| ［1］ Koppenol WH, Bounds PL, Dang CV. Otto Warburg′s contributions to current concepts of cancer metabolism［J］. Nat Rev Cancer, 2011, 11(5): 325-337. ［2］ DeBerardinis RJ, Cheng T. Q′s next: the diverse function of glutamine in metabolism, cell biology and cance［J］. Oncogene, 2010, 29(3): 313-324. ［3］ Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology physiology, and clinical opportunities［J］. J Clin Invest, 2013, 123(9): 3678-3684. ［4］ Wise DR, Thompson CB. Glutamine addiction: a new therapeutic target in cancer［J］. Trends Biochem Sci, 2010, 35(8): 427-433. ［5］ Nicklin P, Bergman P, Zhang B, et al. Bidirectional transport of amino acids regulates mTOR and autophagy［J］. Cell, 2009, 136(3): 521-534. ［6］ Jewell JL, Russell RC, GuanKL. Amino acid signaling upstream of mTOR［J］. Nat Rev Mol Cell Biol, 2013, 14(3): 133-139. ［7］ Csibi A, Fendt SM, Li C, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4［J］. Cell， 2013, 153(4): 840-854. ［8］ Qu W, Oya S, Lieberman BP, et al. Preparation and characterization of L［511C］glutamine for metabolic imaging of tumors［J］. J Nucl Med, 2012, 53(1): 98-105. ［9］ Gao P, Tchernyshyov I, Chang TC, et al. cMyc suppression of miR23a/b enhances mitochondrial glutaminase expression and glutamine metabolism［J］. Nature, 2009, 458(7239): 762-765. ［10］ Fuchs BC, Bode BP. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?［J］. Semin Cancer Biol, 2005, 15(4): 254-266. ［11］ van den Heuvel AP, Jing J, Wooster RF, et al. Analysis of glutamine dependency in nonsmall cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth［J］. Cancer Biol Ther, 2012, 13(12):1185-1194. ［12］ Kung HN, Marks JR, Chi JT. Glutamine synthetase is a genetic determinant of cell typespecific glutamine independence in breast epithelia［J］. PLoS Genet, 2011, 7(8): e1002229. ［13］ Wang Q, Beaumont KA, Otte NJ, et al. Targeting glutamine transport to suppress melanoma cell growth［J］. Int J Cancer, 2014, 135(5): 1060-1071. ［14］ Son J, Lyssiotis CA, Ying H, et al. Glutamine supports pancreatic cancer growth through a Kras regulated metabolic pathway［J］. Nature, 2013, 496(7443): 101-105. ［15］ Hassanein M, Hoeksema MD, Shiota M, et al. SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival［J］. Clin Cancer Res, 2013, 19(3): 560-570. ［16］ Wang JB, Erickson JW, Fuji R, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation［J］. Cancer Cell, 2010, 18(3): 207-219. ［17］ Robinson MM, McBryant SJ, Tsukamoto T, et al. Novel mechanism of inhibition of rat kidneytype glutaminase by bis2(5 phenylacetamido1,2,4thiadiazol2yl)ethyl sulfide (BPTES)［J］. Biochem J, 2007, 406(3): 407-414. ［18］ Qing G, Li B, Vu A, et al. ATF4 regulates MYCmediated neuroblastoma cell death upon glutamine deprivation［J］. Cancer Cell, 2012， 22(5): 631-644. ［19］ Thornburg JM, Nelson KK, Clem BF, et al. Targeting aspartate aminotransferase in breast cancer［J］. Breast Cancer Res, 2008, 10(5): R84. ［20］ Robey IF, Stephen RM, Brown KS, et al. Regulationof the Warburg effect in earlypassage breast cancer cells［J］. Neoplasia, 2008, 10(8): 745-756. ［21］ Yu EY, Muzi M, Hackenbracht JA, et al. C11acetate and F18 FDG PET for men ith prostate cancer bone metastases: relative findings and response to therapy［J］. Clin Nucl Med, 2011, 36(3): 192-198. ［22］ Levine AJ, PuzioKuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes［J］. Science, 2010，330(6009): 1340-1344. ［23］ Dinkelborg L, Friebe M, Krasikowa RN, et al. ［18F］ labelled Lglutamic acid, ［18F］ labelled glutamine, their derivatives, their use and processes for their preparation: EP, 1923382［P］. 20080521. ［24］ Kung HF, Thompson CB, Qu WC, et al. Single diastereomers of 4fluoroglutamine and methods for their preparation and use: US, WO2011/020018［P］. 20110217. ［25］ Lieberman BP, Ploessl K, Wang L, et al. PET imaging of glutaminolysis in tumors by 18F(2S,4R)4fluoroglutamine［J］. J Nucl Med, 2011, 52(12): 1947-1955. ［26］ Ploessl K, Wang L, Lieberman BP, et al. Comparative evaluation of 18Flabeled glutamic acid and glutamine as tumor metabolic imaging agents［J］. J Nucl Med, 2012, 53(10): 1616-1624. |
