The mortality rate of colorectal cancer in urban and rural areas of China from 2009 to 2019 was counted， and the standardized mortality rate was calculated. The death trend of colorectal cancer in urban men and women， rural men and women was analyzed by using Joinpoint Regression Software.

Colorectal cancer mortality was higher in urban areas than in rural areas and was higher in men than in women. The overall mortality rate of colorectal cancer among urban residents showed a downward trend （AAPC = -1.26%，P< 0.05）， and the mortality rate of colorectal cancer among urban women also showed a downward trend （AAPC = -2.10%，P< 0.05）. The colorectal cancer mortality rate of rural residents and rural men in China showed a downward trend in 2009－2013 （APC = -6.30%， -7.04%，P< 0.05）， and an upward trend in 2013—2019 （APC = 3.32%， 3.69%，P< 0.05）. The colorectal cancer mortality rate of rural women showed a downward trend in 2009—2012 （APC = -8.25%，P< 0.05）， and an upward trend in 2012—2019 （APC = 2.17%，P< 0.05）. Region， gender， and age were all independent risk factors for colorectal cancer death. The mortality risk of colorectal cancer in urban residents was 1.31 times as that in rural residents （95%CI： 1.02～1.69）. The risk of death from colorectal cancer was 1.57 times higher in men than in women （95%CI： 1.22～2.02）； For each 5-year-old increase， the risk of death from colorectal cancer increased by 1.26 times （95%CI： 1.22～1.31）； The risk of death from colorectal cancer decreased by 1% with year， there was not statistically significant.

The mortality of colorectal cancer among urban residents and urban women in China from 2009 to 2019 shows a declining trend， but rural men and rural women have an increasing trend after 2012. We should continue to strengthen the prevention and treatment of colorectal cancer， pay attention to the prevention in rural areas.