Abstract:Objective: To analyze serum 25-(OH)D and to explore the relationship between 25-(OH)D and bone mineral density(BMD) in type 2 diabetic nephropathy. Methods: Sixty type 2 diabetic patients with nephropathy (24 h urinary protein＞30 mg,GFR≥45)were selected. According to BMD values,subjects were divided into normal bone mass group and abnormal bone mass group(including low bone mass and osteoporosis). Serum 25-(OH)D were detected to analyze its relationship with BMD. Results: 25-(OH)D levels were decreased significantly in abnormal bone mass group, and positively correlated with BMD values(P＜0.05). Conclusion: Decrease of BMD and osteoporosis in type 2 diabetic nephropathy is associated with the decrease of 25-(OH)D.

Key words:diabetic nephropathy,25-hydroxy vitamin D,bone mineral density

摘要：目的 检测2型糖尿病肾病患者血清25-羟维生素D[25-hydroxy vitamin D,25-(OH)D]水平的变化,分析其与骨密度(bone mineral Density,BMD)的相关性。方法 选择60例2型糖尿病肾病患者,24 h尿蛋白大于30 mg,肾功能分期在1~3a期(GFR≥45),并采用双能X线骨密度仪检测所有患者腰椎及髋部骨密度,依据骨密度分为骨量正常组和骨量异常组(包括低骨量和骨质疏松患者),电化学发光法检测血清25-羟维生素D水平,进行相关性分析。结果 2型糖尿病肾病患者血清25-羟维生素D与腰椎骨密度及左髋骨密度呈正相关(P＜0.05)。结论 2型糖尿病肾病患者骨密度的下降及骨质疏松的发生与25-羟维生素D水平下降密切相关。

关键词:糖尿病肾病,25-羟维生素D,骨密度