Table of Content

25 June 2024, Volume 45 Issue 6

Previous Issue Next Issue

For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

Clinical Researches

Select

Relationship between physiologic capacity and surgical stress score on perioperative complications of radical hepatectomy in patients with primary hepatocellular carcinoma

Lijun TIAN, Yujie SANG, Xueyan LI, Wanhui XU, Jiaqi JIANG, Chengyong QIN, Jianni QI

2024, 45(6): 321-325. DOI: 10.3969/j.issn.2097-0005.2024.06.001

Asbtract( ) HTML( ) PDF(477KB) ( )

Figures and Tables| References| Related Articles| Metrics

ObjectiveTo study the relationship between physiologic ability and surgical stress score （E-PASS） and perioperative complications of radical hepatectomy in patients with primary liver cancer.Methods124 primary hepatocellular carcinoma patients admitted to our hospital from March 2022 to May 2023 were retrospectively selected as the study subjects， all of whom underwent radical hepatectomy in our hospital. The perioperative complications of these patients were statistically analyzed， and then they were divided into two groups based on the presence or absence of complications， namely the occurrence group （n= 29） and the non-occurrence group （n= 95）. The clinical data and disease-related characteristics of the two groups of patients were compared and E-PASS evaluation was conducted. The multifactorial Logistic regression equation was taken to analyze the relationship between perioperative complications of radical hepatectomy and various indictors， and then ROC curve graphs were drawn to predict the value of E-PASS in evaluating perioperative complications of radical hepatectomy in patients with primary liver cancer.ResultsA total of 124 patients were included in this paper who underwent radical hepatectomy， and 29 patients （23.39%） had perioperative complications， including 2 cases of liver failure （1.61%）， 6 cases of pleural effusion （4.84%）， 4 cases of abdominal abscess （3.23%）， 8 cases of postoperative hemorrhage （6.45%）， and 9 cases of abdominal cavity infection （7.26%）. In addition， patients with no complications were 95 cases （76.61%）. The difference between the occurrence group and the non-occurrence group was significant in terms of age， intraoperative bleeding， preoperative total bilirubin， and preoperative albumin （P< 0.05）. The preoperative risk score （PRS）， surgical stress score （SSS）， and composite risk score （CRS） scores were all higher in the occurrence group than those in the non-occurrence group （P< 0.05）. After multifactorial logistic regression analysis， it was found that PRS， SSS， and CRS would all have a significant positive influence relationship on perioperative complications of radical hepatectomy in patients with primary hepatocellular carcinoma （P< 0.05）. Meanwhile， by drawing ROC curves， it was found that E-PASS has certain value in predicting perioperative complications of radical liver resection with AUCs of 0.617， 0.614， and 0.601 respectively.ConclusionThe perioperative complications of primary hepatocellular carcinoma patients after radical hepatectomy are high， which need to be paid attention to. And the value of predicting perioperative complications by E-PASS is higher， which is worth being popularized in clinic use.

Select

A clinical study on the effect of using porcelain bonded bridge to repair III deep single anterior tooth loss

Mei CHAI, chenchen Huang, Shengnan XIA, Yuhua WANG

2024, 45(6): 326-330. DOI: 10.3969/j.issn.2097-0005.2024.06.002

Asbtract( ) HTML( ) PDF(1596KB) ( )

Figures and Tables| References| Related Articles| Metrics

ObjectiveTo evaluate the clinical efficacy of porcelain bonded bridge in repairing patients with deep overbite and single anterior tooth loss.MethodsThirty patients with deep overbite and single anterior tooth loss who were treated in our hospital from January 2023 to June 2023 were selected as the study subjects. A cast ceramic adhesive bridge was made on the lip side. The restoration detachment， restoration fracture， edge sealing， secondary caries， edge staining， and periodontal health status were examined one week and six months after surgery，ResultsThe restoration effect was good one week after surgery， with no loss or breakage of the restoration body， good edge closure， no discoloration， and healthy periodontium. After 6 months of examination， 2 cases of restoration were found to have fallen off. After rebonding， they continued to be used. One probe could detect the edge， with mild gingival inflammation. The remaining 27 cases showed no abnormalities， and there was no loss or fracture of the restoration. The edge fit was good， and the abutment teeth had no caries， and the periodontium was healthy.ConclusionThe short-term clinical effect of using porcelain bonded bridge to repair deep overbite with single anterior tooth loss is good.

Select

Study on the clinical effect of six-step microscopical varicocelectomy

Hao ZHONG, Wei LI, Zhiqing FANG, Yongzhen ZHANG, Ze GAO, Zhaoxin GUO, Liwei MENG, Zhaoxu LIU

2024, 45(6): 331-335. DOI: 10.3969/j.issn.2097-0005.2024.06.003

Asbtract( ) HTML( ) PDF(1342KB) ( )

Figures and Tables| References| Related Articles| Metrics

ObjectiveTo investigate the clinical effect of six-step microscopic varicocelectomy.MethodsThere is a retrospective analysis of 102 patients with varicocele underwent microscopic varicocelectomy from September 2021 to December 2022，47 patients in the control group （from September 2021 to June 2022） underwent routine microscopic varicocelectomy， and 55 patients in the observation group （from July 2022 to to December 2022） underwent microscopic varicocelectomy based on the six-step method.The indicators of surgery and surgical complications of the two groups were compared.ResultsThe operation time of observation group（32.54 ± 1.68）min was shorter than control group（47.76 ± 1.43）min， and the difference between the two groups was significant（P< 0.05）。There was no significant difference between two groups in terms of preoperative indexes， intraoperative other indexes（the amount of internal spermatic vein complexes，operation time， intraoperative bleeding），postoperative indexes（P> 0.05）.ConclusionBased on the six-step method， the microscopic spermatic vein ligation by establishing the correct surgical level， standardizing the surgical steps and procedures， thus reducing the operation time， effectively ligation the veins and preserving the arteries and lymphatics， with fewer postoperative complications and good clinical efficacy.

Select

Survey on nutritional status of elderly inpatients and analysis of nutritional intervention

Jianbao WANG, Hongyu ZHANG

2024, 45(6): 336-340. DOI: 10.3969/j.issn.2097-0005.2024.06.004

Asbtract( ) HTML( ) PDF(464KB) ( )

Figures and Tables| References| Related Articles| Metrics

ObjectiveTo analyze the relationship between nutritional intervention and clinical prognosis by studying the nutritional status and nutritional intervention in elderly hospitalized patients.MethodsThe miniature nutritional assessment-short form （MNA-SF） was used to assess the nutritional risk and nutritional status of patients who were admitted to a Grade-A tertiary hospital in Shandong Province （hereinafter referred to as our department） from August 2020 to July 2021 and met the inclusion criteria， and to obtain the nutritional interventions during hospitalization， and to statistically analyze the clinical prognosis of the patients after nutritional interventions.Results422 patients were included in the study， of whom 156 patients were at nutritional risk （malnutrition + risk of malnutrition） with a prevalence of 36.9%， and the prevalence increases with age and number of disease types. All patients with malnutrition received nutritional intervention （50/50） and none of the patients with normal nutrition received nutritional intervention （0/266）. Among the patients who received nutritional intervention， enteral nutrition （EN） was the main mode of intervention， and the application ratio of EN， parenteral nutrition （PN）， and combined nutrition （EN+PN） was 1.68∶1.00∶1.09. 67 patients received the 2nd nutritional risk assessment after 1 week of admission， and 42 patients received the 3rd nutritional risk assessment after 2 weeks. The results of the 2 assessments showed that the patients who received nutritional intervention had significant improvement in nutritional indicators （prealbumin， hemoglobin， and lymphocyte count）.ConclusionElderly hospitalized patients have a high incidence of nutritional risk， and rational nutritional intervention has a significant effect on the improvement of nutritional status of elderly patients， and it is extremely important to select appropriate nutritional interventions in an individualized and detailed way.

Public Health & Preventive Medicine

Select

Correlation analysis between short-term exposure to air pollution and blood glucose in hypertensive patients in Hefei City

Jiuying HU, Juan WU, Xinran DING

2024, 45(6): 341-350. DOI: 10.3969/j.issn.2097-0005.2024.06.005

Asbtract( ) HTML( ) PDF(1556KB) ( )

Figures and Tables| References| Related Articles| Metrics

ObjectiveEpidemiological studies have shown that air pollution exposure has been associated with abnormal blood glucose， but limited studies have examined the associations in hypertensive patients. We aimed to examine the associations of exposure to air pollution with blood glucose in hypertensive patients.MethodsWe had identified patients who were previously diagnosed as hypertension from the records of physical examination data of a tertiary hospital in Anhui Province from January to December 2021. We has used generalized additive models to estimate adverse effects of air pollution on blood glucose in hypertensive patients. A total of 8 913 patients were enrolled in this study.ResultsThe results showed that short-term exposure to O₃was significantly and positively correlated with blood glucose levels in hypertensive patients. Specifically， it was statistically significant at Lag6 to Lag15 and Lag0 - 8 to Lag0 - 15. The O₃had the greatest effect on blood glucose in hypertensive patients when the cumulative lag was 15 days （lag0 - 15）. For every 10 μg/m³increase of the concentration O₃， the abnormal blood glucose increased by 16.8% （95%CI： 1.056 - 1.291）. In addition， the stratified analyses by gender， age， and body mass index （BMI） showed that O₃had a more significant effect on blood glucose in females， those in the ≥ 60 years age group， and those with weight in the normal range.ConclusionIn Hefei， the elevated levels of air pollution O₃is significantly associated with the increase of abnormal blood glucose levels in the hypertensive population. Among hypertensive patients， females， the elderly， and those of normal weight are more susceptible to O₃.

Select

Epidemiological analysis of active monitoring results of foodborne diseases in Taian from 2019 to 2023

Guodong SHI, Bing LIU, Yong QI

2024, 45(6): 351-356. DOI: 10.3969/j.issn.2097-0005.2024.06.006

Asbtract( ) HTML( ) PDF(872KB) ( )

Figures and Tables| References| Related Articles| Metrics

ObjectiveUnderstand and master the epidemic trends of the main pathogens of foodborne diseases， and provide a basis for the formulation of prevention and control measures for foodborne diseases in Taian.MethodsStatistical analysis of case information and pathogen detection results reported through the foodborne disease active monitoring system in Taian from 2019 to 2023.ResultsThe detection rate of pathogens was 28.11% from 2019 to 2023， and the highest rate was 45.02% after the COVID-19 （2023）；The detection rates of various pathogens from high to low were Norovirus （13.50%）， Salmonella （10.54%）， Escherichia coli causing diarrhea （3.61%）， Vibrio parahaemolyticus （0.46%）， and Shigella was not detected； Bacterial pathogens are more prevalent in summer， with a higher detection rate from May to August. Norovirus is more prevalent in winter and spring， with peak detection rates in November and February； The pathogen detection rate is higher in the group aged 1 to 3 （31.49%） and the group aged 0 to 1 （30.14%）； Farmers （35.54%）， scattered children （31.31%）， and students （30.36%） are the occupations with a high detection rate of pathogens in physical examinations； The exposed foods that cause a high detection rate of pathogens are aquatic animals and their products （43.21%）， eggs and egg products （37.65%）， and fruits and their products （36.63%）； The place with the highest detection rate of pathogens in physical examinations is the home （30.54%）.ConclusionThe pathogen detection rate in Taian varies seasonally， with the main pathogens being Norovirus and Salmonella. The key population is farmers， and the main suspicious foods are aquatic animals and their products. In the future， targeted prevention and control should be carried out according to the high incidence season of the main pathogens， popular science promotion should be carried out for key populations， active monitoring and food supervision should be strengthened， and the risk of foodborne diseases should be reduced.

Reviews

Select

Relationship between bacterial imbalance and endometriosis

Liujing HOU, Jiating LI, Yuyan WEI, Jingyan JIANG

2024, 45(6): 361-366. DOI: 10.3969/j.issn.2097-0005.2024.06.008

Asbtract( ) HTML( ) PDF(477KB) ( )

References| Related Articles| Metrics

Being a common and frequently occurring gynecological disease， Endometriosis （EMS） seriously affects women's reproductive health and quality of life. Actually， the etiology and pathogenesis of EMS are still unclear at present. Research has revealed that patients suffering EMS have an imbalance in their microbiota， which participates the formation and development of EMS through mechanisms such as inflammation， immune， endocrine， and metabolic effects. Microbial balance is a key factor in maintaining normal local barrier function， and restoring bacterial homeostasis is beneficial for improving the prognosis of EMS patients. This article reviews the research progress on EMS and bacterial imbalance， hoping to provide new ideas for the clinical diagnosis and treatment of patients with EMS.

Select

Progress of new ultrasound techniques in the differential diagnosis of thyroid nodules

Guoli ZHANG, Qian YUAN, Xiaohong XU

2024, 45(6): 367-371. DOI: 10.3969/j.issn.2097-0005.2024.06.009

Asbtract( ) HTML( ) PDF(432KB) ( )

References| Related Articles| Metrics

Thyroid nodules are quite common in clinical practice. In recent years， with the continuous progress of ultrasonography technology and people's increasing attention to their own health， the detection rate of thyroid nodules has gradually increased. At the same time， new ultrasound diagnostic techniques such as ultrasonography， microvascular flow imaging， ultrasound elastography and artificial intelligence have been developed in recent years， which have significantly improved the accuracy of benign and malignant diagnosis of thyroid nodules. The purpose of this article is to review the value of new ultrasound technologies in the benign-malignant differential diagnosis of thyroid nodules.

Select

Research progress of serum markers in the detection of early gastric cancer

Yuqi WANG, Jian GE, Na CHEN

2024, 45(6): 372-377. DOI: 10.3969/j.issn.2097-0005.2024.06.010

Asbtract( ) HTML( ) PDF(483KB) ( )

References| Related Articles| Metrics

Gastric cancer is the most common gastric malignant tumor， and the incidence is getting higher in our country. Most patients are diagnosed with gastric cancer when it is in the advanced stage with poor treatment effect and high mortality. The therapeutic effect and prognosis of patients with early gastric cancer are better than those with advanced gastric cancer， so early diagnosis and treatment become the key to the diagnosis and treatment of gastric cancer. At present， the gold standard for the diagnosis of early gastric cancer is biopsy， which is invasive， painful to patients， expensive and easy to miss， so it is not suitable as a screening method. Detection of serum markers， a non-invasive method， provides a new strategy for the diagnosis of early gastric cancer. This article reviews the progress of serum markers in the detection of early gastric cancer.

Select

Advances in the study of antitumor activity and mechanism of biological extract parthenolide

Botao XU, Jie CHAI, Yongsheng WANG

2024, 45(6): 378-384. DOI: 10.3969/j.issn.2097-0005.2024.06.011

Asbtract( ) HTML( ) PDF(497KB) ( )

References| Related Articles| Metrics

Parthenolide， a sesquiterpene lactone extracted from chamomile， is considered a highly potential anticancer candidate drug due to its unique chemical properties and complex molecular effects on various tumor cells. This review focuses on exploring the mechanisms of parthenolide in tumor models， particularly its impact on gene expression， signal transduction， and different types of cell death in tumor cells. The latest research findings reveal that parthenolide can not only effectively inhibit key transcription factors such as NF-κB and STAT-3 but also trigger specific cell death pathways leading to an increase in intracellular reactive oxygen species and changes in Bcl-2 family proteins. Moreover， parthenolide has shown specific targeting capabilities against cancer stem cells. Given the significant efficacy of parthenolide， this compound is promised to be a new drug targeting cancer therapy.