国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (6): 442-445.

• 综述 •上一篇下一篇

植物多酚对胃癌的化学预防

刘入铭,姜晶,马麟,曹雪源

  1. 长春，吉林大学第一医院胃结直肠外科（刘入铭、马麟、曹雪源）,组织标本库(姜晶）
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:曹雪源，E-mail:ccmzc32jdyycao@yahoo.com.cn E-mail:ccmzc32jdyycao@yahoo.com.cn
  • 基金资助:

    国家自然科学基金资助项目（30972476、81072369）

Chemoprevention of plant polyphenols in gastric cancer

LIU Ru-ming,JIANG Jing, MA Lin, CAO Xue-yuan

  1. *Department of Gastric and Colorectal Surgery, First Clinical Hospital, Jilin University, Changchun 130021, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:CAO Xue-yuan, E-mail: ccmzc32jdyycao@yahoo.com.cn E-mail:ccmzc32jdyycao@yahoo.com.cn

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被引次数

1

摘要：胃癌的发病是多因素相互作用的过程，与宿主因素、幽门螺杆菌（Hp）感染、饮食等因素相关。植物多酚是广泛存在于植物中的一大类多酚化合物的总称，具有较强的抗氧化性，许多动物实验和临床研究表明，多酚类物质能够通过抑制Hp感染、抑制核转录因子-κB(NF-κB)表达、促进肿瘤细胞凋亡等多种途径实现对胃癌的抑制。植物多酚的应用拓宽了胃癌化学预防的途径。

关键词:胃肿瘤,植物多酚,化学预防

Abstract:Gastric cancer carcinogenesis is a multifactorial process which is related to an interaction of host factors, Helicobacter pylori (Hp) infection, dietary factors and so on. The plant polyphenols which are widely present in many plants are the general term for a large group polyphenolic compounds. They have strong antioxidant activity. Furthermore, many animal experiments and clinical studies have proved that the polyphenols could inhibit gastric cancer via inhibiting Hp infection, suppressing the expression of nuclear factor-κB (NF-κB), promoting apoptosis in cancer cells and so on. The application of plant polyphenols could broaden the approaches for chemoprevention of gastric cancer.

Key words:Stomach neoplasms,Polyphenols,Chemoprevention