国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (6): 411-414.

• 综述 •上一篇下一篇

转化生长因子-β受体Ⅲ负性调控肿瘤发生的研究

张述升,张飚,王金环

  1. 天津市环湖医院神经外科
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:王金环，E-mail: wangjinhuanfch@yahoo.com.cn E-mail:wangjinhuanfch@yahoo.com.cn
  • 基金资助:

    天津市应用基础及前沿技术研究计划(11JCYBJC12100)

Negative regulation of transforming growth factor-β superfamily co-receptor Ⅲ in tumorigenesis

ZHANG Shu-sheng, ZHANG Biao, WANG Jin-huan

  1. Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:WANG Jin-huan, E-mail: wangjinhuanfch@yahoo.com.cn E-mail:wangjinhuanfch@yahoo.com.cn

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摘要：转化生长因子-β受体（TβR）Ⅲ在多种肿瘤组织中常表达缺失，并能负性调控肿瘤的发生，其机制除了依赖Smads的典型转化生长因子-β（TGF-β）信号通路外，还能通过影响P38丝裂原活化蛋白激酶（MAPK）、转录核因子-κB （NF-κB）、Cdc42以及产生可溶性TβR（sTβR）Ⅲ等多种机制调控肿瘤的侵袭、迁移、增殖和凋亡。进一步明确TβRⅢ在肿瘤组织中表达缺失的机制对肿瘤的诊断、治疗和预后评估意义重大。

关键词:受体,转化生长因子β,信号传导,肿瘤形成过程

Abstract:The expression of transforming growth factor(TGF)-β superfamily co-receptor (TβR)Ⅲ is often lost in many kinds of cancers. TβRⅢ plays a role of negative regulation in tumorigenesis. TβRⅢ could regulate the cellular invasion, migration, proliferation and apoptosis by multiple mechanisms, such as mediating the TGF-β signaling pathway, impacting the mitogenactivated protein kinase(MAPK),nuclear factorkappa B(NF-κB) and Cdc42 and producing soluble TβR(sTβR)Ⅲ. Defining the mechanisms of absence and physiological functions of TβRⅢ in cancers has great significant for the diagnosis, treatment and prognosis of cancer.

Key words:Receptors, transforming growth factor beta,Signal transduction,Neoplastic processes