关键词:阿帕替尼,替吉奥,胃癌,晚期,作用

Abstract:Objective: To investigate the effect of antiangiogenic drug Apatinib combined with fluorouracil drug Sergio (s-1) on the role of chemotherapy in advanced gastric cancer. Methods: Ninety cases of patients with gastric cancer treated in our hospital from January 2017 to December 2018, were randomly divided into three groups, 30 cases in control group for oral Apatinib treatment, 30 cases in control group for oral Sergio treatment, 30 cases observation group for Apatinib and Sergio S-1 treatment,and curative of effect three groups and adverse reactions were compared. Results: The short-term effective rate of 73.33% in the study group was significantly higher than that of the other two groups (43.33% and 40.00%, respectively).By comparing the adverse reactions of the three groups of patients after taking the medicine, liver dysfunction, renal dysfunction and the adverse reactions were significantly reduced was significantly lower than that in the two control groups. The quality of life of the patients in the three groups was compared. In terms of nutrition score, the nutrition score of the study group was significantly higher than that of the control group, and the difference between groups was statistically significant (P<0.05).Conclusion: Apatinib combined with S-1 is more effective and safer than the two single drugs in the treatment of advanced gastric cancer, which is not only conducive to the recovery of patients, but also helpful to the improvement of the quality of life of patients, and can be widely used in clinical practice.

Key words:Apatinib,Tegafur gimeracil oteracil potassium,gastric cancer,function