Abstract:Runt-related transcription factor 2(Runx2)Is a nuclear transcription factor of PEBP2/CBFsuperfamilies, and can regulate matrix metalloproteinase(MMP), osteopontin(OPN) and bone sialoprotein(BSP) which are associated with the metastasis of tumors including breast cancer and prostate cancer. In these cancers, the expression of Runx2 is highly up-regulated, which is closely correlated with the cell transformation and tumor progress . Lots of studies have demonstrated that the function of Runx2 is involved in several signal pathwaysactivation, which can promote the early metastasis of malignant tumors. Therefore，the treatment targeting to Runx2 may be a new clinically choice to blocking the metastasis of tumors in the future.

Key words:Neoplasms metastasis,Runx2