国际肿瘤学杂志››2013,Vol. 40››Issue (12): 924-926.doi:10.3760/cma.j.issn.1673-422X.2013.12.014

• 综述 •上一篇下一篇

上皮-间质转化与胃癌

刘利敏, 李继坤

  1. 200080 上海交通大学附属第一人民医院普外科
  • 出版日期:2013-12-10发布日期:2013-12-26
  • 通讯作者:李继坤 E-mail:jkli65975@163.com

Epithelial-mesenchymal transition and gastric cancer

LIU Li-Min, LI Ji-Kun

  1. Department of General Surgery, Affiliated First People′s Hospital of Shanghai Jiao Tong University, Shanghai 200080, China
  • Online:2013-12-10Published:2013-12-26
  • Contact:LI Ji-Kun E-mail:jkli65975@163.com

摘要:上皮间质转化(EMT)是上皮细胞向间质细胞转化的现象。近年来发现EMT可以通过多种机制影响胃癌的发生发展,促进肿瘤细胞迁移和侵袭。EMT的发生涉及多个信号通路,与微小RNA、幽门螺杆菌、转录因子等有关,其有望成为治疗侵袭性胃癌的新靶点。

关键词:胃肿瘤,信号传导,肿瘤转移,上皮-间质转化

Abstract:Epithelialmesenchymal transition (EMT) is that cells undergo a switch from epithelial phenotype to mesenchymal phenotype. Recent researches show that EMT can affect the occurrence and development of gastric cancer through a variety of mechanisms and promote the migration and invasion of tumor cells. The process of EMT involves a number of signal transduction pathways, and is related to microRNAs, Helicobacter pylori, transcription factors and so on. EMT is expected to be a novel therapeutic target of gastric cancer.

Key words:Stomach neoplasms,Signal transduction,Neoplasm metastasis,Epithelial-mesenchymal transition