锌指蛋白与消化系统肿瘤

国际肿瘤学杂志››2020,Vol. 47››Issue (2): 115-118.doi:10.3760/cma.j.issn.1673-422X.2020.02.011

田春方, 沙丹()

betway必威登陆网址附属省立医院化疗科,济南 250021

收稿日期:2019-10-28修回日期:2019-11-18出版日期:2020-02-08发布日期:2020-05-27
通讯作者:沙丹 E-mail:shadanslyy@126.com
基金资助:
山东省自然科学基金(ZR2013HQ027)

Zinc finger proteins and digestive system cancers

Tian Chunfang, Sha Dan()

Department of Chemotherapy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China

Received:2019-10-28Revised:2019-11-18Online:2020-02-08Published:2020-05-27
Contact:Sha Dan E-mail:shadanslyy@126.com
Supported by:
Natural Science Foundation of Shandong Province of China(ZR2013HQ027)

摘要/Abstract

摘要：

锌指蛋白是人类基因组中最大的转录家族,通过促癌或抑癌作用广泛参与消化系统肿瘤的发生发展过程。研究表明多种锌指蛋白的表达异常与胃癌、肝癌、结直肠癌和胰腺癌患者的临床病理特征及预后密切相关。研究锌指蛋白的作用机制有助于为临床治疗消化系统肿瘤提供新的靶点。

关键词:胃肿瘤,癌,肝细胞,结直肠肿瘤,胰腺肿瘤,锌指蛋白

Abstract:

Zinc finger proteins (ZNFs) belong to the largest transcriptional factor family in human genome. ZNFs are widely involved in the development and progression of digestive system cancers by promoting or inhibiting carcinogenesis. Studies have shown that the abnormal expressions of various ZNFs are closely related to the clinicopathologic features and prognosis of patients with digestive system cancers, including gastric cancer, liver cancer, colorectal cancer and pancreatic cancer. Exploring the underlying mechanism of ZNFs will help to provide new targets for clinical treatment of digestive system cancers.

Key words:Stomach neoplasms,Carcinoma, hepatocellular,Colorectal neoplasms,Pancreatic neoplasms,Zinc finger proteins

田春方, 沙丹. 锌指蛋白与消化系统肿瘤[J]. 国际肿瘤学杂志, 2020, 47(2): 115-118.

Tian Chunfang, Sha Dan. Zinc finger proteins and digestive system cancers[J]. Journal of International Oncology, 2020, 47(2): 115-118.

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