国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (6): 406-408.

• 综述 •上一篇下一篇

SUMO化和去SUMO化在肿瘤发生中的作用

胡丹,陈福祥

  1. 上海交通大学医学院附属第九人民医院临床免疫室
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:陈福祥，E-mail:fuxiang_chen@hotmail.com E-mail:fuxiang_chen@hotmail.com
  • 基金资助:

    国家自然科学基金资助项目（81001205）

Roles of SUMOylation and deSUMOylation in carcinogenesis

HU Dan, CHEN Fu-xiang

  1. Department of Clinical Immunology, Ninth People′s Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:CHEN Fu-xiang, E-mail: fuxiang_chen@hotmail.com E-mail:fuxiang_chen@hotmail.com

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被引次数

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摘要：SUMO是一种小泛素相关修饰物，参与蛋白质的翻译后修饰，这一修饰过程即称为SUMO化。SUMO化修饰在加强蛋白质的稳定性、核质转运、DNA的修复和复制、染色体的有丝分裂、减数分裂等调节细胞活动中发挥重要作用。SUMO化是一动态过程，能被SUMO特异性蛋白酶(SENP)所逆转，形成SUMO化与去SUMO化的动态平衡。此平衡一旦被打破，将导致SUMO或者SENP在细胞中的异常表达，进而导致肿瘤的发生。

关键词:SUMO化,氨基酸特征结构,肿瘤

Abstract:SUMO (small ubiquitin-related modifier) is involved in the post-translational modifications of proteins, and this process is referred to as SUMOylation. SUMOylation plays an important role in the regulation of cellular activities such as strengthening the stability of the protein, nucleocytoplasmic transport, DNA repair, DNA replication, mitotic and meiotic chromosome behavior, et al. SUMOylation is a dynamic process and can be reversed by SUMOspecific proteases (SENP). Once the balance between SUMOylation and deSUMOylation is broken, there will be an aberrant expression of SUMO or SENPs in cells to happen, which may lead to the tumor occurrence.

Key words:Sumoylation,Amino acid motifs,Neoplasms