PD-1/PD-L1抑制剂疗效预测的生物标志物

摘要/Abstract

摘要：随着肿瘤精准免疫治疗的发展，寻找预测程序性死亡受体1（PD1）/程序性死亡配体1（PDL1）响应能力的生物标志物成为该领域研究的一大热点。迄今已有多项预测指标如肿瘤组织PDL1的表达、肿瘤浸润淋巴细胞、肿瘤突变负荷、血清学标记甚至放射学指标在抗PD1/PDL1免疫治疗过程中显现了它们的价值，但每个预测指标都有其局限性。

王阿香，高全立. PD-1/PD-L1抑制剂疗效预测的生物标志物[J]. 国际肿瘤学杂志, 2018, 45(12): 751-755.

Wang Axiang, Gao Quanli. Predictive biomarkers of efficacy to PD-1/PD-L1 inhibitors[J]. Journal of International Oncology, 2018, 45(12): 751-755.

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PD-1/PD-L1抑制剂疗效预测的生物标志物

Predictive biomarkers of efficacy to PD-1/PD-L1 inhibitors

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