浆细胞瘤转化迁移基因1在肿瘤中的研究进展

摘要/Abstract

摘要：浆细胞瘤转化迁移基因（PVT1）是一个重要的长非编码RNA，在人类基因组PVT1定位于染色体8q24.21。PVT1的异常表达和多态性与人类多种肿瘤如恶性淋巴瘤、乳腺癌、结直肠癌、胰腺癌等密切相关，并能影响肿瘤患者的生存和预后。目前认为其作用机制可能是通过与Myc基因、微小RNA或其他蛋白的相互作用，以及基因多态性等，但还不明确，对PVT1的深入研究有望为肿瘤的诊断治疗提供新靶点。

彭娟菲, 张世能. 浆细胞瘤转化迁移基因1在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2016, 43(2): 141-.

PENG Juan-Fei, ZHANG Shi-Neng. Plasmacytoma variant translocation 1 in cancer[J]. Journal of International Oncology, 2016, 43(2): 141-.

［1］ Fatica A, Bozzoni I. Long noncoding RNAs: new players in cell differentiation and development［J］. Nat Rev Genet, 2014, 15(1): 721. DOI:10.1038/nrg3606. ［2］ Kung JT, Colognori D, Lee JT. Long noncoding RNAs: past, present, and future［J］. Genetics, 2013, 193(3): 651669. DOI:10.1534/genetics.112.146704. ［3］ Qiu MT, Hu JW, Yin R, et al. Long noncoding RNA: an emerging paradigm of cancer research［J］. Tumor Biol, 2013, 34(2): 613620. DOI:1007/s1327701306586. ［4］ Guan Y, Kuo WL, Stilwell JL, et al. Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer［J］. Clin Cancer Res, 2007, 13(19): 57455755. DOI:10.1158/10780432.CCR062882. ［5］ Yang YR, Zang SZ, Zhong CL, et al. Increased expression of the lncRNA PVT1 promotes tumorigenesis in nonsmall cell lung cancer［J］. Int J Clin Exp Pathol, 2014, 7(10): 69296935. ［6］ Ding J, Li D, Gong M, et al. Expression and clinical significance of the long noncoding RNA PVT1 in human gastric cancer［J］. OncoTargets Ther, 2014, 7: 16251630. DOI:10.2147/OTT.S68854. ［7］ Takahashi Y, Sawada G, Kurashige J, et al. Amplification of PVT1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers［J］. Br J Cancer, 2014, 110(1): 164171. DOI:10.1038/bjc.2013.698. ［8］ Cory S, Graham M, Webb E, et al. Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the cmyc oncogene［J］. EMBO J, 1985, 4(3): 675681. ［9］ Shtivelman E, Bishop JM. The PVT gene frequently amplifies with MYC in tumor cells［J］. Mol Cell Biol, 1989, 9(3): 11481154. ［10］ Sen R, Ghosal S, Das S, et al. Competing endogenous RNA: the key to posttranscriptional regulation［J］. Sci World J, 2014, 2014: 896206. DOI:10.1155/2014/896206. ［11］ Tseng YY, Moriarity BS, Gong W, et al. PVT1 dependence in cancer with MYC copynumber increase［J］. Nature, 2014, 512(7512): 8286. DOI:10.1038/nature13311. ［12］ Barsotti AM, Beckerman R, Laptenko O, et al. p53dependent Induction of PVT1 and miR1204［J］. J Biol Chem， 2012, 287(4): 25092519. DOI:10.1074/jbc.M111.322875. ［13］ Paci P, Colombo T, Farina L. Computational analysis identifies a sponge interaction network between long noncoding RNAs and messenger RNAs in human breast cancer［J］. BMC Syst Biol, 2014, 8: 83. DOI:10.1186/17520509883. ［14］ EncisoMora V, Broderick P, Ma Y, et al. A genomewide association study of Hodgkin′s lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)［J］. Nat Genet, 2010, 42(12): 11261130. DOI:10.1038/ng.696. ［15］ Cerhan JR, Berndt SI, Vijai J, et al. Genomewide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma［J］. Nat Genet, 2014, 46(11): 12331238. DOI:10.1038/ng.3105. ［16］ Skibola CF, Berndt SI, Vijai J, et al. Genomewide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region［J］. Am J Hum Genet, 2014, 95(4): 462471. DOI:10.1016/j.ajhg.2014.09.004. ［17］ Meyer KB, Maia A, O′Reilly M, et al. A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression［J］. PLoS Genet, 2011, 7(7): e1002165. DOI:10.1371/journal.pgen.1002165. ［18］ Zhang Z, Zhu Z, Zhang B, et al. Frequent mutation of rs13281615 and its association with PVT1 expression and cell proliferation in breast cancer［J］. J Genet Genomics, 2014, 41(4): 187195. DOI:10.1016/j.jgg.2014.03.006. ［19］ Wang F, Yuan JH, Wang SB, et al. Oncofetal long noncoding RNA PVT1 promotes proliferation and stem celllike property of hepatocellular carcinoma cells by stabilizing NOP2［J］. Hepatology, 2014, 60(4): 12781290. DOI:10.1002/hep.27239. ［20］ Liu E, Liu Z, Zhou Y. Carboplatindocetaxelinduced activity against ovarian cancer is dependent on upregulated lncRNA PVT1［J］. Int J Clin Exp Pathol, 2015, 8(4): 38033810. ［21］ Zhang XW, Bu P, Liu L, et al. Overexpression of long noncoding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance［J］. Biochem Biophys Res Commun, 2015, 462(3): 227232. DOI:10.1016/j.bbrc.2015.04.121. ［22］ Kong R, Zhang EB, Yin DD, et al. Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16［J］. Mol Cancer, 2015, 14: 82. DOI:10.1186/s1294301503558. ［23］ Cao WJ, Wu HL, He BS, et al. Analysis of long noncoding RNA expression profiles in gastric cancer［J］. World J Gastroenterol, 2013, 19(23): 36583664. DOI:10.3748/wjg.v19.i23.3658. ［24］ Ding C, Yang Z, Lv Z, et al. Long noncoding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients［J］. Oncol Lett, 2015, 9(2): 955963. DOI:10.3892/ol.2014.2730. ［25］ You L, Chang D, Du HZ, et al. Genomewide screen identifies PVT1 as a regulator of Gemcitabine sensitivity in human pancreatic cancer cells［J］. Biochem Biophys Res Commun, 2011, 407(1): 16. DOI:10.1016/j.bbrc.2011.02.027. ［26］ Iwakawa R, Takenaka M, Kohno T, et al. Genomewide identification of genes with amplification and/or fusion in small cell lung cancer［J］. Genes Chromosomes Cancer, 2013, 52(9): 802816. ［27］ Riquelme E, Suraokar MB, Rodriguez J, et al. Frequent coamplification and cooperation between CMYC and PVT1 oncogenes promote malignant pleural mesothelioma［J］. J Thorac Oncol, 2014, 9(7): 9981007. DOI:10.1097/JTO.0000000000000202. ［28］ Nagoshi H, Taki T, Hanamura I, et al. Frequent PVT1 rearrangement and novel chimeric genes PVT1NBEA and PVT1WWOX occur in multiple myeloma with 8q24 abnormality［J］. Cancer Res, 2012, 72(19): 49544962. DOI:10.1158/00085472.CAN120213. ［29］ Macchia G, Lonoce A, Venuto S, et al. A rare but recurrent t(8;13)(q24;q14) translocation in Bcell chronic lymphocytic leukaemia causing MYC upregulation and concomitant loss of PVT1, miR15/16 and DLEU7［J］. Br J Haematol, 2015, In press. DOI:10.1111/bjh.13482.

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浆细胞瘤转化迁移基因1在肿瘤中的研究进展

Plasmacytoma variant translocation 1 in cancer

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