国际肿瘤学杂志››2024,Vol. 51››Issue (7): 458-463.doi:10.3760/cma.j.cn371439-20231130-00075

• 综述 •上一篇下一篇

单细胞视角下的肿瘤浸润免疫细胞

杜启联, 胡钦勇()

  1. 武汉大学人民医院肿瘤中心,武汉 430060
  • 收稿日期:2023-11-30修回日期:2024-04-07出版日期:2024-07-08发布日期:2024-08-14
  • 通讯作者:胡钦勇,Email:rm001223@whu.edu.cn
  • 基金资助:
    武汉大学2021年医学部教学研究项目(2021026)

Tumor-infiltrating immune cells from a single-cell perspective

Du Qilian, Hu Qinyong()

  1. Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Received:2023-11-30Revised:2024-04-07Online:2024-07-08Published:2024-08-14
  • Contact:Hu Qinyong, Email:rm001223@whu.edu.cn
  • Supported by:
    Wuhan University 2021 Medical Department Teaching and Research Project(2021026)

摘要:

免疫微环境与肿瘤的治疗和预后密切相关。肿瘤浸润免疫细胞在肿瘤不同阶段中异质性显著。单细胞RNA测序(scRNA-seq)在单细胞水平解析细胞的生物学行为、机制及其与机体的关系,已广泛应用于各种肿瘤微环境的研究。研究显示,应用scRNA-seq技术能深入剖析肿瘤浸润免疫细胞的免疫特征。

关键词:单细胞分析,淋巴细胞,髓系细胞,肿瘤

Abstract:

Immune microenvironment is closely related to the treatment and prognosis of tumors. Tumor-infiltrating immune cells exhibit significant heterogeneity in different stages of tumors. Single-cell RNA sequencing (scRNA-seq) is widely used in the study of various tumor microenvironment to analyze the biological behavior, mechanisms, and relationship between cells and the body at the single-cell level. The results showed that using scRNA-seq can deeply understand the immune characteristics of tumor-infiltrating immune cells.

Key words:Single-cell analysis,Lymphocytes,Myeloid cells,Neoplasms