靶向肿瘤相关巨噬细胞增强结直肠癌免疫检查点抑制剂疗效的潜在策略

摘要/Abstract

摘要：

肿瘤相关巨噬细胞（TAM）在肿瘤的进展与转移中起着关键性作用，它们的特性高度依赖于肿瘤微环境（TME）的信号刺激。TAM作为肿瘤相关炎症的主要参与者，与多种实体肿瘤的预后相关。免疫检查点抑制剂（ICI）可极大地改善微卫星不稳定或错配修复缺陷结直肠癌（CRC）患者的生存预后。然而，ICI作为单一疗法在绝大多数的CRC患者中疗效受限。尽管TAM的确切功能尚未完全阐明，但以TAM为靶点的治疗策略能明显改善CRC患者的ICI疗效，TAM作为CRC预后的预测标志物也显示出重要价值。

关键词:结直肠肿瘤,肿瘤微环境,肿瘤相关巨噬细胞,免疫检查点抑制剂

Abstract:

Tumor-associated macrophage （TAM） plays a key role in tumor progression and metastasis，and their properties are highly dependent on signaling stimuli in the tumor microenvironment（TME）. Moreover，TAM，as a major player in tumor-related inflammation，is associated with the prognosis of multiple solid tumors. Immune checkpoint inhibitor （ICI） was found to significantly improve the survival prognosis of patients with microsatellite instability/mismatched repair deficient colorectal cancer. However，the efficacy of ICI as monotherapy is limited in the vast majority of CRC patients. Although the exact functions of TAM have not been fully elucidated，targeting TAM as a therapeutic strategy significantly enhances the efficacy of ICI in CRC，and TAM also demonstrates important value as predictive biomarkers for CRC prognosis.

Key words:Colorectal neoplasms,Tumor microenvironment,Tumor-associated macrophages,Immune checkpoint inhibitors

陶红, 殷红, 罗宏, 陶佳瑜. 靶向肿瘤相关巨噬细胞增强结直肠癌免疫检查点抑制剂疗效的潜在策略[J]. 国际肿瘤学杂志, 2023, 50(11): 683-687.

Tao Hong, Yin Hong, Luo Hong, Tao Jiayu. Potential strategies for targeting tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors for colorectal cancer[J]. Journal of International Oncology, 2023, 50(11): 683-687.

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