A new target for immunotherapy of lung cancer： neutrophil extracellular trapping networks

Abstract

Abstract:

Lung cancer is one of the malignant tumors with high morbidity and mortality in China. Therefore， it is particularly important to understand the mechanisms of its occurrence and development in order to adopt better strategies for prevention and treatment. The tumor-associated microenvironment plays an important role in the development of tumors，and tumor-associated neutrophils represent most inflammatory cells in the tumor microenvironment. Neutrophil extracellular trapping networks （NETs） is a network structure secreted by neutrophils. However， the mechanism which NETs promote the occurrence and development of lung cancer remains unclear， and this review focuses on the important role which plays in the development of lung cancer.

Key words:lung cancer,neutrophil extracellular trapping networks,neutrophil,inflammation

摘要：

肺癌是我国居民发病率和死亡率都较高的恶性肿瘤之一，了解其发生和发展的机制以便采取更好的策略进行预防和治疗尤为重要。肿瘤相关微环境在肿瘤的发生、发展中起着重要作用，肿瘤相关的中性粒细胞代表着肿瘤微环境中的大部分炎性细胞，中性粒细胞能够分泌一种网状结构称为中性粒细胞胞外诱捕网（neutrophil extracellular trapping networks，NETs），然而，NETs促进肿瘤发生、发展的相关机制尚不清楚，本综述着重讨论了其在肺癌发生、发展中所起的关键作用。

关键词:肺癌,中性粒细胞胞外诱捕网,中性粒细胞,炎症

Hongzhen ZHAO, Lingxin KONG, Zengming WANG, Bin ZHAO, Guochen DUAN. A new target for immunotherapy of lung cancer： neutrophil extracellular trapping networks[J]. Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences, 2024, 45(7): 433-437.

赵洪珍, 孔令欣, 汪增明, 赵斌, 段国辰. 肺癌免疫治疗新靶点：中性粒细胞胞外诱捕网[J]. betway必威登陆网址 (betway.com )学报, 2024, 45(7): 433-437.

Figures/Tables1

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