国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (8): 622-625.

• 综述 •上一篇下一篇

宫颈癌的术后放化疗

夏怡, 李云海, 赵森

  1. 200240 上海， 复旦大学附属肿瘤医院闵行分院放疗科（夏怡、李云海）； 复旦大学附属肿瘤医院放疗科（赵森）
  • 出版日期:2012-08-29发布日期:2012-08-29
  • 通讯作者:李云海，E-mail：liyunhai@csco.org.cn E-mail:liyunhai@csco.org.cn

Postoperative radiotherapy and chemotherapy in cervical cancer

XIA Yi, LI Yun-Hai, ZHAO Sen

  1. Department of Radiation Oncology, Minhang Branch of Cancer Hospital, Fudan University, Shanghai 200240, China
  • Online:2012-08-29Published:2012-08-29
  • Contact:LI Yun-hai, E-mail: liyunhai@csco.org.cn E-mail:liyunhai@csco.org.cn

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摘要：宫颈癌术后有高危因素患者易局部复发。已经证实有高危因素患者术后行辅助放疗能提高局部控制率，但不能提高总生存率。有研究显示同步放化疗较单纯放疗能提高生存率，但血液及消化系统不良反应较重。调强放疗（IMRT）能提高靶区适形度及剂量，同时降低周围正常组织剂量，IMRT有较好的局部控制率及生存率。

关键词:宫颈肿瘤,放射疗法,药物疗法

Abstract:Local recurrence is more frequent in postoperative cervical cancer patients with high-risk factors. It is confirmed that adjuvant pelvic radiotherapy (RT) for the cervical cancer patients after surgery with high-risk factors can improve local control but can′t improve the overall survival. Researches show that concurrent chemo-radiotherapy (CCRT) can improve survival rates compared with radiotherapy, but the adverse effects such as leucopenia and gastrointestinal toxicity are observed frequently. Intensity-modulated radiation therapy (IMRT) has been developed to deliver a high radiation dose to an irregular target volume, with relative sparing of adjacent normal tissues. IMRT has excellent local tumor control and overall survival.

Key words:Uterine cervical neoplasms,Radiotherapy,Drug therapy