关键词:食管癌,癌前病变,普查,早诊早治

Abstract:Objective: To study the prevalence of esophageal and precancerous lesions in high risk groups in order to provide evidence for early diagnosis and treatment.Methods: Epidemiological investigation and esophageal cancer risk assessment were conducted among 40-74 years old urban residents of Hefei. Endoscope iodine staining and indicated biopsy screening method were used for high risk of esophageal cancer people,and the pathology confirmed the diagnosis.Results: Basal cell hyperplasia detection rate was 2.95%; Low grade intraepithelial neoplasia of squamous epithelium detection rate was 0.35%; High-grade intraepithelial neoplasia of squamous epithelium detection rate was 0.09%; esophageal cancer detection rate was 0.26%. From the gender distribution, Basal cell hyperplasia of male,female detection rates were 4.18%(20/479)and 2.08%(14/672), which had a significant difference between two groups(χ²=4.27,P=0.039); male and female esophageal cancer detection rates were 0.63%(3/479) and 0.0%(0/479),with a significant difference between two groups(χ²=4.220,P=0.040). The analysis by age group showed that Basal cell hyperplasia detection rates did not have significant difference among age groups(χ²=3.409,P=0.182); Low grade intraepithelial neoplasia of squamous epithelium detection rates didn't show significant difference among age groups (χ²=3.071,P=0.215);High-grade intraepithelial neoplasia of squamous epithelium detection rates didn't show significant difference among age groups(χ²=1.816,P=0.403);esophageal cancer detection rates didn't show significant difference among age groups(χ²=0.025,P=0.992). Conclusion: There are many patients with premalignant lesions in the high risk group of esophageal cancer, and endoscopic screening and comprehensive cancer knowledge propaganda for them is the key in esophageal cancer primary prevention.

Key words:esophageal cancer,precancerous lesion,early diagnosis and treatment