协同刺激分子B7-H3与肿瘤

摘要/Abstract

摘要：B7-H3分子是新近发现的协同刺激调节蛋白B7家族成员之一，其mRNA广泛表达于人类各种组织。B7-H3不仅能够作为共刺激或共抑制信号调节免疫反应，在免疫应答中发挥重要作用，而且可以参与肿瘤进展的非免疫调节。近年来研究发现B7H3在多种恶性肿瘤中异常表达并与患者预后不良、疾病进展密切相关，被认为是肿瘤早期诊断、预后判断指标以及临床治疗的分子靶点，但其中涉及的具体机制并不明确。同时，针对B7-H3分子免疫及基因治疗研究取得了一定成效。

关键词:肿瘤,协同刺激分子B7-H3

Abstract:B7-H3, a newly discovered co-stimulatory regulatory protein member of the B7 family. Its mRNA is ubiquitously expressed in a wide spectrum of tissues. As a co-stimulatory or co-inhibitory signal molecule which can regulate immune response, B7-H3 plays an important role in the immune system. Besides, B7-H3 can be also involved in cancer progression via nonimmunological. Recently, the aberrant expression of B7-H3 has been described in various malignancies, and significantly correlated with poor prognosis and cancer progression. Therefore, B7-H3 is considered as an early diagnostic and prognostic marker and therapeutic target for tumors, but the specific molecular mechanisms of B7-H3 regulation are poorly understood. The immune and gene therapy of tumor by target B7-H3 has made some progress.

Key words:Neoplasms,Co-stimulatory molecule B7-H3

朱晓雯，王晶，克晓燕. 协同刺激分子B7-H3与肿瘤[J]. 国际肿瘤学杂志, 2017, 44(11): 849-852.

朱晓雯，王晶，克晓燕. Co-stimulating molecule B7H3 and tumors[J]. Journal of International Oncology, 2017, 44(11): 849-852.

参考文献

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Co-stimulating molecule B7H3 and tumors

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