JAK2-STAT3信号通路在肿瘤发生发展中的作用

国际肿瘤学杂志››2021,Vol. 48››Issue (12): 739-742.doi:10.3760/cma.j.cn371439-20210428-00146

JAK2-STAT3信号通路在肿瘤发生发展中的作用

罗盼¹, 曾艳¹, 吴伟莉^1,^2,³()

¹贵州医科大学临床医学院肿瘤学教研室,贵阳 550000
²贵州医科大学附属医院肿瘤科,贵阳 550000
³贵州医科大学附属肿瘤医院头颈肿瘤科,贵阳 550000

收稿日期:2021-04-28修回日期:2021-06-26出版日期:2021-12-08发布日期:2022-01-12
通讯作者:吴伟莉 E-mail:wwlmhy@163.com
基金资助:
贵州省科技计划(黔科合基础〔2017〕)(1148);贵州省教育厅创新群体重大研究项目(黔教合KY字〔2017〕)(038)

Role of JAK2-STAT3 signaling pathway in tumorigenesis and development

Luo Pan¹, Zeng Yan¹, Wu Weili^1,^2,³()

¹Department of Oncology, School of Clinical Medicine, Guizhou Medical University, Guiyang 550000, China
²Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China
³Depart-ment of Head and Neck Oncology, Cancer Hospital Affiliated of Guizhou Medical University, Guiyang 550000, China

Received:2021-04-28Revised:2021-06-26Online:2021-12-08Published:2022-01-12
Contact:Wu Weili E-mail:wwlmhy@163.com

摘要/Abstract

摘要：

JAK2-STAT3信号通路作为细胞内传递信号的主链,在细胞增殖、凋亡、侵袭、迁移及免疫应答等活动中起重要作用。该通路由细胞因子和干扰素触发,能迅速地将细胞外信号转导到细胞核中,在头颈部鳞状细胞癌、肺癌、食管癌、胃癌、肝癌、乳腺癌、骨髓增生性肿瘤等多种肿瘤中存在异常表达。深入了解JAK2-STAT3信号通路的致癌机制,可为临床治疗肿瘤及判断预后提供新的思考。

关键词:肿瘤,JAK2-STAT3信号通路

Abstract:

JAK2-STAT3 signaling pathway, as the main chain of intracellular signal transmission, plays an important role in cell proliferation, apoptosis, invasion, migration and immune response. Triggered by cytokines and interferon, this pathway can quickly transduce extracellular signals into the nucleus, and it has abnormal expression in various tumors, such as squamous cell carcinoma of the head and neck, lung cancer, esophageal cancer, gastric cancer, liver cancer, breast cancer and myeloproliferative neoplasms. Further understanding of the carcinogenic mechanism of JAK2-STAT3 signaling pathway can provide new ideas for clinical treatment of tumors and prognosis.

Key words:Neoplasms,JAK2-STAT3 signaling pathway

罗盼, 曾艳, 吴伟莉. JAK2-STAT3信号通路在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2021, 48(12): 739-742.

Luo Pan, Zeng Yan, Wu Weili. Role of JAK2-STAT3 signaling pathway in tumorigenesis and development[J]. Journal of International Oncology, 2021, 48(12): 739-742.

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