CD47在肿瘤中的表达及治疗应用

摘要/Abstract

摘要：近年来研究发现，CD47通过上调在肿瘤细胞表面的表达来影响肿瘤的生长与转移，同时，其表达上调预示临床预后较差；而CD47单抗可通过激活适应性免疫及直接介导细胞凋亡等机制抑制肿瘤生长。此外，CD47还具有调节血液系统和胃肠道系统正常组织细胞的放射性损伤修复作用，有望成为肿瘤治疗的新靶点。

杜娇娇, 姚辉, 汪延明. CD47在肿瘤中的表达及治疗应用[J]. 国际肿瘤学杂志, 2014, 41(1): 1-4.

DU Jiao-Jiao, YAO Hui, WANG Yan-Ming. Expression and therapeutic application of CD47 in cancer[J]. Journal of International Oncology, 2014, 41(1): 1-4.

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Expression and therapeutic application of CD47 in cancer

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