Relationship between intestinal flora imbalance and severe acute pancreatitis

Abstract

Abstract:

Acute pancreatitis （AP） is one of the most clinically common acute abdominal disorders， with 10 to 20 percent progressing to severe acute pancreatitis （SAP）， which has a high mortality rate， rapid morbidity， and varied complications. There are two peaks in the death of SAP patients， the first peak occurs earlier and is associated with high mortality caused by systemic inflammatory response syndrome within two weeks of onset， and the second peak is associated with middle and late intestinal barrier damage and sepsis caused by bacterial displacement. High mortality in the middle and late stages of SAP is closely related to intestinal barrier damage and intestinal flora imbalance， and some important bacteria and its metabolites may become an important basis for diagnosis or even a target for disease treatment. Through consulting PubMed， Medline， CNKI and other databases， this paper further elaborated and summarized the relationship between intestinal flora and SAP， providing more possibilities for the treatment of SAP.

Key words:intestinal flora imbalance,severe acute pancreatitis,visceral injury

摘要：

急性胰腺炎（acute pancreatitis，AP）是临床最常见的急腹症之一，其中有10％ ~ 20％会发展为重症急性胰腺炎（severe acute pancreatitis，SAP）。SAP死亡率高、病情变化快、并发症多。SAP患者死亡存在两个高峰期，第1个高峰期发生较早，与发病2周内全身炎症反应综合征引起的高死亡率有关，第2个高峰期与中后期肠道屏障损伤，细菌易位引起的败血症有关。SAP中后期的高死亡率与肠道屏障受损、肠道菌群失衡密切相关，一些细菌及其代谢产物成为诊断疾病的重要依据，甚至是疾病治疗的靶点。本研究通过查阅PubMed、Medline和中国知网等数据库，对肠道菌群与SAP的关系进行深入的阐述和总结，为SAP的治疗提供新思路。

关键词:肠道菌群失衡,重症急性胰腺炎,脏器损伤

Cuiyu ZHU, Feifei ZHOU, Hongli YANG, Ben WANG, Hongwei XU. Relationship between intestinal flora imbalance and severe acute pancreatitis[J]. Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences, 2024, 45(7): 418-422.

朱翠宇, 周菲菲, 杨红丽, 王犇, 许洪伟. 肠道菌群失衡与重症急性胰腺炎的关系[J]. betway必威登陆网址 (betway.com )学报, 2024, 45(7): 418-422.

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