Table of Content

25 January 2021, Volume 42 Issue 1

Next Issue

For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

Select

Extraction and selection of tumor blood vessels in DSA images of liver

WANG Li, MENG Qing-min, GUO Yong-xin, JIAO Qing

2021, 42(1): 1-5. DOI: 10.3969/j.issn.1004-7115.2021.01.001

Asbtract( ) PDF(1535KB) ( )

References| Related Articles| Metrics

Objective: To obtain the blood supply vessels of the liver tumor through processing the digital subtraction angiography (DSA) image, and to provide the clinical treatment basis for the detection of tumor interventional therapy and embolization. Methods: The tumor images, the blood vessels and liver vessels were obtained before and after being processed on the MATLAB platform . Results: The extraction of liver tumor, blood supply vessel of liver tumor and blood vessel of liver were realized. Conclusion: For randomly selected DSA images, this method can obtain ideal liver blood vessels and blood vessels for liver tumors, which can provide basis for the treatment of clinicians, and serve for scientific research and teaching.

Select

Effect of rutinside on memory impairment induced by scopolamine in mice

LU Xiao-ming, RUAN Shu-meng, SONG Zeng-mei, CHEN Mei-hua

2021, 42(1): 6-9. DOI: 10.3969/j.issn.1004-7115.2021.01.002

Asbtract( ) PDF(1274KB) ( )

References| Related Articles| Metrics

Objective: To observe the effect of rutinside on scopolamine induced memory impairment in mice. Methods: The mice were randomly divided into normal group, model group, rutin high, medium and low dose group. The mice in treatment groups were given Rutin in different doses once a day for 14 days. The spatial position memory ability of mice were tested by Morris maze. Scopolamine of 1 mg/kg was injected intraperitoneally 30 minutes before the behavioral experiment.SOD activity, MDA content and AChE activity in brain tissue were measured. HE staining was used to observe pathological changes in brain. Results: Rutinside prolonged the escape latency, increased the swimming time and distance in the target quadrant in Morris maze ( P<0.05). Compared with the model group, rutinside could increase SOD activity, decrease MDA content and AchE activity in brain tissue in mice ( P<0.05).Conclusion: Rutin can improve the learning and memory ability, reduce AChE activity and make protective effect on memory impairment induced by scopolamine.

Select

Analysis of esophageal cancer and precancerous lesions in high-risk groups of esophageal cancer

ZHANG Juan, WEI Dong-hua, YIN Hui-ping, MA Yan-ling

2021, 42(1): 10-12. DOI: 10.3969/j.issn.1004-7115.2021.01.003

Asbtract( ) PDF(1160KB) ( )

References| Related Articles| Metrics

Objective: To study the prevalence of esophageal and precancerous lesions in high risk groups in order to provide evidence for early diagnosis and treatment.Methods: Epidemiological investigation and esophageal cancer risk assessment were conducted among 40-74 years old urban residents of Hefei. Endoscope iodine staining and indicated biopsy screening method were used for high risk of esophageal cancer people,and the pathology confirmed the diagnosis.Results: Basal cell hyperplasia detection rate was 2.95%; Low grade intraepithelial neoplasia of squamous epithelium detection rate was 0.35%; High-grade intraepithelial neoplasia of squamous epithelium detection rate was 0.09%; esophageal cancer detection rate was 0.26%. From the gender distribution, Basal cell hyperplasia of male,female detection rates were 4.18%(20/479)and 2.08%(14/672), which had a significant difference between two groups( χ²=4.27,P=0.039); male and female esophageal cancer detection rates were 0.63%(3/479) and 0.0%(0/479),with a significant difference between two groups( χ²=4.220,P=0.040). The analysis by age group showed that Basal cell hyperplasia detection rates did not have significant difference among age groups( χ²=3.409,P=0.182); Low grade intraepithelial neoplasia of squamous epithelium detection rates didn't show significant difference among age groups ( χ²=3.071,P=0.215);High-grade intraepithelial neoplasia of squamous epithelium detection rates didn't show significant difference among age groups( χ²=1.816,P=0.403);esophageal cancer detection rates didn't show significant difference among age groups( χ²=0.025,P=0.992). Conclusion: There are many patients with premalignant lesions in the high risk group of esophageal cancer, and endoscopic screening and comprehensive cancer knowledge propaganda for them is the key in esophageal cancer primary prevention.

Select

Epidemiological characteristics of category A and B infectious diseases in China from 2008 to 2018

LI Qin-lin, LIU Xue-na

2021, 42(1): 13-16. DOI: 10.3969/j.issn.1004-7115.2021.01.004

Asbtract( ) PDF(1207KB) ( )

References| Related Articles| Metrics

Objective: To understand the epidemiological characteristics and incidence trends of category A and B infectious diseases in China, and to provide supporting material specially for formulating preventive measures of these diseases. Methods: The epidemiological characteristics of category A and B infectious diseases in China from 2008 to 2018 were analyzed by descriptive epidemiological methods. Results: The incidence rate of category A and B infectious diseases showed a decline in the past 2008-2018 years. The mortality showed a significant upward. The incidence rates of viral hepatitis and tuberculosis in 2008-2018 were ranked the top two in the past 11 years, which was significantly higher than other types of infectious diseases; the incidence rates of four infectious diseases with various route of transmission (from high to low) were: blood transmission and sexually transmitted diseases, respiratory infectious diseases, intestinal infectious diseases and natural focus and insect borne infectious diseases. Conclusions: At present, incidence rates of some category A and B infectious diseases in China increase, so does the mortality. What's more, the emerging infectious diseases should be controlled efficiently by relevant departments as a major public health problem in China.

Select

Analysis on diseases related to groups among stakeholders in Anhui

CUI Min, MA Ying, WANG Li, DING Hong, XIE Si-qi

2021, 42(1): 17-20. DOI: 10.3969/j.issn.1004-7115.2021.01.005

Asbtract( ) PDF(1243KB) ( )

References| Related Articles| Metrics

Objective: To analyze the interest demands of each stakeholders in diseases related to groups policy in Anhui and the influence of their interests so as to provide the basis for further improving diseases related to groups policy in Anhui. Methods: Questionnaire survey was used to collect data, Mitchell scoring method and stakeholder impact index were adopted to identify four major stakeholders, and stakeholder theory was used for analysis. Results: The health care commission (SII=0.622, first) and the medical insurance regulatory agency (SII=0.569, second) were decisive stakeholders.Medical institutions (SII=0.201, fifth) were dependent stakeholders. Medical personnel (SII=0.071, ninth) were free to treat stakeholders. Patients (SII=0.039,11th) were critical stakeholders. Conclusion: Health commission/medical insurance management agencies, medical institutions, medical personnel and patients are the core stakeholders of diseases related to groups policy.

Select

The status and influencing factors of alexithymia of higher vocational college students with left-behind experience

YU Hui

2021, 42(1): 21-26. DOI: 10.3969/j.issn.1004-7115.2021.01.006

Asbtract( ) PDF(1251KB) ( )

References| Related Articles| Metrics

Objective: To understand the status of alexithymia of higher vocational students with left-behind experience and to explore its influencing factors. Methods: A stratified cluster random sampling method was used to select 654 left behind vocational college students in a vocational college in Anhui Province as the research objects. They were investigated by left behind basic situation questionnaire, Toronto Alexithymia Scale (TAS-20), Self-rating Questionnaire for Adolescent Problematic Mobile Phone Use (SQAPMPU) and Social Support Rate Scale (SSRS). Results: The incidence of alexithymia was 28.1% in 654 left-behind vocational college students, with a total score of 59.80±12.23. The scores of the three dimensions from high to low were: extroversive thinking, emotional description and emotional discrimination. Multiple linear regression analysis showed that gender, family type, self-evaluation parenting style, parent-child separation age, whether to participate in physical activity or not and whether to have mobile phone use dependence or not had an impact on alexithymia of higher vocational college students with left-behind experience ( P<0.01). Conclusion: The level of alexithymia of the students with left-behind experience, especially that of the extroversive thinking is relatively high. Effective intervention should be carried out according to the relevant influencing factors to reduce the level of alexithymia of the students with left-behind experience.

Select

The present situation and influencing factors of the social health of the elderly in communities in Anhui Province

YANG Yu-cheng, HONG Qian, ZHOU Wei-qiang, ZHOU Rong-jun, DENG Yu-chen, DUAN Shu-pei, WANG Yan-hong

2021, 42(1): 27-30. DOI: 10.3969/j.issn.1004-7115.2021.01.007

Asbtract( ) PDF(1168KB) ( )

References| Related Articles| Metrics

Objective: To understand the social health status and influencing factors of community-based elderly people in communities in Anhui Province, and to provide new ideas for promoting the development of community-based elderly care services and improving the health of elderly groups. Methods: Combined with the self-made questionnaire of the self-tested health assessment scale, the self-administered questionnaire of the social health sub-scale was used to conduct a face-to-face survey on randomly selected community-dwelling elderly persons aged 65 and over in Hefei and Fuyang, Anhui Province. Results: A total of 500 elderly people were effectively investigated. The overall social health score of the elderly living in communities in Anhui Province was (84.79±11.24), of which the score of "role activity and social adaptation" was the highest, (92.63±9.84), and the score of "social resources and social contact" was the lowest. It is (76.80±16.13) points. Multiple linear regression analysis showed that age, marital status, source of income, and type of payment for medical expenses were related to the social health score of the elderly ( P<0.05). The urban employees' medical insurance had a higher social health score. Conclusion: The social health of the elderly at home in communities in Anhui Province is good. The community should strengthen health education for the elderly, focusing on the elderly, the aged without a spouse and the widowed seniors, improve the economic independence of the elderly, and maintain a certain medical expenditure is beneficial to the social health of the elderly.

Select

Analysis of prognostic factors of perinatal cardiomyopathy

QI Xi-mei, DU Yang, ZHANG Ping-ping, WANG Dong-mei, DU Bo

2021, 42(1): 31-36. DOI: 10.3969/j.issn.1004-7115.2021.01.008

Asbtract( ) PDF(1199KB) ( )

References| Related Articles| Metrics

Objective: To determine predictors and indicators of clinical outcomes of patients with peripartum cardiomyopathy (PPCM).Methods: The retrospective study was conducted from January 2008 to May 2019 at our Hospital. Forty-four cases were collected and followed up for 1-114 months. Recovery was defined as a left ventricular end diastolic diameter (LVEDD) of no more than 50 mm and a left ventricular ejection fraction(LVEF) of no less than 50% . Persistent left ventricular dysfunction was defined as a LVEDD of more than 50mm and LVEF of less than 50% at the end of follow-up.The clinical characteristics, treatment protocols and outcomes of the patients were compared.Results: In this study, the estimated incidence of PPCM was approximately 1/1 710,44 cases were collected and followed up for 1-114 months. 34 of all the patients completed the follow-up.23 (68%) cases recovered and 11(32%) did not. The average age of 23 (68%) was (30.6±7.2) years old. Their body mass index (BMI) was (29.0±2.1)kg/m ². The LVEF at diagnosis was (40.02±9.2)%, and the LVEDD was (58.0±6.5)mm. The average age of 11 (32%) was (34.2±5.6) years old. Their body mass index (BMI) was (35.6±1.9)kg/m ². The LVEF at diagnosis was (30.9±10.2)%, and the LVEDD was (65.0±6.3)mm. (2) There was no significant difference in the past history, age, onset time, blood pressure, heart rate, hemoglobin, glucose, C reactive protein (CRP), thyroid stimulating hormone(TSH), creatine kinase (CK), creatine kinase isoenzymes (CKMB), NT-proBNP uric acid, pulmonary aterial systolic pressure (PASP) and the percentage of patients taking ACEI or ARB, β-blockers and Digoxin between the two groups ( P>0.05). Compared with the control group,the recovery group had lower BMI( t=8.940,P＜0.001),lesser parities( P＜0.001), lesser number of fetus( P＜0.001),higher cardiac troponins( Z=2.024,P=0.043), lesser proteinuria ( P=0.002), smaller left ventricular ( t=2.965,P=0.006),. higher left ventricular ejection fraction( t=2.633,P=0.012), lesser severity of mitral regurgitation( P＜0.001)and pleural effusions( P＜0.001)and higher bromocriptine( P＜0.001).Conclusion: High body mass index, multiparity, multiple pregnancy, left ventricular end diastolic diameter left ventricular ejection fraction severity of mitral regurgitation and the use of beta blockers or bromocriptine are all indicators of prognosis of patients with PPCM, among which left ventricular end diastolic diameter of being more than or equal to 63mm indicates poor prognosis.

Select

Oxaliplatin combined with fluorouracil/calcium folinate regimen in the treatment of advanced hepatocellular carcinoma through hepatic artery infusion chemotherapy

LI Wei, ZHANG Liang-jie, LI Dong-dong, ZHAO Shou-song

2021, 42(1): 37-40. DOI: 10.3969/j.issn.1004-7115.2021.01.009

Asbtract( ) PDF(1221KB) ( )

References| Related Articles| Metrics

Objective: To explore the clinical efficacy of FOLFOX regimen via hepatic artery infusion chemotherapy in the treatment of advanced primary hepatocellular carcinoma. Methods: Forty patients with advanced primary liver cancer were divided into two groups: experimental group and control group. The experimental group received at least one course of hepatic artery infusion chemotherapy (FOLFOX program), while the control group received routine intravenous chemotherapy (FOLFOX program), and the therapeutic effect was evaluated. Results: The tumor size of all patients in the experimental group was reduced in different degrees, and the complete and partial remission rates were improved in different degrees. The median follow-up time of the control group was 8.5 months (2.2-11.8 months), the median disease progression free survival(PFS) time was 8.7 months (95% CI:6.3-10.3 months), overall survival rate (OS) was 9.8 months (95% CI:8.3-10.1 months), and the cumulative 1-year survival rate was 60%. The median follow-up time of patients was 8.9 months (2.3-12.9 months), PFS was 9.5 months (95% CI:6.5-10.8 months), and OS was 10.9 months (95% CI:8.6-11.5 months). The cumulative 1-year survival rate was 80%. Conclusion: The FOLFOX regimen for patients with advanced liver cancer through hepatic arterial infusion chemotherapy is a more efficient treatment method and is worthy of further clinical promotion.

Select

Study on the changes of procalcitonin, C reactive protein and ESR in non-infected patients after spinal surgery

HAN Jian-long, ZHU Xin-wei, QIU Si-qiang, ZHU Deng-song, LUAN Fang-hai, CHANG Gang, LV Xiao-ye, ZUO Jin-liang

2021, 42(1): 41-45. DOI: 10.3969/j.issn.1004-7115.2021.01.010

Asbtract( ) PDF(1444KB) ( )

References| Related Articles| Metrics

Objective: To compare the dynamic changes of procalcitonin (PCT), C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in patients with elective spinal surgery without infection complications, and to compare the three inflammatory markers in early diagnosis of postoperative infection after elective spinal surgery.Methods: Participants were 83 patients (37 women, 46 men) who underwent elective spinal surgery. Clinical variables relevant to the study included age, sex, medical history, surgery duration and type of surgery. Clinical and laboratory data were body temperature (BT), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and PCT, which were measured preoperatively and postoperatively on days 1, 3, and 5. Results: ESR began to rise obviously at the third day after the operation, and still had an upward trend on the fifth day after the operation. The peak of PCT concentration appeared on the first day after operation, which was not related to age, sex, diabetes, hypertension, operation time and the use of instrumentation. The peak value of CRP was found at third days after the operation and increased significantly in the elderly, men, diabetes, hypertension, longer operating time, and the use of instrumentation. Conclusion: Compared with the traditional inflammatory markers of ESR and CRP, PCT has higher sensitivity and specificity as a monitoring indicator of the possibility of infection after spinal surgery, especially in patients with fever. The peak time of PCT is earlier than that of CRP. According to the trend of change, it has higher timeliness for early diagnosis of infection.

Select

Changes of cerebrospinal fluid MIF level in patients with aneurismal subarachnoid hemorrhage and its relationship with delayed cerebral ischemia

WANG Wei

2021, 42(1): 46-48. DOI: 10.3969/j.issn.1004-7115.2021.01.011

Asbtract( ) PDF(1172KB) ( )

References| Related Articles| Metrics

Objective: To investigate the relationship between cerebrospinal fluid(CSF) macrophage migration inhibitory factor (MIF) levels and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: Seventy-one aSAH patients were included and the general clinical data. CSF samples collected from the external ventricular drainage at day 0-3, 4-6 and 7-9 after aSAH were analyzed. The MIF concentration was measured with ELISA kit. Results: Twenty-seven SAH patients developed DCI. The Hunt-Hess grade, WFNS grade, modified Fisher grade, and the MIF concentration in the cerebrospinal fluid increased significantly in aSAH patients with DCI. The MIF concentration within 3 days following hemorrhage significantly correlated with the grade of DCI. Conclusion: CSF level of MIF is correlated with DCI in aSAH patients.

Select

Clinical efficacy observation of local advanced breast cancer with weekly neoadjuvant chemotherapy

GU Ming-qiang

2021, 42(1): 49-52. DOI: 10.3969/j.issn.1004-7115.2021.01.012

Asbtract( ) PDF(1171KB) ( )

References| Related Articles| Metrics

Objective: To evaluate the efficacy and safety of neoadjuvant chemotherapy with paclitaxel administered weekly combined with epirubincin and cyclophosphamide regimen in advanced breast cancer. Methods: From October 1, 2017 to September 30, 2019, 76 patients with advanced breast cancer diagnosed after pathological examination were admitted to the Department of Nail Surgery, Chengwu County People's Hospital, Shandong Province, and paclitaxel was administered intravenously at. 80 mg/m ²(7 d/time), epirubicin 600 mg/m ²(1 d/time) and cyclophosphamide 500 mg/m ²(1 d/time) in the chemotherapy after admission with 21 days as a cycle. Surgery was performed after 3 cycles of neoadjuvant chemotherapy, and radiation therapy was routinely performed in accordance with the NCCN guidelines. According to the solid tumor efficacy evaluation standard (RECIST1.1), the disease progression and adverse reactions of the patients were evaluated according to the WHO standard anti-cancer drug adverse reactions. Results: The completion rate of weekly treatment mode was 86.1%, including 32 patients with complete response (42.1%), 36 patients with progressive disease (47.4%), 7 patients with stable disease (9.2%),one patient with progressive disease(1.3%). During the treatment period, no congestive heart failure occurred in the entire group of patients, and related adverse reactions were observed from 5 aspects including hematological toxicity, nausea and vomiting levels, fatigue, oral inflammation and diarrhea, although most patients had different types of adverse reactions, but all levels of the status were less than those reported in other literatures, and grade Ⅳ nausea and vomiting did not appear. Conclusion: Retrospective analysis of neoadjuvant chemotherapy using epirubicin and cyclophosphamide combined with paclitaxel week treatment is beneficial to the prognosis of patients with advanced breast cancer, and patients tolerate adverse reactions during preoperative chemotherapy.

Select

The value of DCE-MRI combined with DWI in identification of suspected malignant breast lesions

SUN Fang-fang, GENG Jun-zu

2021, 42(1): 53-56. DOI: 10.3969/j.issn.1004-7115.2021.01.013

Asbtract( ) PDF(1200KB) ( )

References| Related Articles| Metrics

Objective: To explore the value of DCE-MRI combined with DWI in identification of suspected malignant breast lesions. Methods: Retrospective analysis was made of 142 pathologically confirmed malignant lesions of 129 patients who underwent breast MR examination in our hospital from January 2017 to October 2018. The clinical data and preoperative MRI data were collected. The lesions were divided into benign and malignant groups according to pathological results. The differences of time to intensity curve (TIC) and apparent diffusion coefficient (ADC) between the two groups were compared. ROC curve was used to analyze the sensitivity, specificity and area under the curve (AUC) of DCE-MRI, DWI and their combination. Results: Among the 142 cases, 89 were malignant and 53 were benign. The sensitivity and specificity of DCE-MRI combined with DWI in the diagnosis of breast cancer were 88.9% and 82.7%, respectively, which were higher than those of DCE-MRI(77.8%,59.6%) and DWI (62.2%, 69.2%) alone, and the AUC was the largest when the two were combined. Conclusion: DCE-MRI has high sensitivity but low specificity. DCE-MRI combined with DWI can not only improve the sensitivity and specificity, but also maximize the accuracy of diagnosis of suspected malignant breast lesions.

Select

Application of chromosome microarray combined with karyotype analysis technology in fetuses with abnormal ultrasound soft index

LIU Jian-sheng

2021, 42(1): 57-60. DOI: 10.3969/j.issn.1004-7115.2021.01.014

Asbtract( ) PDF(1171KB) ( )

References| Related Articles| Metrics

Objective: To find the genetic etiology of fetuses with abnormal ultrasound soft index using chromosome karyotype analysis and chromosome microarray analysis technology and to evaluate its application value.Methods: From January 2018 to April 2020, 90 cases of ultrasound diagnosed fetuses with abnormal soft index were collected in the second trimester of amniotic fluid, chromosome karyotype analysis and chromosome microarray detection were performed, and ultrasonic soft index were analyzed genetically.Results: Ninety cases of abnormal fetal soft index were diagnosed by ultrasound. The detection rate of abnormal ultrasound soft index CNVs was 35.6% (32/90). Among them, benign accounted for 12.5% (4/32), the detection rate of VOUS was 56.2% (18/32), the detection rate of pathogenic CNV was 31.2% (10/32), and 10 cases were induced. There were 73 cases with only abnormal soft indicators and 17 cases with two or more soft indicators. There were 6 cases of pathogenic CNVs detected in two or more abnormal soft index cases, accounting for 35.3% (6/17), which was significantly higher than the detection rate of simple soft index abnormality 5.5%(4/73). The chromosome karyotype analysis showed no abnormalities. CMA detected two abnormal cases, accounting for 20% (2/10) of the pathogenic cases, avoiding the birth of two defective babies. Conclusion: The application of chromosome karyotype analysis combined with CMA detection can improve the genetic detection rate of fetuses with abnormal ultrasound soft index, and further prenatal diagnosis and genetic counseling should be carried out for fetuses with abnormal ultrasound soft index.

Select

Simultaneous determination of eight active components inpolygonum aviculareL. by HPLC

LI Lei

2021, 42(1): 61-65. DOI: 10.3969/j.issn.1004-7115.2021.01.015

Asbtract( ) PDF(1241KB) ( )

References| Related Articles| Metrics

Objective: To develop an HPLC method for simultaneous determination of chlorogenic acid, caffeic acid, myricitrin, hyperoside, galuteolin, quercitrin, quercetin and galangal in polygonum aviculareL.. Methods: The analysis was performed on an Ultimate XB-C ₁₈column (4.6 mm×250 mm, 5 μm) with gradient elution. The mobile phases were 0.5% aqueousphosphoric acid and acetonitrile. The detection wave length was 360 nm. The column temperature was set at 45 ℃. And component content of polygonum aviculareL. in 3 batches from Hebei province was analysed. Results: The eight marker components were separated well with good linearity, precision, stability and repeatability. The recovery rate was 97.62%-111.16%. polygonum aviculareL. in 3 batches from Hebei province had different component contents and proportions. Conclusion: The described method is sensitive, convenient and accurate and is suitable for the simultaneous determination of chlorogenic acid, caffeic acid, myricitrin, hyperoside, galuteolin, quercitrin, quercetin and galangal in polygonum aviculareL.