结肠癌转移相关基因1及其在肿瘤中的作用

国际肿瘤学杂志››2016,Vol. 43››Issue (1): 32-35.doi:10.3760/cma.j.issn.1673-422X.2016.01.009

结肠癌转移相关基因1及其在肿瘤中的作用

郭宏艳,何利珍,张云霏,张虹,金惠琴,安文文

730000 兰州，甘肃省第二人民医院病理科（郭宏艳、张云霏、张虹、金惠琴、安文文）；广州医科大学附属肿瘤医院病理科（何利珍）

收稿日期:2015-05-06出版日期:2016-01-08发布日期:2015-12-03
通讯作者:郭宏艳 E-mail:pinghongrui@126.com
基金资助:

甘肃省卫生行业科研计划（GSWSKY-2015-17）

Metastasis-associated in colon cancer 1 and its role in cancer

Guo Hongyan, He Lizhen, Zhang Yunfei, Zhang Hong, Jin Huiqin, An Wenwen

Department of Pathology , Second People′s Hospital of Gansu Province, Lanzhou 730000, China

Received:2015-05-06Online:2016-01-08Published:2015-12-03
Contact:Guo Hongyan E-mail:pinghongrui@126.com
Supported by:

Health Industry Scientific Research Plan of Gansu Province of China (GSWSKY-2015-17)

摘要/Abstract

摘要：结肠癌转移相关基因1（MACC1）编码的蛋白质在肝细胞生长因子/肝细胞生长因子受体（HGF/cMet）信号转导通路中转录激活cMet基因，上调cMet蛋白的表达，促进肿瘤细胞的侵袭和转移。MACC1蛋白高表达与人类多种肿瘤的发生和转移相关，如结肠癌、胃癌、肝癌、肺癌、卵巢癌等，且与肿瘤临床分期、有无远处转移密切相关，可作为肿瘤转移和预后判断的独立指标，为基因治疗提供新靶点。

关键词:结肠肿瘤,结肠癌转移相关基因1,原癌基因蛋白质c-Met

Abstract:The protein product of metastasis-associated in colon cancer 1 (MACC1) gene induces the activation of hepatocyte growth factor/mesenchymalepithelial transition factor (HGF/c-Met) signaling pathway through transcriptionally activating cMet gene and upregulating its expression to further promote tumor invasion and metastasis. High level expression of MACC1 is associated with the occurrence and metastasis of a wide variety of human tumors, such as colon cancer, gastric cancer, liver cancer, lung cancer, ovarian cancer etc. In addition, the overexpression of MACC1 is also closely associated with clinical TNM stages and distant metastasis. Thus, MACC1 can serve as an independent indicator of tumor metastasis and prognosis, and become a new target for gene therapy.

Key words:Colonic neoplasms,Metastasis-associated in colon cancer 1,Proto-oncogene proteins c-Met

郭宏艳,何利珍,张云霏,张虹,金惠琴,安文文. 结肠癌转移相关基因1及其在肿瘤中的作用[J]. 国际肿瘤学杂志, 2016, 43(1): 32-35.

Guo Hongyan, He Lizhen, Zhang Yunfei, Zhang Hong, Jin Huiqin, An Wenwen. Metastasis-associated in colon cancer 1 and its role in cancer[J]. Journal of International Oncology, 2016, 43(1): 32-35.

参考文献

［1］ Stein U, Walther W, Arlt F, et al. MACC1, a newly identified key regulator of HGFMET signaling, predicts colon cancer metastasis［J］. Nat Med, 2009, 15(1): 59-67. DOI:10.1038/nm.1889. ［2］ Stein U, Dahlmann M, Walther W. MACC1 more than metastasis? Facts and predictions about a novel gene［J］. J Mol Med, 2010, 88(1): 11-18. DOI:10.1007/s00109-009-0537-1. ［3］刘清泉, 刘青光, 昝献峰, 等. MACC1基因在肝细胞癌中的表达及临床意义［J］. 华中科技大学学报: 医学版, 2010, 39(1): 22-28. DOI:10.3870/j.issn.1672-0741.2010.01.006. ［4］ Yao Y, Dou C, Lu Z, et al. MACC1 suppresses cell apoptosis in hepatocellular carcinoma by targeting the HGF/cMET/AKT pathway［J］. Cell Physiol Biochem, 2015, 35(3): 983996. DOI:10.1159/000369754. ［5］ Juneja M, Ilm K, Schlaga PM, et al. Promoter identification and transcriptional regulation of the metastasis gene MACC1 in colorectal cancer［J］. Mol Oncol, 2013, 7(5): 929-943. DOI:10.1016/j.molonc.2013.05.003. ［6］ Stein U, Smith J, Walther W, et al. MACC1 controls Met: what a difference an Sp1 site makes［J］. Cell Cycle, 2009, 8(15): 2467-2469. ［7］ Skead G, Govender D. Gene of the month: MET［J］. J Clin Pathol, 2015, 68(6): 405-409. DOI:10.1136/jclinpath2015-203050. ［8］ Zlobec I. Novel biomarkers for the prediction of metastasis in colorectal cancer［J］. Expert Opin Med Diagn, 2013, 7(2): 137-146. DOI:10.1517/17530059.2013.753054. ［9］ Ren B, Zakharov V, Yang Q, et al. MACC1 is related to colorectal cancer initiation and earlystage invasive growth［J］. Am J Clin Pathol, 2013, 140(5): 701-707. DOI:10.1309/AJCPRH1H5RWWSXRB. ［10］ Sueta A, Yamamoto Y, YamamotoIbusuki M, et al. Differential role of MACC1 expression and its regulation of the HGF/c-Met pathway between breast and colorectal cancer［J］. Int J Oncol, 2015, 46(5): 2143-2153. DOI:10.3892/ijo.2015.2907. ［11］ Stein U, Burock S, Herrmann P, et al. Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis［J］. PLoS One, 2012, 7(11): e49249. DOI:10.1371/journal.pone.0049249. ［12］ Schmid F, Burock S, Klockmeier K, et al. SNPs in the coding region of the metastasisinducing gene MACC1 and clinical outcome in colorectal cancer［J］. Mol Cancer, 2012, 11: 49. DOI:10.1186/1476-4598-11-49. ［13］ Kawamura M, Saigusa S, Toiyama Y, et al. Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy［J］. Anticancer Res, 2012, 32(4): 15271531. ［14］ Lang AH, GellerRhomberg S, Winder T, et al. A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients［J］. BMC Cancer, 2012, 12: 20. DOI:10.1186/1471-2407-12-20. ［15］ Shirahata A, Shinmura K, Kitamura Y, et al. MACC1 as a marker for advanced colorectal carcinoma［J］. Anticancer Res, 2010, 30(7): 2689-2692. ［16］ Wang L, Wu Y, Lin L, et al. Metastasisassociated in colon cancer1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion［J］. Int J Cancer, 2013, 133(6): 1419-1430. DOI:10.1002/ijc.28140. ［17］ Ge SH, Wu XJ, Wang XH, et al. Overexpression of metastasisassociated in colon cancer1 (MACC1) associates with better prognosis of gastric cancer patients［J］. Chin J Cancer Res, 2011, 23(2): 153-159. DOI:10.1007/s11670-011-0153-9. ［18］ Shirahata A, Sakata M, Kitamura Y, et al. MACC1 as a marker for peritonealdisseminated gastric carcinoma［J］. Anticancer Res, 2010, 30(9): 3441-3444. ［19］王妮娜, 谢剑明, 郑大勇, 等. 稳定表达MACC1的胃癌BGC823/pBaBbpuroMACC1细胞株的建立及其肿瘤相关基因的研究基因［J］. 南方医科大学学报, 2012, 32(3): 312-316. DOI: CNKI:44-1627/R.20120307.1708.024. ［20］ Qiu J, Huang P, Liu Q, et al. Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma［J］. J Transl Med, 2011, 9: 166. DOI:10.1186/1479-5876-9-166. ［21］ Yang YP, Qu JH, Chang XJ. High intratumoral metastasisassociated in colon cancer1 expression predicts poor outcomes of cryoablation therapy for advanced hepatocellular carcinoma［J］. J Transl Med, 2013, 11: 41. DOI:10.1186/1479-5876-11-41. ［22］ Gao J, Ding F, Liu Q, et al. Knockdown of MACC1 expression suppressed hepatocellular carcinoma cell migration and invasion and inhibited expression of MMP2 and MMP9［J］. Mol Cell Biochem, 2013, 376(1-2): 21-32. DOI:10.1007/s11010-012-1545-y. ［23］ Qu JH, Chang XJ, Lu YY, et al. Overexpression of metastasisassociated in colon cancer 1 predicts a poor outcome of hepatitis B virusrelated hepatocellular carcinoma［J］. World J Gastroenterol, 2012, 18(23): 29953003. DOI:10.3748/wjg.v18.i23.2995. ［24］ Shirahata A, Fan W, Sakuraba K, et al. MACC1 as a marker for vascular invasive hepatocellular carcinoma［J］. Anticancer Res, 2011, 31(3): 777-780. ［25］丁飞虎, 高洁, 韩少山, 等. MACC1蛋白在肝细胞癌中的表达水平及其与患者预后的关系［J］. 华中科技大学学报: 医学版, 2013, 42(4): 464-468. DOI:10.3870/j.issn.1672-0741.2013.04.021. ［26］ Chundong G, Uramoto H, Onitsuka T, et al. Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis［J］. Anticancer Res, 2011, 31(4): 1141-1145. ［27］ Shimokawa H, Uramoto H, Onitsuka T, et al. Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence［J］. J Thorac Cardiovasc Surg, 2011, 141(4): 895-898. DOI:10.1016/j.jtcvs.2010.09.044. ［28］杨淑慧, 龙摇敏, 王摇希, 等. MACC1基因siRNA对肺癌SBC5细胞增殖和迁移的影响［J］. 现代肿瘤医学, 2011, 19(4):633-636. DOI:10.3969/j.issn.16724992.2011.04.04. ［29］胡兴胜, 付曦, 文世民, 等. MACC1和cmet在非小细胞肺癌中的表达及其预后价值［J］. 中国肺癌杂志, 2012, 15(7): 399-403. DOI:10.3779/j.issn.10093419.2012.07.02. ［30］ Zhang R, Shi H, Chen Z, et al. Effects of metastasisassociated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR3 cells［J］. J Exp Clin Cancer Res, 2011, 30: 83. DOI:10.1186/1756-9966-30-83. ［31］张瑞涛，史惠蓉，黄好亮, 等. MACC1、HGF和Cmet蛋白在卵巢上皮性癌中的表达及其意义［J］. 南方医科大学学报, 2011, 31(9): 1551-1555.

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