Twenty-five patients with familial aggregation LAA cerebral infarction and 25 patients with sporadic LAA cerebral infarction were collected as family group and sporadic group respectively. Twenty-five healthy people were selected as the control group. Genomic DNA （gDNA） was extracted from the 75 cases， and the sequence to be tested was subjected to PCR reaction with gDNA as template. The PCR products were purified and sequenced directly to determine whether there were fibrinogen and platelet membrane glycoprotein IIb IIIa gene polymorphisms.

There was no significant difference in Fib gene polymorphism among the three groups （P> 0.05）， there was significant difference in GP IIb locus among the three groups （P< 0.05）， and there was no significant difference in Gp IIIa locus among family group， sporadic group and control group.

GP IIb gene polymorphism is abnormal in familial aggregation LAA cerebral infarction， but Fib and Gp IIIa genotypes are not abnormal.

收集家族聚集性LAA脑梗死和散发性LAA脑梗死患者各25例，分别为家族组及散发组，选择25例非心脑血管疾病患者作为对照组。75例患者均提取基因组DNA，以基因组DNA为模板对待检序列进行PCR反应，纯化PCR产物，对PCR产物直接进行测序，确定有无纤维蛋白原及血小板GP IIb/IIIa基因多态性存在。

Fib基因多态性在3组间差异无统计学意义（P> 0.05），GP IIb位点在3组之间差异有统计学意义（P< 0.05），GP Ⅲa位点在家族组、散发组、对照组3组之间差异无统计学意义（P> 0.05）。

在家族聚集性LAA脑梗死中有GP Ⅱb基因多态性异常，而Fib及GP Ⅲa基因型无异常。