Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences››2022,Vol. 43››Issue (1): 53-55.DOI:10.3969/j.issn.2097-0005.2022.01.014

• Clinical Researches •Previous ArticlesNext Articles

Effectiveness and safety of carbamazepine combined with low dose topiramate in the treatment of children with epilepsy

Junfeng WANG()

  1. Department of Pediatrics,Juye County People's Hospital,Juye 274900,China
  • Received:2021-07-19Online:2022-01-25Published:2022-02-23

小剂量托吡酯联合卡马西平治疗小儿癫痫的临床疗效及安全性

王君峰()

  1. 巨野县人民医院儿科,山东 菏泽 274900
  • 作者简介:王君峰,本科,主治医师,主要从事临床儿内科工作,E-mail:hzjyhbhpk@163.com

Abstract: Objective

To investigate the clinical efficacy and safety of carbamazepine combined with low-dose topiramate in children with epilepsy.

Methods

From January 2018 to March 2020, 96 cases of children with epilepsy were selected. According to random number table method, they were divided into control group (n= 48) and experimental group (n= 48). The control group was treated with conventional dose of topiramate and the experimental group was treated with carbamazepine combined with low-dose topiramate. The changes of ALP, SC, total effective rate, adverse reaction rate and treatment were compared between the two groups.

Results

The ALP and SC levels of the two groups after treatment were significantly better than those of the control group (P< 0.05), with statistical value; However, there was no significant difference between the two before treatment (P> 0.05). Comparison of total response rate, adverse reaction rate, treatment and length of stay between the two groups showed that the experimental group was significantly better than the control group (P< 0.05), with statistical value.

Conclusion

Carbamazepine combined with low-dose topiramate has a definite effect on the treatment of epilepsy in children, that is, it has little effect on bone metabolism, can effectively improve the symptoms of epilepsy, shorten the curative effect and have fewer adverse reactions, and is beneficial to the recovery of the disease in children, which is worthy of promotion and research.

Key words:pediatric epilepsy,kamasipin,low dose topiramate,clinical efficacy,security

摘要: 目的

探讨小剂量托吡酯联合卡马西平治疗小儿癫痫的临床疗效及安全性。

方法

选取2018年1月—2020年3月在巨野县人民医院就诊的癫痫患儿96例,按照随机数字表法分为对照组和试验组,每组各48例。对照组采用托吡酯常规剂量治疗,试验组采用卡马西平联合小剂量托吡酯治疗。比较两组血碱性磷酸酶(alkaline phosphatase,ALP)、血钙(serum calcium,SC)等水平变化,总有效率、不良反应率及治疗情况。

结果

治疗后试验组ALP、SC水平优于对照组,差异有统计学意义(P< 0.05);试验组总有效率、不良反应率、治疗及住院时间优于对照组,差异有统计学意义(P< 0.05)。

结论

卡马西平联合小剂量托吡酯治疗小儿癫痫的疗效确切,对骨代谢影响小,可有效改善癫痫症状,缩短疗效,且不良反应少,利于患儿病情恢复,值得临床推广。

关键词:小儿癫痫,卡马西平,小剂量托吡酯,临床疗效,安全性