国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (2): 92-95.

• 综述 •上一篇下一篇

细胞微环境介导肿瘤P-糖蛋白的表达调控

黄帆, 李远, 彭明清

  1. 402160重庆永川区重庆医科大学附属永川医院中心实验室
  • 出版日期:2012-02-08发布日期:2012-01-18
  • 通讯作者:李远，E-mail:liyuan_1985999@163.com E-mail:liyuan_1985999@163.com
  • 基金资助:

    重庆医科大学附属永川医院院级课题（YJQN 2011027）； 重庆永川区2011年科技支撑“健康永川”专项基金（YCSTC 2011BF5001）

Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer

HUANG Fan, LI Yuan, PENG Ming-Qing

  1. Central Laboratory,YongchuanHospital,Chongqing Medical University,Chongqing402160,China
  • Online:2012-02-08Published:2012-01-18
  • Contact:Corresponding author: LI Yuan, E-mail: liyuan_1985999@163.com E-mail:liyuan_1985999@163.com

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摘要：P-糖蛋白（P-gp）表达调控与肿瘤多药耐药的发生发展密切相关。肿瘤细胞面临自身微环境内源性损伤及外源性刺激伤害，这些不利的细胞微环境触发细胞应激反应，并通过激活系列信号传导通路调控P-糖蛋白的表达。研究肿瘤细胞内源性微环境与外源性刺激损伤对P-糖蛋白的表达调控将对探寻肿瘤细胞多药耐药获得具有重要意义。

关键词:肿瘤,P糖蛋白,抗药性,信号传导

Abstract:Expression and regulation of the P-glycoprotein (P-gp)is associated withthe development of multidrug resistance in cancer. Cancer cellsare exposed inendogenous damages from its own micro-environments andinflicted stimulated damages. These harmful micro-environments could trigger cellular stress response and regulated the expression of P-gp through various activated signal transduction pathways. Researches of the cellular endogenous micro-environments and exogenous stimulation damages on the expression and regulation of P-gp would haveimportant significancefor exploring the multidrug resistance of cancer cell.

Key words:font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt,mso-bidi-font-size: 10.5pt">Neoplasms,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt,mso-bidi-font-size: 10.5pt">P-glycoprotein,Drug resistance,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt,mso-bidi-font-size: 10.5pt">Signal transduction