MCL-1及其抑制剂在血液恶性肿瘤中的研究进展

国际肿瘤学杂志››2024,Vol. 51››Issue (2): 119-122.doi:10.3760/cma.j.cn371439-20230612-00018

MCL-1及其抑制剂在血液恶性肿瘤中的研究进展

滕远, 李莉娟(), 张连生()

兰州大学第二临床医学院，兰州 730000

收稿日期:2023-06-12修回日期:2023-12-14出版日期:2024-02-08发布日期:2024-04-03
通讯作者:张连生，Email： zhanglsh@lzu.edu.cn ；李莉娟，Email： doctorjuan@sina.com
基金资助:
国家自然科学基金(8236010019);国家血液系统疾病临床医学研究中心委托课题(2021WWA01);兰州市人才创新创业项目(2020-RC-48);兰州大学第二医院萃英科技创新项目(CY2017-ZD04);兰州大学第二医院萃英科技创新项目(CY2019-MS14)

Progress of MCL-1 and its inhibitors in hematologic malignancies

Teng Yuan, Li Lijuan(), Zhang Liansheng()

Second Clinical Medical College of Lanzhou University，Lanzhou 730000，China

Received:2023-06-12Revised:2023-12-14Online:2024-02-08Published:2024-04-03
Contact:Zhang Liansheng，Email： zhanglsh@lzu.edu.cn ；Li Lijuan，Email： doctorjuan@sina.com
Supported by:
National Natural Science Foundation of China(8236010019);Project Commissioned by the National Center for Clinical Medical Research on Hematological Diseases(2021WWA01);Lanzhou Talent Innovation and Entrepreneurship Project(2020-RC-48);Cuiying Technology Innovation Project of the Second Hospital of Lanzhou University(CY2017-ZD04);Cuiying Technology Innovation Project of the Second Hospital of Lanzhou University(CY2019-MS14)

摘要/Abstract

摘要：

髓细胞白血病1（MCL-1）是一种抗凋亡蛋白，在促进多发性骨髓瘤、急性髓系白血病和非霍奇金淋巴瘤等的细胞存活中起关键作用。MCL-1在多种血液恶性肿瘤中高表达，是导致血液恶性肿瘤患者预后不良及化疗耐药的重要因素之一，因此，MCL-1是血液恶性肿瘤的重要治疗靶点。几种MCL-1抑制剂已进入临床试验阶段，包括S63845、AZD5991、S64315、AMG-176和AMG-397。用于血液恶性肿瘤的治疗方案中既有MCL-1抑制剂单药治疗，也有与B细胞淋巴瘤2抑制剂或免疫调节药物联合治疗，均表明MCL-1抑制剂可能是血液肿瘤靶向治疗的突破口。

关键词:血液肿瘤,髓细胞白血病1,抑制剂

Abstract:

Myeloid cell leukemia-1 （MCL-1）is an anti-apoptotic protein that plays a key role in promoting cell survival in multiple myeloma，acute myeloid leukemia and non-Hodgkin lymphoma. MCL-1 is highly expressed in a variety of hematological malignancies，which is one of the important factors leading to poor prognosis and chemoresistance in patients with hematological malignancies. Therefore，MCL-1 is an important therapeutic target for hematological malignancies. Several MCL-1 inhibitors have entered clinical trials，including S63845，AZD5991，S64315，AMG-176，and AMG-397. The treatment plans used for hematological malignancies include monotherapy with MCL-1 inhibitors，as well as combination therapy with B cell lymphoma 2 inhibitors or immunomodulatory drugs，all indicating that MCL-1 inhibitors may be a breakthrough point for targeted treatment of hematological malignancies.

Key words:Hematologic neoplasms,Myeloid cell leukemia-1,Inhibitor

滕远, 李莉娟, 张连生. MCL-1及其抑制剂在血液恶性肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(2): 119-122.

Teng Yuan, Li Lijuan, Zhang Liansheng. Progress of MCL-1 and its inhibitors in hematologic malignancies[J]. Journal of International Oncology, 2024, 51(2): 119-122.

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