Abstract:Many researches show that the prognosis of gastrointestinal stromal tumor (GIST) are related to numerous variations of biomarkers such as numeric chromosomal aberrations or nuclear/mitochondrial microsatellite instability. In addition, the changes of proto-oncogene and tumor-suppressor gene are found to influence the prognosis of GIST. The kit and platelet-derived growth factor receptor a mutation are correlated with GIST progression, metastasis and targeted drug sensitivity, and then influence the prognosis of GIST.

Key words:Gastrointestinal stromal tumors,Biological markers,Prognosis,Molecular targeted therapy