姜黄素逆转P-糖蛋白介导的多药耐药机制

摘要/Abstract

摘要：多药耐药（MDR）是临床药物抗癌失败的重要原因之一，涉及多种机制。其中，P糖蛋白（Pgp）介导的经典MDR机制与MDR的形成关系密切，通过“药泵”效应排出细胞内化疗药物，显著降低化疗疗效。姜黄素主要提取自中药姜黄的地下根茎，具有广泛的药理活性。近年研究发现，姜黄素通过调控多种信号通路，抑制Pgp的功能和表达，发挥逆转肿瘤MDR的作用。

关键词:姜黄素,P糖蛋白,多药耐药,信号通路

Abstract:Multidrug resistance (MDR) is one of the important reasons for the failure of clinical anticancer drugs, involving multiple mechanisms. Among them, the classical MDR mechanism mediated by Pglycoprotein (Pgp) is closely related to the formation of MDR, which can excrete intracellular chemotherapeutic drugs through the "drug pump" effect and significantly reduce the therapeutic effect. Curcumin is mainly extracted from the underground rhizome of Chinese medicine turmeric, with a wide range of pharmacological activity. Recent studies have found that curcumin also has a role in reversing the MDR of the tumor, by inhibiting both Pgp function and expression, and this process involves a variety of signal paths.

Key words:Curcumin,P-glycoprotein,Multidrug resistance,Signal path

刘兰,张志敏,彭文苗,付红星,饶智国. 姜黄素逆转P-糖蛋白介导的多药耐药机制[J]. 国际肿瘤学杂志, 2017, 44(10): 758-761.

Liu Lan, Zhang Zhimin, Peng Wenmiao, Fu Hongxing, Rao Zhiguo. Reversal of Pglycoproteinmediated multidrug resistance mechanism by curcumin[J]. Journal of International Oncology, 2017, 44(10): 758-761.

参考文献

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