国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (8): 570-572.

• 综述 •上一篇下一篇

核转录因子-κB与肿瘤上皮间质转化

郑礼平,李志花,陈汝福

  1. 510120 广州，中山大学孙逸仙纪念医院肿瘤科
  • 出版日期:2012-08-29发布日期:2012-08-29
  • 通讯作者:李志花，E-mail:lzhzsdxsyx@126.com E-mail:lzhzsdxsyx@126.com

Nuclear factor-kappa B in epithelial-mesenchymal transition of cancer

ZHENG Li-Ping, LI Zhi-Hua, CHEN Ru-Fu

  1. Department of Oncology, Sun Yat-sen Memorial Hospital, Sun YatSen Universiy, Guangzhou 510120, China
  • Online:2012-08-29Published:2012-08-29
  • Contact:LI Zhi-hua, E-mail: lzhzsdxsyx@126.com E-mail:lzhzsdxsyx@126.com

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摘要：核转录因子-κB（NF-κB）是肿瘤上皮间充质转化（EMT）的重要调节因子。肿瘤发生EMT能够增强肿瘤浸润及远处转移能力，是肿瘤耐药的原因之一。目前研究发现，信号转导因子Snail、Slug、Twist、Zeb等在NF-κB调控肿瘤EMT中起重要作用。药物及靶向干扰NF-κB可以逆转肿瘤EMT。NF-κB有望成为将来肿瘤治疗的有效靶点之一。

关键词:NF-κB,肿瘤,上皮间质转化

Abstract:Nuclear factor-kappa B(NF-κB) is a key regulator in epithelialmesenchymal transition(EMT) of cancer cells. EMT of cancer, one of the reasons of drug resistance, enhances the infiltration and distant metastases ability of cancer cells. Recent researches show that Snail, Slug, Twist and Zeb play important roles in regulating EMT of cancer cells. Drugs and targeted therapies that inhibit NFκB activities can reverse the EMT of cancer cells. NFκB may become an effective therapeutic target in cancers in the future.

Key words:NF-kappa B,Neoplasms,Epithelial mesenchymal transition