betway必威登陆网址 (betway.com )学报››2021,Vol. 42››Issue (1): 74-77.DOI:10.3969/j.issn.1004-7115.2021.01.019
张旭, 唐根富
收稿日期:
2020-09-16发布日期:
2021-09-01通讯作者:
唐根富,硕士,教授,硕士研究生导师,主要从事慢性疾病的预防与控制研究工作,E-mail: tanggenfu@163.com。作者简介:
张旭,硕士研究生,研究方向:慢性疾病的预防与控制。基金资助:
Received:
2020-09-16Published:
2021-09-01摘要:H型高血压是我国脑卒中发病率持续居高不下的重要危险因素,及时发现并干预以预防心脑血管疾病的发生是医药工作者目前的重要任务,关系到人群的健康。本文将对H型高血压的定义、流行病学特点、致病机制、危害及治疗进行综述,从而为H型高血压的预防和治疗研究提供一些参考作用。
中图分类号:
张旭, 唐根富. H型高血压的研究现状及进展[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(1): 74-77.
[1] 张明玺, 罗俊. H型高血压的病因及发病机制[J]. 心血管病学进展, 2012,33(2):253-256. [2] 李建平, 卢新政, 霍勇, 等. H型高血压诊断与治疗专家共识[J]. 中华高血压杂志, 2016,24(2):123-127. [3] 张朝当, 徐希平. H 型高血压2.0——药物研发与脑卒中精准预防[J]. 药学进展, 2019,43(8):567-575. [4] Huo Y, Li J, QIN X, et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China[J]. JAMA, 2015,313(13):1325. [5] Hu S, REN L, Wang Y, et al. Homocysteine-lowering therapy and early functional outcomes of ischemic patients with H-type hypertension: a retrospective analysis of CNSR[J]. Australasian Physical & Engineering Sciences in Medicine, 2015,38(4):785-791. [6] Jacques PF, Rosenberg IH, Rogers G, et al. Serum total homocysteine concentrations in adolescent and adult Americans: results from The Third National Health and Nutrition Examination Survey1- 4[J]. Am J Clin Nutr, 1999,69(3):482-489. [7] Hao L, Ma J, Zhu J, et al. High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status[J]. J Nutr, 2007,137(2):407-413. [8] Franco RF, Araújo AG, Guerreiro JF,et al. Analysis of the 677 C → T mutation of the methylenetetrahydrofolate reductase gene in different ethnic groups[J]. Thromb Haemost, 1998,79(1):119-121. [9] Robinson K, Arheart K, Refsum H,et al. Low circulating folate and vitamin B6 concentrations:risk factors for stroke, peripheral vascular disease, and coronary artery disease [J]. Circulation, 1998,97(5):437-443. [10] Sood HS, Hunt MJ, Tyagi SC. Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia[J]. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2003,284(2):L333-L341. [11] 王佳, 王淑玲, 曾丹, 等. 亚甲基四氢叶酸还原酶C677T基因多态性与H型高血压及同型半胱氨酸水平升高的相关性研究[J]. 中国脑血管病杂志, 2015,12(11):581-586. [12] 钱净, 施茜, 翟秀伟, 等. 昆明地区汉族H型高血压MTHFR基因C677T多态性及其相关危险因素的分析[J]. 检验医学, 2018,33(6):476-480. [13] 李蕊, 杨柳, 苏明权, 等. MTHFR基因多态性及血浆同型半胱氨酸水平与心脑血管疾病的相关性分析[J]. 检验医学, 2016,31(10):922-924. [14] 邹卓群, 仲怀琴, 李金鹆, 等. 上海市某院2015年体检人群H型高血压的患病率及其影响因素分析[J]. 安徽医学, 2017,38(11):1440-1444. [15] 吴瑕玉. 同型半胱氨酸代谢途径关键酶基因多态性及维生素B6缺乏与乳腺癌遗传易感性关系研究[D]. 昆明: 云南大学, 2013. [16] Montezano AC, Touyz RM. Reactive oxygen species, vascular noxs, and hypertension: Focus on translational and clinical research[J]. Antioxidants & Redox Signaling, 2014,20(1):164-182. [17] Young CN, Cao X, Guruju MR, et al. ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension[J]. Journal of Clinical Investigation, 2012,122(11):3960-3964. [18] Parris MK. Integrated brain restoration after ischemie stroke-medical management, risk factors, nutrients, and other interventions for managing inflammation and enhancing brain plasticity[J]. Altern Med Rev, 2009,14(01):14-35. [19] Waid DS, Morris JK, Wald NJ. Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis[J]. PloS one, 2011,6(2):e16473. [20] 华敏, 郝冬琳, 沈华超, 等. 同型半胱氨酸血症与脑卒中的关系分析[J]. 中国实用神经疾病杂志, 2013,16(22):70-71. [21] Cui R, Moriyama Y, Koike KA, et al. Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study[J]. Atherosclerosis, 2008,198(2):412-418. [22] 邵华, 高鑫, 苏汉文, 等. 血浆同型半胱氨酸与脑卒中的关系研究[J]. 卒中与神经疾病, 2011,18(4):208-209. [23] 张素荣, 陈志刚, 吕风华, 等. 冠心病和高血压血浆同型半胧氨酸及内皮素的变化[J]. 中国危重病急救医学, 2005,17(5):309. [24] 刘玉薇, 万楠. 血清同型半胱氨酸水平与冠心病相关性研究[J]. 国际检验医学杂志, 2018,39(19):2373-2375. [25] 刘小艳, 刘涛. 同型半胱氨酸及其代谢酶基因多态性与冠心病的关系[J]. 中国动脉硬化杂志, 2018,26(1):55-59. [26] 齐宏, 黄珊, 马祥生, 等. 同型半胱氨酸、高敏C反应蛋白及胱抑素C和脂蛋白相关磷脂酶A2与冠心病的相关性[J]. 广东医学, 2014,52(14):2253-2256. [27] 董少英. 冠心病心力衰竭患者的血浆同型半胱氨酸水平与QRS波时限的相关性研究[D]. 郑州: 郑州大学, 2013. [28] 林养, 陈梅, 林荣华, 等. 血清同型半胱氨酸对高血压早期肾损伤的诊断价值[J]. 海南医学院学报, 2012,18(10):1421-1422. [29] Muntner P, Hamm LL, Kusek JW, et al. The prevalence of nontraditional risk factors for coronary heart disease in patients with chronic kidney disease[J]. Annals of Internal Medicine, 2004,140(1):9. [30] 高颖. 叶酸对H型高血压同型半胱氨酸水平和主要心血管事件的影响[J]. 当代医学, 2019,25(17):102-104. [31] Bhargava S, Ali A, Bhargava EK, et al. Lowering homocysteine and modifying nutritional status with folic acid and vitamin B12 in Indian patients of vascular disease[J]. Journal of Clinical Biochemistry and Nutrition, 2012,50(3):222-226. [32] Hankey GJ. B vitamins for stroke prevention[J]. Stroke and Vascular Neurology, 2018,3(2):51-58. [33] 李建平, 霍勇, 刘平, 等. 马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效和安全性[J]. 北京大学学报:医学版, 2007,39(6):614-618. [34] 张苾薇. 依那普利叶酸片在H型轻中度原发性高血压患者治疗中的应用效果观察[J]. 中国医药指南, 2019,17(7):38-39. [35] 文海英, 赖小文, 黄楷森. 依那普利联合叶酸治疗老年H型高血压病对患者炎性因子及血管内皮功能的影响[J]. 临床误诊误治, 2019,32(2):22-26. [36] 阴其云. 依那普利联用叶酸治疗H型高血压的临床疗效及对血管内皮功能的影响分析[J]. 中国实用医药, 2019,14(2):11-13. [37] 王喆, 宋德明, 郑元喜, 等. 苯磺酸氨氯地平叶酸片治疗H型高血压疗效观察[J]. 安徽医药, 2017,21(7):1290-1294. [38] Wang X, Qin X, DEMIRTAS H, et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis[J]. Lancet, 2007,369(9576):1876-1882. [39] Huo Y, Li J, Qin X, et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China[J]. JAMA, 2015,313(13):1325. [40] Wang W, Wang X, Zhang Z, et al. A Meta-analysis of folic acid in combination with anti-hypertension drugs in patients with hypertension and hyperhomocysteinemia[J]. Frontiers in Pharmacology, 2017,8:585. [41] Xu X, Qin X, Li Y, et al. Efficacy of folic acid therapy on the progression of chronic kidney disease[J]. JAMA Internal Medicine, 2016,176(10):1443. [42] Li Y, Qin X, Luo L, et al. Folic acid therapy reduces the risk of mortality associated with heavy proteinuria among hypertensive patients[J]. Journal of Hypertension, 2017,35(6):1302-1309. |
[1] | 江雪, 刘伯言, 吴逢霖, 薛雅卓, 秦树存.氢分子应用于疾病治疗的临床研究进展[J]. betway必威登陆网址 (betway.com )学报, 2023, 44(7): 552-560. |
[2] | 司贵米, 山长平.外泌体非编码RNA在三阴性乳腺癌中的研究进展[J]. betway必威登陆网址 (betway.com )学报, 2023, 44(6): 461-465. |
[3] | 陈然, 高翔, 张树才, 马丽.高级别脑胶质瘤的内科治疗研究现状及进展[J]. betway必威登陆网址 (betway.com )学报, 2023, 44(6): 444-451. |
[4] | 萨日那, 梁鲁, 姚碧辉, 黄原.急性胰腺炎临床评分系统的研究进展[J]. betway必威登陆网址 (betway.com )学报, 2023, 44(2): 156-160. |
[5] | 胡旭晨, 郑冠鹏, 陶慧, 刘天佑.经肛门内镜微创手术的应用现状和进展[J]. betway必威登陆网址 (betway.com )学报, 2022, 43(12): 948-953. |
[6] | 孙菲菲, 李军, 胡传芬, 张伯全, 王爱青, 王芳, 赵海英.抑郁症患者舞动治疗体验的质性研究[J]. betway必威登陆网址 (betway.com )学报, 2022, 43(11): 829-833. |
[7] | 于新祥, 李琳琳, 彭宁宁, 王玮琳, 李炳龙, 齐永秀.四联疗法根除幽门螺杆菌的研究进展[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(8): 638-640. |
[8] | 王欢欢.细辛脑注射液、布地奈德联合异丙托溴铵吸入治疗成人哮喘的疗效[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(8): 621-624. |
[9] | 马福静.盐酸替罗非班治疗进展性脑卒中和短暂性脑缺血发作的临床疗效[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(6): 457-459. |
[10] | 赵敏, 秦树存.氢气生物医学效应的发现、研究与应用[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(5): 339-346. |
[11] | 刘洁, 李炫宗, 于金明.2020年度肺癌放射治疗领域研究进展[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(5): 321-326. |
[12] | 金晨, 李矿.青少年特发性脊柱侧凸的支具治疗进展[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(2): 157-160. |
[13] | 杨文燕, 甄天民, 吴敏, 宋奎勐, 张晶晶, 颜建华, 孙娜, 孔春燕.护士对“互联网+护理服务”认知的调查分析[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(2): 85-88. |
[14] | 崔敏, 马颖, 王丽, 丁宏, 谢思琦.安徽省按病种付费政策的利益相关者分析[J]. betway必威登陆网址 (betway.com )学报, 2021, 42(1): 17-20. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||