


国际肿瘤学杂志››2014,Vol. 41››Issue (12): 887-890.doi:10.3760/cma.j.issn.1673-422X.2014.12.003
出版日期:2014-12-24发布日期:2015-02-02通讯作者:钟跃,Email: zhongyue2457@sina.com基金资助:
天津市应用基础与前沿技术研究计划(13JCQNJC10800、13JCZDJC31000)
Online:2014-12-24Published:2015-02-02Contact:Zhong Yue, Email: zhongyue2457@sina.com摘要:微小RNA451(miR451)在胶质瘤、胃癌、结直肠癌和肝癌等多种肿瘤组织中明显低表达。上调 miR451的表达可以显著抑制肿瘤细胞的增殖、侵袭和转移,诱导肿瘤细胞凋亡,提高肿瘤细胞放、化疗敏感性等。
南阳, 钟跃. 微小RNA-451在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2014, 41(12): 887-890.
南Yang , ZHONG Yue. Research progress of miR-451 in tumor[J]. Journal of International Oncology, 2014, 41(12): 887-890.
| [1] Gal H, Pandi G, Kanner AA, et al. MIR451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells[J]. Biochem Biophys Res Commun, 2008, 376(1): 8690. [2] Godlewski J, Nowicki MO, Bronisz A, et al. MicroRNA451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells[J]. Mol Cell, 2010, 37(5): 620632. [3] Godlewski J, Bronisz A, Nowicki MO, et al. microRNA451: A conditional switch controlling glioma cell proliferation and migration[J]. Cell Cycle, 2010, 9(14): 27422748. [4] Zhou X, Ren Y, Moore L, et al. Downregulation of miR21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status[J]. Lab Invest, 2010, 90(2): 144155. [5] Nan Y, Han L, Zhang A, et al. MiRNA451 plays a role as tumor suppressor in human glioma cells[J]. Brain Res, 2010, 1359: 1421. [6] Tian Y, Nan Y, Han L, et al. MicroRNA miR451 downregulates the PI3K/AKT pathway through CAB39 in human glioma[J]. Int J Oncol, 2012, 40(4):11051112. [7] Wang R, Wang ZX, Yang JS, et al. MicroRNA451 functions as a tumor suppressor in human nonsmall cell lung cancer by targeting rasrelated protein 14 (RAB14) [J]. Oncogene, 2011, 30(23): 26442658. [8] Gao W, Shen H, Liu L, et al. MiR21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis[J]. J Cancer Res Clin Oncol, 2011, 137(4): 557566. [9] Bian HB, Pan X, Yang JS, et al. Upregulation of microRNA451 increases cisplatin sensitivity of nonsmall cell lung cancer cell line (A549) [J]. J Exp Clin Cancer Res 2011, 30: 20. [10] Bandres E, Bitarte N, Arias F, et al. microRNA451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells[J]. Clin Cancer Res, 2009, 15(7): 22812290. [11] Zhu C, Ren C, Han J, et al. A fivemicroRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer[J]. Br J Cancer, 2014, 110(9): 22912299. [12] Li HP, Zeng XC, Zhang B, et al. miR451 inhibits cell proliferation in human hepatocellular carcinoma through direct suppression of IKKβ[J]. Carcinogenesis, 2013, 34(11): 24432451. [13] Liu X, Zhang X, Xiang J, et al. miR451: Potential role as tumor suppressor of human hepatoma cell growth and invasion[J]. Int J Oncol, 2014, 45(2): 739745. [14] Li HY, Zhang Y, Cai JH, et al. MicroRNA451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway[J]. Asian Pac J Cancer Prev, 2013, 14(6): 36313634. [15] Shivapurkar N, Weiner LM, Marshall JL, et al. Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs[J]. PLoS One, 2014, 9(1):e84686. [16] Kovalchuk O, Filkowski J, Meservy J, et al. Involvement of microRNA451 in resistance of the MCF7 breast cancer cells to chemotherapeutic drug doxorubicin[J]. Mol Cancer Ther, 2008, 7(7): 21522159. [17] Ji T, Zheng ZG, Wang FM, et al. Differential microRNA expression by Solexa sequencing in the sera of ovarian cancer patients[J]. Asian Pac J Cancer Prev, 2014, 15(4):17391743. [18] Gits CM, van Kuijk PF, Jonkers MB, et al. MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR145 and miR451 as tumor suppressors[J]. Int J Cancer, 2014, 135(2): 348361. [19] Xu H, Mei Q, Shi L, et al. Tumorsuppressing effects of miR451 in human osteosarcoma[J]. Cell Biochem Biophys, 2014, 69(1): 163168. [20] Liu N, Jiang N, Guo R, et al. MiR451 inhibits cell growth and invasion by targeting MIF and is associated with survival in nasopharyngeal carcinoma[J]. Mol Cancer, 2013, 12(1): 123. [21] Wang T, Zang WQ, Li M, et al. Effect of miR451 on the biological behavior of the esophageal carcinoma cell line EC9706[J]. Dig Dis Sci, 2013, 58(3): 706714. [22] Redova M, Poprach A, Nekvindova J ,et al. Circulating miR378 and miR451 in serum are potential biomarkers for renal cell carcinoma[J]. J Transl Med, 2012, 10: 55. [23] Caruso P, MacLean MR, Khanin R, et al. Dynamic changes inlung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline[J]. Arterioscler Thromb Vasc Biol, 2010, 30(4): 716723. [24] Liu D, Liu C, Wang X, et al. MicroRNA451 suppresses tumor cell growth by downregulating IL6R gene expression[J]. Cancer Epidemiol, 2014, 38(1): 8592. |
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