抗PD-1/PD-L1免疫治疗生物标志物研究进展

国际肿瘤学杂志››2019,Vol. 46››Issue (1): 40-44.doi:10.3760/cma.j.issn.1673-422X.2019.01.009

抗PD-1/PD-L1免疫治疗生物标志物研究进展

王欢¹,蒋海萍¹,高源¹,徐农¹,俞雄飞²

¹浙江大学医学院附属第一医院肿瘤内科，杭州310000；²浙江大学医学院附属第一医院肿瘤外科，杭州310000

收稿日期:2018-12-04出版日期:2019-01-08发布日期:2019-04-03
通讯作者:徐农 E-mail:nongxu@zju.edu.cn
基金资助:

国家卫生和计划生育委员会科研基金（KWJ-ZJ-1802）；浙江省自然科学基金（LY15H160026）

Research progress of anti PD-1/PD-L1 immunotherapy biomarkers

Wang Huan¹, Jiang Haiping¹, Gao yuan¹, Xu Nong¹, Yu Xiongfei²

¹Department of Medical Oncology, First Affiliated Hospital of Zhejiang University, Hangzhou 310000, China;²Department of Surgical Oncology, First Affiliated Hospital of Zhejiang University, Hangzhou 310000, China

Received:2018-12-04Online:2019-01-08Published:2019-04-03
Contact:Xu Nong E-mail:nongxu@zju.edu.cn
Supported by:

Science Foundation of National Health and Family Planning Commission (KWJ-ZJ-1802); Natural Science Foundation of Zhejiang Province of China (LY15H160026)

摘要/Abstract

摘要：抗程序性死亡蛋白-1和程序性死亡蛋白配体-1（PD-L1）免疫检查点抑制剂已在多种实体瘤取得明显疗效，但是单药治疗有效率不高。因此，探寻合适的疗效预测标志物、精准选择潜在获益人群成为目前研究的热点。研究表明，PD-L1表达、肿瘤突变负荷、错配修复基因缺陷等可能与免疫治疗的疗效相关，对这些标志物的深入分析和探索可能为临床筛选免疫检查点抑制剂获益人群提供依据。

关键词:免疫疗法,生物学标记,PD-1,PD-L1

Abstract:Immunological checkpoint inhibitors of antiprogrammed cell death-1 and programmed cell death ligand-1 (PD-L1) have already demonstrated remarkable clinical efficacy for solid tumors, however, the effectiveness of single drug therapy in immunotherapy is not very high. Therefore, exploring the appropriate therapeutic predictive biomarkers so as to accurately identify the potential patients suitable for this therapy has become a research hotspot. Studies have shown that biomarkers such as PD-L1, tumor mutation burden and mismatch repair deficiency may be related to the efficacy of immunotherapy. Indepth analysis and exploration of these markers may provide a basis for determining those patients who are more likely to benefit from checkpoint inhibitor.

Key words:Immunotherapy,Biological markers,PD-1,PD-L1

王欢,蒋海萍,高源,徐农,俞雄飞. 抗PD-1/PD-L1免疫治疗生物标志物研究进展[J]. 国际肿瘤学杂志, 2019, 46(1): 40-44.

Wang Huan, Jiang Haiping, Gao yuan, Xu Nong, Yu Xiongfei. Research progress of anti PD-1/PD-L1 immunotherapy biomarkers[J]. Journal of International Oncology, 2019, 46(1): 40-44.

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