乙酰半胱氨酸联合布地奈德雾化吸入治疗毛细支气管炎的实效性评价

betway必威登陆网址（betway.com ）学报››2021,Vol. 42››Issue (4): 298-300.DOI:10.3969/j.issn.1004-7115.2021.04.019

乙酰半胱氨酸联合布地奈德雾化吸入治疗毛细支气管炎的实效性评价

裴艳萍¹, 米青¹, 王慧¹, 曹明燕¹, 吴桂英², 沈卉¹

1.泰安市中心医院,山东泰安 271000;
2.泰安市第一人民医院,山东泰安 271000

收稿日期:2020-11-13出版日期:2021-04-25发布日期:2021-09-01
通讯作者:沈卉,E-mail:Taishanshenhui@sina.cn。
作者简介:裴艳萍(1987—),女,山东泰安人,住院医师,硕士,主要从事临床呼吸科工作。E-mail:peiyanping1987@163.com。

Evaluation of the effectiveness of atomizing inhalation acetylcysteine and budesonide in infants with bronchiolitis

PEI Yan-ping, MI Qing, WANG Hui, CAO Ming-yan, WU Gui-ying, SHEN Hui

1. Tai'an City Central Hospital, Taian 271000, China;
2. Tai'an First People's Hospital, Taian 271000, China

Received:2020-11-13Online:2021-04-25Published:2021-09-01

摘要/Abstract

摘要：目的对儿童毛细支气管炎在常规治疗基础上给予雾化吸入乙酰半胱氨酸(Acetylcysteine,ACE)及布地奈德(Budesonide,BUD)的治疗效果进行观察及讨论,为毛细支气管炎的临床治疗提供更加优越的治疗方案。方法按照随机数字法将于2019年6月至2020年1月在泰安市中心医院住院治疗的100例儿童毛细支气管炎患儿分为两组:观察组、对照组,每组50例患儿。观察组以常规治疗为基础,在基础方案上加用ACE及BUD雾化吸入,而对照组仅给予常规治疗。将患儿的咳嗽缓解的时间、哮鸣音及湿啰音消失时间和住院的天数作为数据加以统计。因患儿年龄小,无法行肺功能检测,仅统计患儿入院时及24小时后呼吸频率(RR),最后对两组患儿疗效进行评价。结果观察组咳嗽缓解时间、哮鸣音消失时间、湿啰音消失时间和住院天数分别为(6.25±1.8)d、(2.94±1.05)d、(4.61±1.04)d和(9.19±1.8)d,对照组为(7.79±1.67)d、(4.46±1.38)d、(5.73±1.46)d和(11.42±1.91)d,两组相比,差异具有统计学意义(P＜0.05);治疗前RR差异不具有统计学意义(P＞0.05),治疗后观察组改善程度明显优于对照组(P＜0.05);观察组总有效率为96%(48/50),对照组为76%(38/50),差异具有统计学意义(P＜0.05)。结论雾化吸入ACE及BUD在缓解患儿临床表现的同时,也可以改善患儿的肺功能且疗效显著。故认为ACE联合BUD雾化吸入是毛细支气管炎安全有效的治疗方法。

关键词:乙酰半胱氨酸,布地奈德,雾化吸入,毛细支气管炎

Abstract:Objective: To observe and explore the effectiveness of atomizing inhalation acetylcysteine (ACE) and budesonide (BUD) in infants with bronchiolitis.Methods: 100 infants with bronchiolitis at our hospital from June 2012 to May 2013 were selected, and were randomly divided into two groups, with an equal number of cases in the observation group and the control group. The observation group were treated with atomizing inhalation ACE and BUD on the basis of conventional medicine treatment, while the control group were treated with conventional medicine. Cough relief time, wheeze disappearance time, crackles disappearance time and length of hospital stay in the two groups, as well respiratory rate(before treatment and 24 hours after treament) were evaluated for the efficacy of two groups.Results: Cough relief time, wheeze disappearance time, crackles disappearance time and days of hospitalization in the observation group were(6.25±1.8)d,(2.94±1.05)d,(4.61±1.04) d and(9.19±1.8)d, while was(7.79±1.67)d, (4.46±1.38)d,(5.73±1.46)d and(11.42±1.91)d in the control group, and the difference was statistically significant (P<0.05); before treatment, the difference of respiratory rate in two groups was not statistically significant (P>0.05), the degree of improvement after treatment in observation group was statistically more than that in the control group (P<0.05); the total efficiency of the observation group was 95.8%(46/48), the control group was 66.7%(32/48), and the difference was statistically significant (P<0.05).Conclusion: ACE combine with BUD inhalation therapy can significantly improve lung function in children with bronchiolitis, relieve the clinical response with a significant effect, which thus is a safe and effective treatment for bronchiolitis.

Key words:acetylcysteine,budesonide,atomizing inhalation,bronchiolitis

中图分类号:

R562

裴艳萍, 米青, 王慧, 曹明燕, 吴桂英, 沈卉. 乙酰半胱氨酸联合布地奈德雾化吸入治疗毛细支气管炎的实效性评价[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(4): 298-300.

PEI Yan-ping, MI Qing, WANG Hui, CAO Ming-yan, WU Gui-ying, SHEN Hui. Evaluation of the effectiveness of atomizing inhalation acetylcysteine and budesonide in infants with bronchiolitis[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(4): 298-300.

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