29 patients （23.39%） had perioperative complications， including 2 cases of liver failure （1.61%）， 6 cases of pleural effusion （4.84%）， 4 cases of abdominal abscess （3.23%）， 8 cases of postoperative hemorrhage （6.45%）， and 9 cases of abdominal cavity infection （7.26%）. In addition， patients with no complications were 95 cases （76.61%）. The difference between the occurrence group and the non-occurrence group was significant in terms of age， intraoperative bleeding， preoperative total bilirubin， and preoperative albumin （P< 0.05）. The preoperative risk score （PRS）， surgical stress score （SSS）， and composite risk score （CRS） scores were all higher in the occurrence group than those in the non-occurrence group （P< 0.05）. After multifactorial logistic regression analysis， it was found that PRS， SSS， and CRS would all have a significant positive influence relationship on perioperative complications of radical hepatectomy in patients with primary hepatocellular carcinoma （P< 0.05）. Meanwhile， by drawing ROC curves， it was found that E-PASS has certain value in predicting perioperative complications of radical liver resection with AUCs of 0.617， 0.614， and 0.601 respectively.ConclusionThe perioperative complications of primary hepatocellular carcinoma patients after radical hepatectomy are high， which need to be paid attention to. And the value of predicting perioperative complications by E-PASS is higher， which is worth being popularized in clinic use. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Bioactive secondary metabolites of rhizosphere fungiPenicilliumsp. XYR-9 ofCynanchum bungeiDecne Fujin LV, Daqing KONG, Jingzhi QU, Xijin LIU, Xiaoyu LI, Guojun PAN Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 647-651. DOI:10.3969/j.issn.2097-0005.2023.09.002 Abstract（ 126） HTML（ 9） PDF（pc）（1586KB）（ 117） Knowledge map Save ObjectiveTo study a new natural product with good antibacterial activity from the rhizosphere fungiPenicilliumsp. XYR-9 ofCynanchum bungei Decneand provide a theoretical guidance and a material basis for the discovery of novel antibacterial lead compounds with high efficiency and low toxicity.MethodsOn the basis of optimizing the fermentation conditions， rice culture medium was used as the optimal fermentation scheme to enrich the secondary metabolites， further isolated and purified by activity-oriented and the monomer compounds were confirmed by nuclear magnetic resonance and mass spectrometry methods.ResultsFive indole diterpenoids were isolated， identified， and tested for antibacterial activity. The antimicrobial activity of compounds 1， 3 and 5 was tested， and the results showed that the MIC values of compounds 1， 3 and 5 against the standard strains ofS.aureusATCC33591 were 95.70， 106.40 and 118.65 mg·L-1respectively， and 54.12， 43.54 and 42.74 mg·L-1against the standard strains ofE.coliATCC25922.ConclusionThe five indole terpenes obtained fromPenicilliumsp. XYR-9 secondary metabolite， antimicrobial activity tests indicate that these compounds have weak antibacterial activity against bacteria. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Research progress of chimeric antigen receptor T cells therapy for colorectal cancer Chirong LONG, Lu ZHANG, Shang PENG, Jingting MIN, Zhenghong LI Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 682-686. DOI:10.3969/j.issn.2097-0005.2023.09.009 Abstract（ 125） HTML（ 8） PDF（pc）（426KB）（ 29） Knowledge map Save Currently， the clinical treatment methods for colon cancer are still mainly surgery and chemotherapy. However， the traditional therapies have many limitations， including drug resistance， cancer recurrence and severe adverse reactions. Immunology has made great breakthroughs in the treatment of colon cancer， among which chimeric antigen receptor T cell （CAR-T） therapy is the most significant. CAR-T cell therapy is a new genetically engineered immunotherapy method for cancer， which has made great progress in the treatment of tumors. This paper reviews the advantages and limitations of CAR-T cell therapy， from potential targets for colon cancer treatment to preclinical studies and clinical trials. Reference|Related Articles|Metrics|Comments（0）

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Identification of novel regulatory dendritic cell subsets in the lung at steady state Suqin BU, Ren LI, Meixiang WANG, Dianhao GUO, Hua TANG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (10): 721-725. DOI:10.3969/j.issn.2097-0005.2023.10.001 Abstract（ 125） HTML（ 12） PDF（pc）（1625KB）（ 63） Knowledge map Save ObjectiveTo identify a novel regulatory dendritic cell （DC） subsets in the lung at steady state.MethodsThe gene expression characteristics of each subset of lung DCs were analyzed by single-cell RNA sequence （scRNA-seq） and bioinformatics analysis techniques； the phenotypic profile of novel regulatory DC subsets in the lung were further analyzed by flow cytometry； in addition， the functional characteristics of novel regulatory DC subsets in the lung were explored in combination with in vitro cell co-culture system and flow cytometry.ResultsSingle cell data showed that there was a population of DC subsets transcriptionally distinct from cDC1， cDC2 and pDCs in lung tissues under steady-state. As this DC subset highly expressed mature DC signature genes， such as Ccr7 and Cd80 as well as negative regulatory genes， such as Cd274， we named them regulatory DCs（DCreg）. Flow analysis data further confirmed the existence of DCreg in lung tissues， which highly expressed costimulatory molecules CD80 and CD86； in vitro cell co-culture experiments showed that functionally lung DCreg could promote Treg production.ConclusionPreliminary discovery shows a novel lung regulatory DC subset in the lung that is independent and distinct from cDC1， cDC2， and pDC， and can promote Treg production in vitro. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Influence of ultrasonic aerosol fumigation of traditional Chinese medicine on early recovery of patients with colorectal cancer Xue ZHANG, Wenhua ZHANG, Zongjie CHEN, Yunhong LIU Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 894-899. DOI:10.3969/j.issn.2097-0005.2023.12.003 Abstract（ 119） HTML（ 10） PDF（pc）（642KB）（ 64） Knowledge map Save ObjectiveTo investigate the influence of ultrasonic aerosol fumigation of traditional Chinese medicine on early recovery of patients with colorectal cancer.MethodsUsing convenient sampling method， 60 patients who underwent colorectal and sigmoid cancer surgery from May to December 2022 in the colorectal and anal surgery department of a Grade-III hospital were selected as the study objects. The experimental group were treated with ultrasonic fumigation with compound yellow cypress liquid and the control group were treated with conventional treatment. The difference of early rehabilitation indexes between the two groups was compared.ResultsThe sense of anal swelling and distension， the time of anal fluid seepage， the first time of getting out of bed， the first time of exhaust gas， the time of urinary catheter indentation and the time of hospital stay in the treatment group were all better than those in the control group， and the difference between the two groups was statistically significant （P< 0.05）. There was statistical difference between the 1st to 4th day after operation and the 6th day after operation in the test group. Compared with the control group， the 1st and 3rd day after operation in the test group was significantly reduced （P< 0.05）. The time of postoperative anal catheter indentation and postoperative defecation in the experimental group were shorter than those in the control group， and there was no statistical significance between the two groups （P> 0.05）.ConclusionUltrasonic aerosol fumigation with traditional Chinese medicine can alleviate postoperative perianal discomfort， shorten postoperative course of colorectal cancer， promote early postoperative recovery of patients， and provide evidence-based evidence for clinical promotion. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Influence of section orientation of ultrasound shear wave elastography on the measurement of thyroid nodules stiffness Xinru ZHANG, Zhe MA, Shuaiya XU, Chenxi BA, Meng SUN Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 900-903. DOI:10.3969/j.issn.2097-0005.2023.12.004 Abstract（ 117） HTML（ 6） PDF（pc）（882KB）（ 26） Knowledge map Save ObjectiveTo assess the effect of transverse and longitudinal sections on shear wave elastography （SWE） measurements of thyroid nodule stiffness.MethodsA total of 67 patients （79 nodules） who underwent thyroid ultrasound examination in our hospital from February 2022 to November 2022 and underwent SWE examination for all nodules were included in this study. All patients had pathological results obtained through either fine-needle aspiration or surgical biopsy， which allowed the nodules to be classified as benign or malignant. The study aimed to compare the maximum elastic modulus （Emax） and mean elastic modulus （Emean） between benign and malignant nodules in both transverse and longitudinal shear wave elastography. Receiver operating characteristic （ROC） curves were constructed， and the area under the curve （AUC） was calculated to assess the diagnostic performance of SWE in different directions for distinguishing benign and malignant thyroid nodules. The Cronbach reliability coefficient and Bland-Altman plot were used to analyze the reliability and consistency of SWE in both transverse and longitudinal directions for diagnosing thyroid nodules.ResultsThe transverse and longitudinal elastic modulus values of malignant thyroid nodules were higher than those of benign nodules. The differences in Emax and Emean values in transverse and longitudinal sections were not statistically significant for benign nodules， but they were statistically significant for malignant nodules. The ROC analysis showed that the AUC values for Emax and Emean in longitudinal shear wave elastography were 0.955 and 0.939， respectively， while the AUC values for Emax and Emean in transverse shear wave elastography were 0.942 and 0.930， respectively. There was no statistically significant difference in the diagnostic performance （AUC） between these two measurements. Cronbach's reliability analysis of Emax and Emean for SWE in cross-sectional and longitudinal sections of 79 thyroid nodules showed a good correlation （reliability coefficient values of 0.941， 0.943）. The Bland-Altman plots visually showed that the values of the elastic modulus in the transverse and longitudinal sections had almost no deviation over a wide range， indicating a good level of agreement in the data.ConclusionThe section orientation （transverse and longitudinal sections） shows good agreement and reliability for SWE measurements of maximum and mean modulus values of thyroid nodules. The similar performance of the two imaging orientations provides examination flexibility for imaging patients with anatomical or physiological limitations. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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The diagnostic value and clinical significance of the detection of neutrophil CD64 in infectious diseases Hong ZHANG, Qinghua LIU Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (10): 797-800. DOI:10.3969/j.issn.2097-0005.2023.10.016 Abstract（ 116） HTML（ 5） PDF（pc）（412KB）（ 20） Knowledge map Save Serious infection is one of the causes of high mortality. The existing infection indicators， such as PCT and CRP， have certain limitations. In recent years， studies have found that CD64 is an early diagnostic indicator of infectious diseases with high sensitivity， specificity and stability. More and more research results show that CD64 index has a broad prospect in clinical diagnosis. This paper reviews the diagnostic value and clinical significance of CD64 index in infectious diseases. Reference|Related Articles|Metrics|Comments（0）

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Effects of physical activity and novel coronavirus infection on parathyroid hormone in patients undergoing thyroid surgery Guanghan WU, Qian ZHANG, Guoqing ZHANG, Mengchao XU, Lei QIU, Xiang LI, Linquan SHAO, Changping GU, Yuelan WANG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (10): 757-760. DOI:10.3969/j.issn.2097-0005.2023.10.007 Abstract（ 115） HTML（ 5） PDF（pc）（498KB）（ 98） Knowledge map Save ObjectiveTo explore the effect of physical activity and SARS-CoV-2 infection on parathyroid hormone （PTH） levels in patients undergoing thyroid surgery.MethodsPatients undergoing thyroid surgery at the First Affiliated Hospital of Shandong First Medical University from January 2019 to March 2023 were selected. The patients' physical activity levels were assessed using the International Physical Activity Questionnaire， and the metabolic equivalent of task （MET） values were calculated. Among them， 27 patients were infected with novel coronavirus （COVID-19 group） and 197 patients were negative for novel coronavirus （non-COVID-19 group）. The preoperative PTH levels and postoperative day 1 PTH levels of the patients were analyzed using Spearman’s correlation to evaluate the relationship between physical activity， SARS-CoV-2 infection， and PTH levels in thyroid surgery patients.ResultsThere were significant differences in preoperative PTH levels， postoperative PTH levels， and postoperative minus preoperative PTH values between the COVID-19 group and non-COVID-19 group （P< 0.05）. The correlation coefficients between physical activity MET values and preoperative PTH levels， postoperative PTH levels， and postoperative minus preoperative PTH values were not statistically significant （P> 0.05）.ConclusionNovel coronavirus infection can lead to a decrease in preoperative and postoperative PTH levels in surgical patients， while physical activity has no significant impact on PTH levels in thyroid surgery patients with novel coronavirus infection. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Study on the relationship between diabetes kidney diseas and thyroid functionn Mei LIANG, Jianye JIANG, Ruikui MAO, Xiaopang RAO Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 670-674. DOI:10.3969/j.issn.2097-0005.2023.09.006 Abstract（ 115） HTML（ 7） PDF（pc）（567KB）（ 60） Knowledge map Save ObjectiveTo study the relationship between thyroid hormone level and diabetes kidney disease （DKD）.MethodsThis study retrospectively analyzed the patients with diabetes （DM） and the healthy people who received medical examination in the Department of Endocrinology， Chengyang District People's Hospital， Qingdao from March to September 2019， including 250 cases of DM with normal proteinuria （DM group）， 250 cases of DM with microalbuminuria （microalbuminuria group）， and 250 cases of DM with clinical albuminuria （clinical albuminuria group）. The control group was 250 healthy people who received medical examination. The anthropometric indexes such as systolic blood pressure， diastolic blood pressure， height and weight were collected. Collect the blood glucose， blood lipids， serum creatinine （Scr）， thyroid stimulating hormone （TSH）， free triiodothyronine （FT3） and free thyroxine （FT4） of the subjects who were tested after 8-10 hours of fasting， collect and take the morning random urine to test the urine creatinine and urine microalbumin， and calculate the urine albumin/creatinine （UACR） and estimated glomerular filtration rate （eGFR）， and compare the differences and correlations between the groups.ResultsThere was a statistically significant difference in TSH levels among the four groups （P< 0.001）， with the trend of clinical albuminuria group > microalbuminuria group > DM group > control group； There was a statistically significant difference in the levels of FT3 and FT4 among the four groups （P< 0.001）. The trend was that the clinical albuminuria group < microalbuminuria group < DM group < control group. The results of rank correlation analysis showed that the positive correlation of TSH level with Scr and UACR in microalbuminuria group showed statistical difference （P< 0.001）， and the negative correlation with eGFR showed statistical difference （P< 0.001）； The positive correlation between FT3 level and the levels of Scr， UACR and eGFR in microalbuminuria group showed statistical difference （P< 0.001）； The positive correlation between TSH level and Scr and UACR in clinical albuminuria group showed statistical difference （P< 0.001）， and the negative correlation with eGFR showed statistical difference （P< 0.001）； The positive correlation between the levels of FT4， FT3 and the levels of Scr， UACR and eGFR in clinical albuminuria group showed statistical differences （P< 0.001）.ConclusionDKD is accompanied by the increase of TSH level and the decrease of FT3 and FT4 levels， and the abnormality of these hormone levels is more significant with the aggravation of renal damage. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Research progress of contrast-enhanced ultrasound combined with O-RADS in the diagnosis of ovarian tumors Ruijuan LI, Yanhong MENG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 712-715. DOI:10.3969/j.issn.2097-0005.2023.09.015 Abstract（ 113） HTML（ 5） PDF（pc）（435KB）（ 80） Knowledge map Save Ovarian tumors are common gynecological malignant tumors with diverse histopathological manifestations. Early diagnosis is crucial to improve the survival rate of patients. For some tumors with unclear malignant indications， contrast-enhanced ultrasound and other comprehensive evaluation are needed. The author summarizes the literature on contrast-enhanced ultrasound and ovarian-adnexal reporting and data system （O-RADS） in the diagnosis of ovarian tumors， and describes the latest progress in the differential diagnosis of ovarian tumors in order to carry out better clinical work. Reference|Related Articles|Metrics|Comments（0）

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Efficacy and safety analysis of dexamethasone sodium phosphate combined with imipenem and tigecycline in the treatment of sepsis Jinmeng CHEN, Jie XU, Kun LU, Shibing ZHAO Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (10): 743-747. DOI:10.3969/j.issn.2097-0005.2023.10.005 Abstract（ 113） HTML（ 5） PDF（pc）（504KB）（ 16） Knowledge map Save ObjectiveTo analyze the efficacy and safety of dexamethasone sodium phosphate combined with imipenem and tigecycline in the treatment of patients with sepsis.MethodsA total of 150 sepsis patients treated in the First Affiliated Hospital of Bengbu Medical College from March 2019 to March 2022 were collected as research subjects， and randomly divided into two groups， with 75 cases in each group. The control group was treated with imipenem + tigecycline， and the observation group was treated with dexamethasone + imipenem + tigecycline. The curative effect was evaluated， and the serum inflammatory factors and renal function of the two groups were compared before and after treatment. Indicators， levels of myocardial injury markers， adverse reactions such as gastrointestinal reactions and nervous system reactions in patients during the administration period were counted.ResultsThe efficacy was significantly higher in observation group than that in the control group （P< 0.05）. After treatment， the serum inflammatory factors ［interleukin-6 （IL-6）， C-reactive protein （CRP）］ levels of the observation group were significantly lower than those of the control group group （P< 0.05）； levels of renal function indexes ［serum creatinine （Scr） and blood urea nitrogen （BUN）］ and myocardial injury markers ［phosphocreatine kinase （CK）， lactate dehydrogenase （LDH）］ in the observation group were significantly lower than thos in the control group after treatment （P< 0.05）； there was no significant difference in the total incidence of adverse reactions between the two groups （P> 0.05）.ConclusionThe treatment of dexamethasone sodium phosphate combined with imipenem and tigecycline in patients with sepsis can significantly down-regulate the levels of serum inflammatory factors and reduce the damage of heart and kidney function， with definite curative effect and high safety. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Investigation on the habitat and resistance ofCulex tritaeniorhynchusin Weishan Lake area Ziwei LOU, Xiuxia GUO, Yiting WANG, Linlin YANG, Wenqian WANG, Maoqing GONG, Peng CHENG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 675-678. DOI:10.3969/j.issn.2097-0005.2023.09.007 Abstract（ 112） HTML（ 4） PDF（pc）（555KB）（ 68） Knowledge map Save ObjectiveTo investigate and determine the breeding ground species and drug resistance ofCulex tritaeniorhynchusin Weishan Lake area， so as to provide scientific basis for rational selection and use of pesticides and prevention and control of Japanese encephalitis.MethodsFrom July to September 2022， the larvae ofCulex tritaeniorhynchuswere collected by scooping method at the monitoring point in Weishan Lake area. The resistance of the larvae ofCulex tritaeniorhynchusto four commonly used insecticides was tested according to the larval impregnation method recommended by the World Health Organization， and the resistance level of adult mosquitoes was determined by the contact tube method.ResultsThe larvae ofCulex tritaeniorhynchusmainly breed in rice fields and irrigation canals. The resistance multiples to dichlorvos， propoxur， deltamethrin， and cypermethrin were 6.53， 3.27， 98.75 and 295.50 respectively. The resistance to deltamethrin and cypermethrin was the highest， showing a high resistance， while the resistance to dichlorvos and propoxur turned into a medium resistance. When the adult mosquitoes ofCulex tritaeniorhynchuswere exposed to 0.05% deltamethrin， 0.15% cypermethrin， 0.5% malathion and 0.1% propoxur for 1h respectively， the 24 h mortality rates were 21.05%， 19.35%， 45.45% and 94.11% respectively.ConclusionTheCulex tritaeniorhynchusin Weishan Lake area has developed resistance to four commonly used insecticides， among which pyrethroid insecticides have the highest resistance level. The local vector control department should reasonably select and use insecticides to better control the mosquito vector density and the epidemic of infectious diseases. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Research progress of serum markers in the detection of early gastric cancer Yuqi WANG, Jian GE, Na CHEN Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences 2024, 45 (6): 372-377. DOI:10.3969/j.issn.2097-0005.2024.06.010 Abstract（ 112） HTML（ 12） PDF（pc）（483KB）（ 38） Knowledge map Save Gastric cancer is the most common gastric malignant tumor， and the incidence is getting higher in our country. Most patients are diagnosed with gastric cancer when it is in the advanced stage with poor treatment effect and high mortality. The therapeutic effect and prognosis of patients with early gastric cancer are better than those with advanced gastric cancer， so early diagnosis and treatment become the key to the diagnosis and treatment of gastric cancer. At present， the gold standard for the diagnosis of early gastric cancer is biopsy， which is invasive， painful to patients， expensive and easy to miss， so it is not suitable as a screening method. Detection of serum markers， a non-invasive method， provides a new strategy for the diagnosis of early gastric cancer. This article reviews the progress of serum markers in the detection of early gastric cancer. Reference|Related Articles|Metrics|Comments（0）

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A study on the risk factors of white matter lesions and their correlation with cognitive functions Chenglong LIU, Xiying HE, Tong ZHAO, Canwen ZHANG, Weifu ZHANG, Hongyan XIE Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences 2024, 45 (2): 83-89. DOI:10.3969/j.issn.2097-0005.2024.02.004 Abstract（ 110） HTML（ 5） PDF（pc）（612KB）（ 17） Knowledge map Save ObjectiveTo investigate the risk factors for different degree of white matter lesions （WML） and analyze the correlation between WML and cognitive functions.MethodsClinical data and blood indicators of WML patients admitted to the Neurology Department of the Second Affiliated Hospital of Shandong First Medical University from February 2022 to February 2023 were selected， and brain magnetic resonance imaging was performed on them. At the same time， Neuropsychological assessments such as the Montreal cognitive assessment scale （MoCA）， minimal mental state examination Scale （MMSE）， activities of daily living scale（ADL）， Hamilton anxiety scale （HAMA）， the Hamilton depression scale （HAMD） were completed. According to the Fazekas scoring scale， patients were divided into no WML group， mild WML group， moderate WML group， and severe WML group. The clinical data， blood indicators， MoCA related cognitive domain scores， MoCA total score， MMSE score， ADL score， HAMA score， HAMD score of the four groups were compared， the risk factors for different degrees of WML patients were analyzed. To analyze the correlation between different degrees of WML and cognitive impairment. According to the location of WML， related data was divided into normal control group， lateral ventricle peripheral white matter lesion （PVL） group and deep brain white matter lesion （DWML） group.ResultsThere were significant differences among the four groups in age， hypertension， diabetes， coronary heart disease， cerebral infarction， smoking history， and hyperhomocysteinemia （P<0.05）. By ordinal logistic regression analysis， age， hypertension， diabetes， and hyperhomocysteinemia were the risk factors for different degrees of WML patients （P<0.05）. Comparison of cognitive impairment in patients with different degrees of WML： There was no significant difference in cognitive function between the mild WML group and the non WML group. The differences in MoCA total score， visual space and executive function， and attention score between the moderate to severe WML group and the non WML group were statistically significant （P<0.001）. Comparison of cognitive impairment among WML patients in different regions： The total MoCA score of the DWML group was significantly lower than that of the PVL group， and the directional ability and delayed recall function of the DWML group were significantly reduced （P<0.05）. The predictive value of WML for cognitive impairment： Based on the MoCA to evaluate patients’ cognitive functions， the ROC curve analysis using Fazekas scores to predict cognitive impairment in patients indicates that moderate WML have a certain predictive value for the occurrence of cognitive impairment.ConclusionAge， hypertension， diabetes and hyperhomocysteinemia are the risk factors for different degrees of WML patients. The severity and location of WML are correlated with cognitive impairment， which has predictive value for the occurrence and development of cognitive impairment. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Relationship between bacterial imbalance and endometriosis Liujing HOU, Jiating LI, Yuyan WEI, Jingyan JIANG Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences 2024, 45 (6): 361-366. DOI:10.3969/j.issn.2097-0005.2024.06.008 Abstract（ 109） HTML（ 15） PDF（pc）（477KB）（ 40） Knowledge map Save Being a common and frequently occurring gynecological disease， Endometriosis （EMS） seriously affects women's reproductive health and quality of life. Actually， the etiology and pathogenesis of EMS are still unclear at present. Research has revealed that patients suffering EMS have an imbalance in their microbiota， which participates the formation and development of EMS through mechanisms such as inflammation， immune， endocrine， and metabolic effects. Microbial balance is a key factor in maintaining normal local barrier function， and restoring bacterial homeostasis is beneficial for improving the prognosis of EMS patients. This article reviews the research progress on EMS and bacterial imbalance， hoping to provide new ideas for the clinical diagnosis and treatment of patients with EMS. Reference|Related Articles|Metrics|Comments（0）

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The anti-inflammatory effect of integrated traditional Chinese and Western medicine pulmonary rehabilitation strategy on patients with chronic obstructive pulmonary disease Qian HAN, Wenwen CAO, Danting ZHAO, Qiling YIN Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 904-909. DOI:10.3969/j.issn.2097-0005.2023.12.005 Abstract（ 109） HTML（ 6） PDF（pc）（600KB）（ 32） Knowledge map Save ObjectiveTo investigate the efficacy and safety of integrated traditional Chinese and Western medicine pulmonary rehabilitation strategy for patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）.MethodsA total of 132 patients with AECOPD admitted to The Second Affiliated Hospital of Shandong First Medical University from May 2020 to June 2022 were selected as the study subjects. All patients were randomly divided into control group， acute phase group， and stable phase group by the method of random number table， with 44 cases in each group. The control group received routine treatment， the acute phase group received integrated traditional Chinese and Western medicine pulmonary rehabilitation strategy during the acute phase， and the stable phase group received integrated traditional Chinese and Western medicine pulmonary rehabilitation strategy after the disease stabilized in the stable phase. The activities of daily life， lung function， inflammatory factor levels， psychological status， and adverse reactions of the three groups of patients before and after treatment were compared.ResultsThe activities of daily life， lung function， inflammatory factor levels， and psychological status of the three groups of patients were significantly improved after treatment （P< 0.05）， and the improvement of the stable phase group and the acute phase group was more obvious than that of the control group （P< 0.05）， but there was no significant difference between the stable phase group and the acute phase group （P> 0.05）. There was no significant difference in the incidence of adverse reactions among the three groups during the treatment process （P> 0.05）.ConclusionIntegrated traditional Chinese and Western medicine pulmonary rehabilitation strategy has significant therapeutic value for COPD patients， which can effectively inhibit inflammatory response， improve lung function， enhance exercise capacity， improve quality of life and psychological status， and does not increase the risk of adverse events. In addition， integrated traditional Chinese and Western medicine pulmonary rehabilitation strategy should be implemented as early as possible to achieve the best rehabilitation effect. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Study on the effect of family adjustment on medical care delay in breast cancer patients Ni XI, Weinan HU, Ziwei LEI, Wenhao YAN, Jincheng XIAO Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 910-916. DOI:10.3969/j.issn.2097-0005.2023.12.006 Abstract（ 109） HTML（ 6） PDF（pc）（539KB）（ 33） Knowledge map Save ObjectiveTo investigate the current situation of family adjustment and delay in breast cancer patients and analyze the relationship between themand provide a theoretical basis for shortening the delay time and improving the survival rate of breast cancer patients.Methodsgeneral situation questionnaire， family intimacy and adaptability scale， Chinese version （family adaptation and cohesion evaluation scales Ⅱ-Chinese version， FACEⅡ-CV） and the self-compiled medical information questionnaire. By convenience sampling methods， 212 patients of breast cancer surgery in breast surgery， general surgery and oncology departments of Anhui Cancer Hospital were selected from January to July 2023. A total of 209 valid questionnaires were collected and effective recovery rate was 98.6%.ResultsThe total delay rate of medical treatment for patients with breast cancer was 52.1%； family intimacy and adaptive dimension scores were （36.84 ± 7.27） and （35.30 ± 6.28） respectively； the univariate analysis showed that the per capita monthly income， poor family and subsistence-allowance faimilywere the related factors of the delay of breast cancer patients （P< 0.01）； the partial correlation analysis showed that family intimacy and adaptive delay of breast cancer patients were negatively correlated （P< 0.05）. The results of multivariate linear regression analysis showed that family intimacy affected the medical delay in breast cancer patients more in the two dimensions of family adjustment.ConclusionFemale breast cancer patients in Anhui Cancer Hospital have serious delay， their family intimacy and adaptability are at a low level， and their family intimacy and adaptability level have a significant negative impact on the delay time. It is suggested that the relevant departments should further popularize the knowledge of the risk factors of breast cancer and breast self-examination， and the medical and nursing staff can try to play the role of family adjustment function to improve the delay of patients' medical treatment. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Role of dexmedetomidine in improving sevoflurane induced developmental brain neurological dysfunction through NR2B/ERK signaling pathway Guohua LI, Fang CAO, Kaikai QI, Zewen GAO, Feng QIU Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 890-893. DOI:10.3969/j.issn.2097-0005.2023.12.002 Abstract（ 107） HTML（ 11） PDF（pc）（586KB）（ 30） Knowledge map Save ObjectiveTo explore the role of dexmedetomidine in improving sevoflurane-induced developmental brain neurological dysfunction through the NR2B/ERK signaling pathway and investigated the underlying mechanisms.MethodsThe selected subjects were 60 rats， which were randomly and equally divided into control group （air group）， sevoflurane anesthesia group （Sevo group）， sevoflurane anesthesia + dexmedetomidine group （Sevo + Dex group）， with 20 mice in each group. The pups in the Sevo and Sevo + Dex groups were exposed to 0.85% sevoflurane for 6 hours and the Sevo + Dex group were injected with DEX for pre-treatment. cognitive and learning and memory function in pups were determined in water maze and field experiments， and western blots were used to measure protein levels of NR2B， phosphorylated ERK in hippocampal tissue.ResultsCompared with the air group， the escape latency of rats in Sevo group and Sevo+Dex group was significantly increased （P< 0.05）， The times of crossing the original platform quadrant and the residence time in the original platform quadrant were significantly decreased （P< 0.05）， and the residence time in the central region was shortened （P< 0.05）. The level of NR2B protein in hippocampus was increased （P< 0.05）， and the level of phosphorylated ERK protein was decreased （P< 0.05）. Compared with the Sevo group， the escape latency of rats in the Sevo+Dex group was shortened （P< 0.05）. The time of crossing the original platform quadrant and the residence time in the original platform quadrant were significantly increased （P< 0.05）， the residence time in the central region was extended （P< 0.05）， and the NR2B protein level in hippocampus was decreased （P< 0.05）. The protein level of phosphorylated ERK was increased （P< 0.05）.ConclusionDex can improve sevoflurane-induced neurological dysfunction in the developmental rat brain by regulating NR2B/ERK signaling. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Research progress of ultrasound in the diagnosis of Metabolic associated fatty liver disease and related diseases Sen WANG, Yixin ZHANG, Yuli ZHAO, Huimin GUO, Li FENG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 691-695. DOI:10.3969/j.issn.2097-0005.2023.09.011 Abstract（ 100） HTML（ 7） PDF（pc）（452KB）（ 63） Knowledge map Save With the improvement of living standards， the prevalence of metabolic associated fatty liver disease （MAFLD） is increasing， and MAFLD has become the most common chronic liver disease. In recent years， people's understanding of MAFLD has gradually deepened， and MAFLD has a high prevalence of type 2 diabetes mellitus （T2DM）， a significant proportion of them have non-alcoholic steatohepatitis （NASH）， people are paying more and more attention to the impact of MAFLD on T2DM-related complications， such as diabetic nephropathy， cardiovascular disease.and with the development of some new technologies in ultrasound， ultrasound is gradually being used in these complications. At present， ultrasound is the most common imaging method for the diagnosis of MAFLD and liver fibrosis， and this paper mainly reviews the diagnosis of MAFLD by ultrasound and the new progress of ultrasound in patients with MAFLD and T2DM. Reference|Related Articles|Metrics|Comments（0）

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Analysis of the pregnancy outcomes and influencing factors of emergency cervical cerclage for singleton and twin pregnancy Zongxin SUN, Xin LV, Chunlei TIAN, Hao FENG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 665-669. DOI:10.3969/j.issn.2097-0005.2023.09.005 Abstract（ 97） HTML（ 4） PDF（pc）（451KB）（ 91） Knowledge map Save ObjectiveTo investigate the pregnancy outcomes after emergency cervical cerclage for singleton and twin pregnancy women and to analyze the influencing factors.MethodsThe clinical data of 109 patients with single and twin pregnancy who underwent emergency cervical cerclage in Qianfoshan Hospital of Shandong Province in 2022 were retrospectively analyzed.ResultsUsing univariate analysis the differences between the two groups of success and failure in singleton pregnancies，were statistically significant （P <0.05） in terms of polycystic ovary syndrome （PCOS）， adverse maternal history， postoperative premature rupture of membranes （PROM）， degree of dilatation of the uterine orifice and preoperative C-reactive protein （CRP）， Multivariate logistic analysis showed that degree of dilatation （OR= 8.262）， and circumcision gestational week （OR= 0.062） were independent influencing factors on the outcome of emergency cervical cerclage surgery （P <0.05）； among pregnant women with twin pregnancies， the differences were statistically significant （P <0.05） in terms of postoperative CRP levels and circumcision gestational week in both groups， and multifactorial logistic analysis showed that postoperative CRP （OR= 7.056） level was an independent factor influencing the outcome of emergency cervical cerclage in twin pregnancies （P <0.05）.ConclusionEmergency cervical cerclage is an important tool to prevent late miscarriage and preterm delivery in singleton and twin pregnancies Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Smac mimics and treatment of breast cancer Yuli ZHAO, Yixin ZHANG, Sen WANG, Huimin GUO, Li FENG Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 702-706. DOI:10.3969/j.issn.2097-0005.2023.09.013 Abstract（ 95） HTML（ 6） PDF（pc）（427KB）（ 111） Knowledge map Save Second mitochondria-derived activator of caspase （Smac） protein is a natural antagonist of inhibitor of apoptosis protein （IAP） present in mitochondria.Smac protein is released from mitochondria during tumor cell apoptosis and binds to IAP to inhibit its function. Smac mimetics have now emerged as a promising class of targeted therapies in cancer and are being tested in the clinic.Breast cancer is the most common cancer among women in the world， and its treatment is widely concerned.In this review， the research progress related to Smac mimics in breast cancer treatment is summarized. Reference|Related Articles|Metrics|Comments（0）

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Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 923-927. DOI:10.3969/j.issn.2097-0005.2023.12.008 Abstract（ 94） HTML（ 6） PDF（pc）（3843KB）（ 22） Knowledge map Save Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Research rogress on the mechanism of ferroptosis and its relationship with the pathogenesis of gastric cancer Hang YU, Rui GUAN, Jie CHAI Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 955-960. DOI:10.3969/j.issn.2097-0005.2023.12.016 Abstract（ 93） HTML（ 11） PDF（pc）（454KB）（ 30） Knowledge map Save Ferroptosis is a novel form of programmed cell death that is different from apoptosis， autophagy， and cell necrosis， driven by iron-dependent lipid peroxidation. Its main features are intracellular accumulation of free iron， accumulation of reactive oxygen species （ROS）， and lipid peroxidative damage of iron-dependent membrane structures. In recent years， studies have shown that ferroptosis has an important impact on malignant tumors such as liver cancer， colorectal cancer， kidney cancer， ovarian cancer， and thyroid cancer. However， there are relatively few studies on gastric cancer. This article summarizes in detail the occurrence and regulation mechanism of ferroptosis， and expounds the research status and treatment prospect of ferroptosis in the treatment of gastric cancer. Reference|Related Articles|Metrics|Comments（0）

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Influential factors of cerebral edema after intravascular treatment of acute ischemic stroke Yanping SHEN, Zhichao LI, Yanxin ZHAO Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 696-701. DOI:10.3969/j.issn.2097-0005.2023.09.012 Abstract（ 91） PDF（pc）（461KB）（ 122） Knowledge map Save Acute ischemic stroke has high disability and lethality. When acute large blood vessel occlusion causes cerebral infarction， endovascular treatment can quickly open the occluded vessels， realize ischemia tissue reperfusion， timely rescue ischemic penumbra， and improve the prognosis of patients. However， some patients still have malignant cerebral edema after endovascular treatment， and have a high mortality rate.To investigate the influencing factors of malignant cerebral edema after endovascular treatment of acute ischemic stroke，the pathogenesis of cerebral edema， the imaging markers and the effects of time window， neutrophil count， collateral circulation， blood glucose level， glycosylated hemoglobin and B-type natriuretic peptide on cerebral edema are reviewed， and explores the early clinical intervention methods are explored to provide theoretical basis for clinical treatment. Reference|Related Articles|Metrics|Comments（0）

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Research progress of Single cell RNA sequencing in myocarditis Kaiyin GUO, Bo HAN Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (10): 775-778. DOI:10.3969/j.issn.2097-0005.2023.10.012 Abstract（ 88） HTML（ 4） PDF（pc）（420KB）（ 20） Knowledge map Save Myocarditis is an inflammation of the myocardial tissue caused by infection， immunity， and poisoning. Despite that， the clear pathogenesis and a non-invasive， specific diagnosis remain elusive. Single cell sequencing is a new technique for sequencing and analyzing related genomics at the level of a single cell， which can reveal gene expression changes and the characteristics of a single cell. It has great advantages in identifying new cell types， mapping cell development and differentiation， exploring cell population cooperation and predicting gene regulation mechanisms. This paper introduces the progress of single cell sequencing and its research progress in myocarditis， and looks forward to its future development prospects. Reference|Related Articles|Metrics|Comments（0）

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Research on comorbidity of mild cognitive impairment and sarcopenia among old people in rural areas of Anhui Province Yiwei ZHENG, Yan ZHANG, Jingya ZHANG, Qing WANG, Xu LOU, Ren CHEN, Guodong SHEN Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 917-922. DOI:10.3969/j.issn.2097-0005.2023.12.007 Abstract（ 87） HTML（ 2） PDF（pc）（1182KB）（ 23） Knowledge map Save ObjectiveTo screen elderly people aged 60 and above in rural areas of Anhui Province for mild cognitive impairment （MCI） and sarcopenia， to understand the prevalence and influencing factors of comorbidity of MCI and sarcopenia among rural elderly people， and to provide a basis for formulating strategies for joint prevention and management of the two.MethodsConvenient sampling was used to select 2 ~ 3 natural villages from rural areas of Huoshan County and Linquan County in Anhui Province， and eligible subjects were invited to conduct research in the selected areas. Binary logistic regression was used to score the influencing factors of the comorbidity. Data analysis and plotting were completed using SPSS and Stata software.ResultsAge， gender， depression， ADL score， and BMI were the influencing factors of comorbidity of MCI and sarcopenia. Compared to men， women had a higher risk of comorbidity of MCI and sarcopenia （OR= 2.702， 95%CI： 1.436 - 5.083）. For age increase of each year， the risk of comorbidity of MCI and sarcopenia significantly increased （OR= 1.073， 95%CI： 1.029 - 1.119）. Subjects with depressive symptoms had a higher risk of comorbidity of MCI and possible sarcopenia （OR= 2.764， 95%CI= 1.653 - 4.623）， and those with a higher BMI index had a higher risk of comorbidity （OR= 1.080， 95%CI= 1.018 - 1.146）. However， the higher the ADL score of the study subjects was， the lower the risk of comorbidity was （OR= 0.871， 95%CI： 0.837 - 0.907）.ConclusionThe prevalence of comorbidity of MCI and sarcopenia among elderly people in some rural areas of Anhui Province is relatively high； women and the elderly are important risk factors for comorbidity of MCI and sarcopenia in rural areas； the presence of depressive symptoms and high BMI may increase the risk of comorbidity of MCI and sarcopenia in the elderly， which is a controllable risk based on the nature of the risk factors； higher daily activity ability is associated with lower risk of comorbidity of MCI and sarcopenia. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (9): 679-681. DOI:10.3969/j.issn.2097-0005.2023.09.008 Abstract（ 87） HTML（ 6） PDF（pc）（1517KB）（ 50） Knowledge map Save Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Research progress of serum inflammatory markers in chronic obstructive pulmonary disease Qi CHEN, Liping HAN Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (12): 950-954. DOI:10.3969/j.issn.2097-0005.2023.12.015 Abstract（ 87） HTML（ 6） PDF（pc）（425KB）（ 28） Knowledge map Save Chronic obstructive pulmonary disease （COPD） is a systemic inflammatory disease that is currently the main cause of death worldwide. The main feature of COPD is chronic inflammation of the airways and lung parenchyma， accompanied by incomplete reversible and progressive airflow restriction. Numerous studies have confirmed that cytokines and various inflammatory markers play a crucial role in the acute and frequent exacerbation of chronic obstructive pulmonary disease， such as cytokines interleukin-6 （IL-6）， interleukin-8（IL-8）， interleukin-10（IL-10）， and tumor necrosis factor （TFN-α）， interferon-γ （IFN-γ） and inflammatory markers such as C-reactive protein， procalcitonin， neutrophil to lymphocyte ratio （NLR）， and platelet to lymphocyte ratio （PLR） levels. Deep understanding of the role of the aforementioned inflammatory markers in COPD can provide new ideas for its treatment and prevention. Reference|Related Articles|Metrics|Comments（0）

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The effect of attitudes toward own Aging on depression in elderly people： the moderating role of family resilience Jiaomei XUE, Xia SUN, Jing SU, Lihui YANG Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences 2024, 45 (2): 103-107. DOI:10.3969/j.issn.2097-0005.2024.02.007 Abstract（ 87） HTML（ 2） PDF（pc）（813KB）（ 11） Knowledge map Save ObjectiveTo explore the relationship between attitudes toward own aging and depression in elderly people and the moderating role of family resilience.MethodsThe Simplified Attitudes to Ageing Questionnaire， the Family Hardiness Index， and the Patient Health Questionnaire-9 were used to conduct a questionnaire survey of 386 community-dwelling elderly people in Shandong Province.ResultsNegative attitudes toward own aging significantly and positively predicted total depression scores； Control moderated the relationship between attitudes toward own aging and depression （β= -0.166，P< 0.001）， and the effect of attitudes toward own aging on depression was more pronounced in older adults with low control scores （β= 0.862，P< 0.001） than with high control scores （β= 0.372，P< 0.001）. Challenge moderated between self-aging attitudes and depression （β= 0.101，P= 0.028）. The effect of self-aging attitudes on depression in older adults was more significant when challenge scores were at high levels （β=0.652，P=0.000） than the effect when challenge scores were at low levels （β= 0.327，P= 0.009）.ConclusionThe attitude of elder people toward own aging can influence their levels of depression， which are moderated by levels of control and challenge in family resilience. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Analysis of the prevalence of metabolic syndrome in the medical examination population of a tertiary hospital in Anhui province Haoyu WANG, Dian ZHOU, Huan BAI, Di TIAN, Yuan ZHOU, Ye WU, Yu ZHANG, Yaoyao LIU, Manchen LV, Tongbin XUE, Xuezhen LIU Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences 2024, 45 (1): 24-28. DOI:10.3969/j.issn.2097-0005.2024.01.005 Abstract（ 85） HTML（ 2） PDF（pc）（452KB）（ 3） Knowledge map Save ObjectiveTo understand the detection of metabolic syndrome in the population of a tertiary hospital and analyze its epidemiological characteristics， so as to provide a basis for guiding the prevention and treatment work in this region.MethodsA total of 8，381 adults who participated in medical check-ups in a tertiary hospital in 2022 were selected as the study subjects， and data on age， gender， height， weight， fasting blood glucose， blood lipids， blood pressure and other medical check-ups were collected to compare the detection rate of metabolic syndrome and its components in the different genders and age groups of medical check-ups.ResultsThe detection rate of metabolic syndrome in the study population was 13.47%， including 18.18% in men and 6.73% in women， which was higher in men than in women （P< 0.005）， and it also showed an increasing trend with age. The detection rates of the four components of metabolic syndrome were 34.51% （obesity）， 33.06% （dyslipidemia）， 26.27% （hypertension）， and 17.79% （hyperglycaemia）， with dyslipidemia and obesity being more commonly detected than hypertension and hyperglycaemia.ConclusionThe detection rate of metabolic syndrome in the adult health check-up population of a tertiary hospital in Anhui Province should not be underestimated， and intervention efforts should be strengthened in high-risk groups and healthy lifestyles should be promoted with a view to reducing the occurrence of metabolic syndrome. Table and Figures|Reference|Related Articles|Metrics|Comments（0）

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Progress in the exploration of the application of hydrogen in skin diseases Yijun CHEN, Boyan LIU, Jiahui WU, Zhichao LIU Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences 2023, 44 (10): 769-774. DOI:10.3969/j.issn.2097-0005.2023.10.011 Abstract（ 85） HTML（ 2） PDF（pc）（568KB）（ 24） Knowledge map Save As a new biomedical effect gas with great safety， hydrogen （H2） has attracted a widespread attention in the application of skin diseases. This paper reviews the experimental research progress of H2in more than ten kinds of skin diseases， such as psoriasis， skin tumor， type I hypersensitivity reaction， ultraviolet damage， acute inflammatory erythema and so on. The relevant mechanisms such as selective scavenging of ROS， the inhibition of inflammatory molecules， and the regulation of specific signaling pathways are discussed. Meanwhile， the methods of H2-application are discussed. The purpose of this review is to provide a scientific reference for the clinical application of H2in skin diseases. Reference|Related Articles|Metrics|Comments（0）