肿瘤微环境中乳酸的作用机制及相关治疗

国际肿瘤学杂志››2022,Vol. 49››Issue (6): 349-352.doi:10.3760/cma.j.cn371439-20220330-00066

肿瘤微环境中乳酸的作用机制及相关治疗

张子叔¹, 乌新林²()

¹内蒙古医科大学研究生院,呼和浩特 010050
²内蒙古医科大学附属医院胃肠外科,呼和浩特 010050

收稿日期:2022-03-30修回日期:2022-04-25出版日期:2022-06-08发布日期:2022-06-30
通讯作者:乌新林 E-mail:wuxinlin@126.
基金资助:
国家自然科学基金(81860416)

Mechanism of action of lactic acid in tumor microenvironment and related treatment

Zhang Zishu¹, Wu Xinlin²()

¹Graduate School of Inner Mongolia Medical University, Hohhot 010050, China
²Department of Gastroin-testinal Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

Received:2022-03-30Revised:2022-04-25Online:2022-06-08Published:2022-06-30
Contact:Wu Xinlin E-mail:wuxinlin@126.
Supported by:
National Natural Science Foundation of China(81860416)

摘要/Abstract

摘要：

乳酸作为肿瘤微环境中广泛存在的代谢物,主要由进行有氧糖酵解的肿瘤细胞产生。乳酸与肿瘤的发生发展密切相关,其不仅可作为底物为肿瘤细胞供能,还可作为信号分子激活多种通路从而促进肿瘤细胞的侵袭转移、血管生成以及免疫逃逸。深入研究乳酸在肿瘤发生发展中的作用机制及相关治疗进展,有利于寻找治疗肿瘤的药物作用靶点从而改善患者的预后。

关键词:肿瘤微环境,乳酸,新生血管化,病理性,肿瘤逃逸,侵袭转移

Abstract:

Lactic acid, a widespread metabolite in the tumor microenvironment, is mainly produced by tumor cells that undergo aerobic glycolysis. Lactic acid is closely related to the occurrence and development of tumor. It not only serves as a substrate to supply energy to tumor cells, but also acts as a signaling molecule to activate multiple pathways to promote invasive and metastasis, angiogenesis and immune escape of tumor cells. In-depth research on the mechanism of action of lactic acid in the occurrence and development of tumor and related therapeutic progress will help to find drug targets for treatment of tumor and improve prognosis of patients.

Key words:Tumor microenvironment,Lactic acid,Neovascularization, pathologic,Tumor escape,Invasion and metastasis

张子叔, 乌新林. 肿瘤微环境中乳酸的作用机制及相关治疗[J]. 国际肿瘤学杂志, 2022, 49(6): 349-352.

Zhang Zishu, Wu Xinlin. Mechanism of action of lactic acid in tumor microenvironment and related treatment[J]. Journal of International Oncology, 2022, 49(6): 349-352.

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