NADPH氧化酶2在恶性肿瘤中的研究进展

国际肿瘤学杂志››2023,Vol. 50››Issue (10): 618-621.doi:10.3760/cma.j.cn371439-20230428-00117

NADPH氧化酶2在恶性肿瘤中的研究进展

刘小洁¹^,², 黄俊星¹()

¹南京医科大学附属泰州人民医院/泰州市人民医院肿瘤科，泰州 225300
²大连医科大学临床医学系，大连 116000

收稿日期:2023-04-28修回日期:2023-07-28出版日期:2023-10-08发布日期:2023-11-08
通讯作者:黄俊星 E-mail:hjxtz@sina.cn
基金资助:
江苏省卫生健康委科研项目(BJ20012);江苏省医学创新团队项目(CXTDA2017042);泰州市科技支撑计划（社会发展）项目(TS202001)

Research progress of NADPH oxidase 2 in malignant tumors

Liu Xiaojie¹^,², Huang Junxing¹()

¹Department of Oncology， Affiliated Jiangsu Taizhou People's Hospital of Nanjing Medical University， Jiangsu Taizhou People's Hospital， Taizhou 225300， China
²Department of Clinical Medicine， Dalian Medical University， Dalian 116000， China

Received:2023-04-28Revised:2023-07-28Online:2023-10-08Published:2023-11-08
Contact:Huang Junxing E-mail:hjxtz@sina.cn
Supported by:
Jiangsu Commission of Health Research Project(BJ20012);Jiangsu Provincial Medical Innovation Team Project(CXTDA2017042);Taizhou Science and Technology Support Plan（Social Development）Project(TS202001)

摘要/Abstract

摘要：

还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶2（Nox2）通过产生活性氧参与及影响人体正常生理功能。目前已发现Nox2在急性髓系白血病、胃癌、结直肠癌、卵巢癌、肺癌、食管癌中与患者的预后、肿瘤抗药性、分子靶向治疗等相关，有可能是恶性肿瘤新的生物标志物及潜在的治疗靶点。

关键词:NADPH氧化酶2,肿瘤,活性氧,抗药性，肿瘤,预后

Abstract:

Reduced nicotinamide adenine dinucleotide phosphate （NADPH） oxidase 2 （Nox2） acts as a source of reactive oxygen species， which participates in and influences normal physiological function of human body. Nowadays， many studies have found that Nox2 is related to prognosis of patients， drug resistance and molecular targeted therapy in various malignant tumors， such as acute myeloid leukemia， gastric cancer， colorectal cancer， ovarian cancer， lung cancer and esophageal cancer. What's more， it may be a novel biomarker and a potential therapeutic target for malignant tumors.

Key words:NADPH oxidase 2,Neoplasms,Reactive oxygen species,Drug resistance， neoplasm,Prognosis

刘小洁, 黄俊星. NADPH氧化酶2在恶性肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(10): 618-621.

Liu Xiaojie, Huang Junxing. Research progress of NADPH oxidase 2 in malignant tumors[J]. Journal of International Oncology, 2023, 50(10): 618-621.

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