HOXC基因在肿瘤中的作用

摘要/Abstract

摘要：HOXC基因编码的蛋白在胚胎发育中调节多个过程，包括细胞的生长、分化、凋亡、运动和血管生成等，HOXC基因也参与人类多种实体肿瘤的发生、发展，如结直肠癌、胃癌、肝癌、乳腺癌、子宫内膜癌等，且与肿瘤的临床分期、远处转移密切相关，可作为肿瘤转移和预后判断的一个生物学预测因子。

李竟长，倪秉强. HOXC基因在肿瘤中的作用[J]. 国际肿瘤学杂志, 2019, 46(3): 181-185.

Li Jingzhang, Ni Bingqiang. Roles of HOXC gene in tumors[J]. Journal of International Oncology, 2019, 46(3): 181-185.

［1］ Bhatlekar S, Fields JZ, Boman BM. HOX genes and their role in the development of humancancers［J］. J Mol Med (Berl), 2014, 92(8): 811823. DOI: 10.1007/s001090141181y. ［2］ Vider BZ, Zimber A, Chastre E, et al. Deregulated expression of homeoboxcontaining genes, HOXB6, B8, C8, C9, and Cdx1, in human colon cancer cell lines［J］. Biochem Biophys Res Commun, 2000, 272(2): 513518. DOI: 10.1006/bbrc.2000.2804. ［3］ Luo J, Wang Z, Huang J, et al. HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription of CASP3［J］. Cancer Sci, 2018, 109(2): 317329. DOI: 10.1111/cas.13453. ［4］ Hur H, Lee JY, Yun HJ, et al. Analysis of HOX gene expression patterns in human breast cancer［J］. Mol Biotechnol, 2014, 56(1): 6471. DOI: 10.1007/s1203301396824. ［5］ Du YB, Dong B, Shen LY, et al. The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma［J］. J Surg Res, 2014, 188(2): 442450. DOI: 10.1016/j.jss.2014.01.017. ［6］ Zhang Q, Jin XS, Yang ZY, et al. Upregulated Hoxc6 expression is associated with poor survival in gastric cancer patients［J］. Neoplasma, 2013, 60(4): 439445. DOI: 10.4149/neo_2013_057. ［7］ Chen SW, Zhang Q, Xu ZF, et al. HOXC6 promotes gastric cancer cell invasion by upregulating the expression of MMP9［J］. Mol Med Rep, 2016, 14(4): 32613268. DOI: 10.3892/mmr.2016.5640. ［8］ Guo C, Hou J, Ao S, et al. HOXC10 upregulation promotes gastric cancer cell proliferation and metastasis through MAPK pathway［J］. Chin J Cancer Res, 2017, 29(6): 572580. DOI: 10.21147/j.issn.10009604. ［9］ Peng X, Kang Q, Wan R, et al. miR26a/HOXC9 dysregulation promotes metastasis and stem celllike phenotype of gastric cancer［J］. Cell Physiol Biochem, 2018, 49(4): 16591676. DOI: 10.1159/000493502. ［10］ Vider BZ, Zimber A, Hirsch D. Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression［J］. Biochem Biophys Res Commun, 1997, 232(3): 742748. DOI: 10.1006/bbrc.1997.6364. ［11］ Kasiri S, Ansari KI, Hussain I, et al. Antisense oligonucleotide mediated knockdown of HOXC13 affects cell growth and inducesapoptosis in tumor cells and over expression of HOXC13 induces 3Dcolony formation［J］. RSC Adv, 2013, 3(10): 32603269. DOI: 10.1039/C2RA22006G. ［12］ Ansari KI, Hussain I, Shrestha B, et al. HOXC6 is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment［J］. J Mol Biol, 2011, 411(2): 334349. DOI: 10.1016/j.jmb.2011.05.050. ［13］ Hussain I, Bhan A, Ansari KI, et al. BisphenolA induces expression of HOXC6, an estrogenregulated homeoboxcontaining gene associated with breast cancer［J］. Biochim Biophys Acta, 2015, 1849(6): 697708. DOI: 10.1016/j.bbagrm.2015.02.003. ［14］ Li Y, Zhang M, Chen H, et al. Ratio of miR196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis［J］. Cancer Res, 2010, 70(20): 78947904. DOI: 10.1158/00085472.CAN101675. ［15］ Li Y, Guo Z, Chen H, et al. HOXC8dependent cadherin 11 expression facilitates breast cancer cell migration through Trio and Rac［J］. Genes Cancer, 2011, 2(9): 880888. DOI: 10.1177/1947601911433129. ［16］ Ansari KI, Hussain I, Kasiri S, et al. HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4［J］. J Mol Endocrinol, 2012, 48(1): 6175. DOI: 10.1530/JME110078. ［17］ Pathiraja TN, Nayak SR, Xi Y, et al. Epigenetic reprogramming of HOXC10 in endocrineresistant breast cancer［J］. Sci Transl Med, 2014, 6(229): 229ra41. DOI: 10.1126/scitranslmed.3008326. ［18］ Sadik H, Korangath P, Nguyen N, et al. HOXC10 expression supports the development of chemotherapy resistance by fine tuning DNA repair in breast cancer cells［J］. Cancer Res, 2016, 76(15): 44434456. DOI: 10.1158/00085472.CAN160774. ［19］ Saha SS, Chowdhury RR, Mondal NR, et al. Expression signatures of HOX cluster genes in cervical cancer pathogenesis: impact of human papillomavirus type 16 oncoprotein E7［J］. Oncotarget, 2017, 8(22): 3659136602. DOI: 10.18632/oncotarget.16619. ［20］ Huang Y, Chen L, Guo A. Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer［J］. Oncol Lett, 2018, 15(5): 72917296. DOI: 10.3892/ol.2018.8200. ［21］ Eoh KJ, Kim HJ, Lee JY, et al. Upregulation of homeobox gene is correlated with poor survival outcomes in cervical cancer［J］. Oncotarget, 2017, 8(48): 8439684402. DOI: 10.18632/oncotarget.21041. ［22］ Zhai Y, Kuick R, Nan B, et al. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion［J］. Cancer Res, 2007, 67(21): 1016310172. DOI: 10.1158/00085472.CAN072056. ［23］ Lu S, Liu R, Su M, et al. Overexpression of HOXC8 is associated with poor prognosis in epithelial ovarian cancer［J］. Reprod Sci, 2016, 23(7): 944954. DOI: 10.1177/1933719115625845. ［24］ Eoh KJ, Kim HJ, Lee JY, et al. Dysregulated expression of homeobox family genes may influence survival outcomes of patients with epithelial ovarian cancer: analysis of data from The Cancer Genome Atlas［J］. Oncotarget, 2017, 8(41): 7057970585. DOI: 10.18632/oncotarget.19771. ［25］ Yamashita T, Tazawa S, Yawei Z, et al. Suppression of invasive characteristics by antisense introduction of overexpressed HOX genes in ovarian cancer cells［J］. Int J Oncol, 2006, 28(4): 931938. DOI: 10.3892/ijo.28.4.931. ［26］ Cantile M, Cindolo L, Napodano G, et al. Hyperexpression of locus C genes in the HOX network is strongly associated in vivo with human bladder transitional cell carcinomas［J］. Oncogene, 2003, 22(41): 64626468. DOI: 10.1038/sj.onc.1206808. ［27］ Lv L, Li Y, Deng H, et al. MiR193a3p promotes the multichemoresistance of bladder cancer by targeting the HOXC9 gene［J］. Cancer Lett, 2015, 357(1): 105113. DOI: 10.1016/j.canlet.2014.11.002. ［28］ Cantile M, Schiavo G, Franco R, et al. Expression of lumbosacral HOX genes, crucial in kidney organogenesis, is systematically deregulated in clear cell kidney cancers［J］. Anticancer Drugs, 2011, 22(5): 392401. DOI: 10.1097/CAD.0b013e32834505d3. ［29］ Liu YJ, Zhu Y, Yuan HX, et al. Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis［J］. Tumour Biol, 2015, 36(4): 28212829. DOI: 10.1007/s1327701429096. ［30］ Omatu T. Overexpression of human homeobox gene in lung cancer A549 cells results in enhanced motile and invasive properties［J］. Hokkaido Igaku Zasshi, 1999, 74(5): 367376. ［31］ Tang XL, Ding BX, Hua Y, et al. HOXC10 promotes the metastasis of human lung adenocarcinoma and indicates poor survival outcome［J］. Front Physiol, 2017, 8: 557. DOI: 10.3389/fphys.2017.00557. ［32］ Yao Y, Luo J, Sun Q, et al. HOXC13 promotes proliferation of lung adenocarcinoma via modulation of CCND1 and CCNE1［J］. Am J Cancer Res, 2017, 7(9): 18201834. ［33］ Liu H, Zhang M, Xu S, et al. HOXC8 promotes proliferation and migration through transcriptional upregulation of TGFβ1 in nonsmall cell lung cancer［J］. Oncogenesis, 2018, 7(2): 1. DOI: 10.1038/s4138901700164. ［34］ Guo YB, Shao YM, Chen J, et al. Effect of overexpression of HOX genes on its invasive tendency in cerebral glioma［J］. Oncol Lett, 2016, 11(1): 7580. DOI: 10.3892/ol.2015.3893. ［35］ Xuan F, Huang M, Liu W, et al. Homeobox C9 suppresses Beclin1mediated autophagy in glioblastoma by directly inhibiting the transcription of deathassociated protein kinase 1［J］. Neuro Oncol, 2016, 18(6): 819829. DOI: 10.1093/neuonc/nov281.

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Roles of HOXC gene in tumors

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