亲环素A在肿瘤中的作用机制

国际肿瘤学杂志››2016,Vol. 43››Issue (6): 439-441.doi:10.3760/cma.j.issn.1673-422X.2016.06.010

陆凯强，周志刚，田雯，邹志楠，廖彩勤，谢飞燕，涂剑

421001 衡阳，南华大学药物药理研究所（陆凯强、田雯、邹志楠、廖彩勤、谢飞燕、涂剑）；南华大学附属第一医院麻醉科（周志刚）

收稿日期:2016-01-11出版日期:2016-06-08发布日期:2016-04-27
通讯作者:涂剑 E-mail:tujian0734@aliyun.com
基金资助:

国家自然科学基金（81541163）；湖南省自然科学基金（2015JJ3101）；湖南省教育厅创新平台开放基金（15K111）；南华大学博士启动基金（2011XQD44）；“湖南省分子靶标新药研究协同创新中心”培育项目（2014，405）

Mechanism of Cyclophilin A in tumor

Lu Kaiqiang, Zhou Zhigang, Tian Wen, Zou Zhinan, Liao Caiqin, Xie Feiyan, Tu Jian

Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China

Received:2016-01-11Online:2016-06-08Published:2016-04-27
Contact:Tu Jian E-mail:tujian0734@aliyun.com
Supported by:

National Natural Science Foundation of China (81541163); Natural Science Foundation of Hunan Province (2015JJ3101); Open Fund Based on Innovation Platform of Hunan Provincial Education Department (15K111); Scientific Research Foundation for Doctors in University of South China (2011XQD44); Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Study (2014，405)

摘要/Abstract

摘要：亲环素A在多种肿瘤细胞中高表达，可通过诱导炎癌转化，加快肿瘤细胞转录周期，促进肿瘤细胞侵袭转移，抑制肿瘤细胞凋亡，以及降低肿瘤细胞对化疗药物的敏感性等多种途径调控多种肿瘤的发生发展，提示亲环素A可能是一种促癌基因，有望成为肿瘤治疗新靶标。

关键词:肿瘤,亲环素A,药理作用分子作用机制

Abstract:Cyclophilin A (CypA) is found to be highly expressed in different kinds of tumor cells, which could regulate the occurrence and development of many kinds of tumor through multiple signal transduction pathways such as inducing the formation of inflammatory carcinoma, accelerating the transcription cycle of tumor cells, promoting the invasion and metastasis of tumor cells, inhibiting the apoptosis of tumor cells and reducing the sensitivity of tumor cells to chemotherapy drugs. It suggests that CypA might be considered as a kind of oncogene, which is expected to be a novel target for tumor treatment.

Key words:Neoplasms,Cyclophilin A,Molecular mechanisms of pharmacological action

陆凯强，周志刚，田雯，邹志楠，廖彩勤，谢飞燕，涂剑. 亲环素A在肿瘤中的作用机制[J]. 国际肿瘤学杂志, 2016, 43(6): 439-441.

Lu Kaiqiang, Zhou Zhigang, Tian Wen, Zou Zhinan, Liao Caiqin, Xie Feiyan, Tu Jian. Mechanism of Cyclophilin A in tumor[J]. Journal of International Oncology, 2016, 43(6): 439-441.

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