Research progress between pyroptosis and adverse pregnancy outcomes

Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences››2023,Vol. 44››Issue (1): 10-14.DOI:10.3969/j.issn.2097-0005.2023.01.002

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Research progress between pyroptosis and adverse pregnancy outcomes

Jin WEN(), Ning LI, Zihui LI, Zhiying MA, Haiting MAO

Department of Clinical Laboratory，the Second Hospital of Shandong University，Jinan250033，China

Received:2022-11-01Online:2023-01-25Published:2023-03-31
Contact:Haiting MAO

细胞焦亡与不良妊娠结局关系研究进展

温金(), 李宁, 李梓汇, 马智颖, 毛海婷

山东大学第二医院检验医学中心，山东济南 250033

通讯作者:毛海婷
作者简介:温金，硕士研究生，研究方向：生殖免疫，E-mail：202035966@mail.sdu.edu.cn。
毛海婷，医学博士，教授，博士生导师，山东大学第二医院检验医学中心主任。山东省青年科技奖获得者，山东省卫生系统中青年重点科技人才。中华检验医学教育学院山东分院院长，中国医检整合联盟常务理事，中华医学会检验医学分会免疫学组委员，中国医药教育协会医学基因组学与生物信息学专业委员会副主任委员，中国中西医结合学会检验医学专业委员会肿瘤免疫实验诊断专家委员会副主任委员，山东免疫学会免疫诊断技术专业委员会主委，山东省医学会检验医学分会副主任委员，山东省医学会微生物与免疫学分会副主任委员，山东省医院协会临床检验专业委员会副主任委员，山东省抗癌协会肿瘤实验诊断分会副主任委员、山东省研究型医院协会检验医学专业委员会副主委、山东免疫学会常务理事及基础免疫专业委员会副主任委员等。从事检验医学和基础医学研究30年，主要专业方向为免疫耐受微环境中耐受机制的研究。分别在美国、瑞典和澳大利亚访问研究。先后主持国家自然科学基金面上项目等课题20多项。在Nature Communications （IF = 17.7）等SCI杂志发表相关研究论文50多篇。获山东省科技进步二等奖5项，山东省科技进步三等奖2项，山东省医学科技奖二等奖1项。以首位发明人获国家发明专利11项。作为主编及副主编分别编写人民卫生出版社学术专著3部：《胃癌》《肝癌》《肿瘤分子靶向治疗学》。为《中华肿瘤防治杂志》编委，《betway必威登陆网址（betway.com ）学报》编委，《江苏大学学报（医学版）》编委、Cancer Letters、Journal of Experimental & Clinical Cancer Research、《临床肝胆病杂志》《山东大学学报（医学版）》审稿专家。 E-mail：maohaiting@sdu.edu.cn。
基金资助:
国家自然科学基金(82172342);山东省自然科学基金(ZR2019MC064)

Abstract

Abstract:

Pyroptosis is a pattern of programmed cell death mediated by the GSDMD family and is characterized by plasma membrane swelling and sparing and release of inflammatory mediators. It has been found that pyroptosis is closely associated with adverse pregnancy outcomes， causing a decrease in trophoblast invasive function， superficial invasion of the maternal meconium， impaired remodeling of the uterine spiral arteries， induction of oxidative stress， release of large amounts of inflammatory factors， induction of immune cell aggregation， and inflammatory damage， which in turn leads to the development of adverse pregnancy outcomes， such as recurrent miscarriage， preeclampsia， gestational diabetes and preterm delivery.

Key words:pyroptosis,pregnancy,recurrent miscarriage,preeclampsia,gestational diabetes,preterm delivery

摘要：

细胞焦亡是一种由Gasdermin（GSDMD）蛋白家族介导的程序性细胞死亡模式，其特征为细胞肿胀、疏松及炎性介质释放。研究发现，滋养细胞层焦亡与不良妊娠结局有密切联系，会使滋养层细胞侵袭功能下降，侵入母体蜕膜过浅，子宫螺旋动脉重塑障碍，诱发氧化应激反应，释放大量炎症因子，诱导免疫细胞聚集，产生炎性损伤，进而导致复发性流产、子痫前期、妊娠期糖尿病、早产等不良妊娠结局。本文就细胞焦亡在不良妊娠结局中的研究进展进行综述。

关键词:细胞焦亡,妊娠,复发性流产,子痫前期,妊娠期糖尿病,早产

Jin WEN, Ning LI, Zihui LI, Zhiying MA, Haiting MAO. Research progress between pyroptosis and adverse pregnancy outcomes[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2023, 44(1): 10-14.

温金, 李宁, 李梓汇, 马智颖, 毛海婷. 细胞焦亡与不良妊娠结局关系研究进展[J]. betway必威登陆网址（betway.com ）学报, 2023, 44(1): 10-14.

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