国际肿瘤学杂志››2013,Vol. 40››Issue (11): 839-843.doi:10.3760/cma.j.issn.1673-422X.2013.11.012

• 综述 •上一篇下一篇

分子标志物在食管癌骨髓微转移中的研究进展

马兰, 刘连科

  1. 南京医科大学第一附属医院肿瘤科
  • 出版日期:2013-11-08发布日期:2013-10-15
  • 通讯作者:刘连科, E-mail:liulianke@medmail.com.cn E-mail:liulianke@medmail.com.cn
  • 基金资助:

    江苏省临床医学科技专项(BL2012008)

Molecular markers in the bone marrow micrometastasis of esophageal cancer

MA Lan, LIU Lian-Ke

  1. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2013-11-08Published:2013-10-15
  • Contact:LIU Lian-Ke, E-mail:liulianke@medmail.com.cn E-mail:liulianke@medmail.com.cn

摘要:近年食管癌骨髓微转移逐渐成为研究热点。许多研究显示上皮细胞分子、血管形成相关标志物、趋化因子受体-4(CXCR-4)、HER2基因、活化白细胞黏附分子(ALCAM)及斯钙素-1(STC-1)等分子标志物与食管癌骨髓微转移密切相关,这些分子标志物对食管癌临床诊断、预后判断及指导治疗有重要作用。

关键词:食管肿瘤,肿瘤微转移,肿瘤标记,生物学

Abstract:In recent years, the bone marrow micrometastasis of esophageal cancer has become the research focus. Many studies show that epithelial cell molecules, angiogenesis markers, chemokine receptor-4 (CXCR-4), HER2, activated leukocyte cell adhesion molecule (ALCAM) and stanniocalcin-1 (STC-1) are closely related to the bone marrow micrometastasis of esophageal cancer. These molecular markers play important roles in esophageal cancer diagnosis, prognosis and treatment.

Key words:Esophageal neoplasms,Neoplasm micrometastasis,Tumormarkers,biological