The relationship of pyroptosis with autophagy and its role in pathogenesis and development of atherosclerosis

Abstract

Abstract:

Pyroptosis is different from other types of cell death in morphologically and mechanistically， and it is a type of cell death that relies on the inflammasome. Activated caspase-1 can induce pyroptosis， and cells secrete pro-inflammatory cytokines IL-1β and IL-18， which are widely involved in the progression of various chronic diseases， such as atherosclerosis and type 2 diabetes. Some studies have shown that defects in autophagy can stimulate pyroptosis and accelerate the process of atherosclerosis. This article summarizes the research progress of pyroptosis and its role in the development of atherosclerosis in recent years， and discusses whether the relationship between pyroptosis and autophagy can be used as a new target for the prevention and treatment of atherosclerosis.

Key words:pyroptosis,inflammasome,autophagy,atherosclerosis

摘要：

细胞焦亡（pyroptosis）是一种程序性的死亡方式，活化的天冬半胱氨酸酶-1（caspase-1）可以诱导焦亡的发生，并促进炎症因子IL-1β和IL-18等的释放，且焦亡广泛参与各种慢性疾病的进展，如动脉粥样硬化（atherosclerosis， AS）、2型糖尿病等。有研究表明，自噬的缺陷会刺激细胞焦亡，且会加快AS的进程。本文总结了近几年来有关细胞焦亡及其在AS发展中的作用研究进展，并探讨了细胞焦亡与自噬的相互关系是否可作为防治AS的新靶点。

关键词:细胞焦亡,炎症小体,自噬,动脉粥样硬化

Tianqi PAN, Hua TIAN, Shutong YAO. The relationship of pyroptosis with autophagy and its role in pathogenesis and development of atherosclerosis[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2022, 43(2): 156-160.

潘天琦, 田华, 姚树桐. 细胞焦亡与自噬的相互关系及其在动脉粥样硬化发生发展中的作用[J]. betway必威登陆网址（betway.com ）学报, 2022, 43(2): 156-160.

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