上皮-间质转化及其干性作用与肿瘤

摘要/Abstract

摘要：上皮间质转化（EMT）参与肿瘤转移过程，Twist作为关键调控因子在EMT中发挥重要作用，放疗、化疗和多种细胞因子均可诱导Twist介导的EMT。研究表明，肿瘤细胞可能通过EMT转变为肿瘤干细胞样细胞，并进一步导致放化疗抵抗、肿瘤血管形成及远处转移，对肿瘤的预后产生巨大影响，EMT有望成为肿瘤治疗的重要靶点。

邓春燕, 谭晓琴, 李涛, 黄建鸣. 上皮-间质转化及其干性作用与肿瘤[J]. 国际肿瘤学杂志, 2013, 40(12): 899-902.

DENG Chun-Yan, TAN Xiao-Qin, LI Tao, HUANG Jian-Ming. EMT mediated cancer stemness and tumor[J]. Journal of International Oncology, 2013, 40(12): 899-902.

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上皮-间质转化及其干性作用与肿瘤

EMT mediated cancer stemness and tumor

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